ApInAPDB: a database of apoptosis-inducing anticancer peptides
Abstract ApInAPDB (Apoptosis-Inducing Anticancer Peptides Database) consists of 818 apoptosis-inducing anticancer peptides which are manually collected from research articles. The database provides scholars with peptide related information such as function, binding target and affinity, IC50 and etc....
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25530-6 |
| _version_ | 1811301845206827008 |
|---|---|
| author | Naser Faraji Seyed Shahriar Arab Alireza Doustmohammadi Norelle L. Daly Ahmad Yari Khosroushahi |
| author_facet | Naser Faraji Seyed Shahriar Arab Alireza Doustmohammadi Norelle L. Daly Ahmad Yari Khosroushahi |
| author_sort | Naser Faraji |
| collection | DOAJ |
| description | Abstract ApInAPDB (Apoptosis-Inducing Anticancer Peptides Database) consists of 818 apoptosis-inducing anticancer peptides which are manually collected from research articles. The database provides scholars with peptide related information such as function, binding target and affinity, IC50 and etc. In addition, GRAVY (grand average of hydropathy), net charge at pH 7, hydrophobicity and other physicochemical properties are calculated and presented. Another category of information are structural information includes 3D modeling, secondary structure prediction and descriptors for QSAR (quantitative structure–activity relationship) modeling. In order to facilitate the browsing process, three types of user-friendly searching tools are provided: top categories browser, simple search and advanced search. Overall ApInAPDB as the first database presenting apoptosis-inducing anticancer peptides can be useful in the field of peptide design and especially cancer therapy. Researchers can freely access the database at http://bioinf.modares.ac.ir/software/ApInAPDB/ . |
| first_indexed | 2024-04-13T07:16:12Z |
| format | Article |
| id | doaj.art-ef898608dc83454faa1f184b1df40896 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T07:16:12Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ef898608dc83454faa1f184b1df408962022-12-22T02:56:44ZengNature PortfolioScientific Reports2045-23222022-12-011211710.1038/s41598-022-25530-6ApInAPDB: a database of apoptosis-inducing anticancer peptidesNaser Faraji0Seyed Shahriar Arab1Alireza Doustmohammadi2Norelle L. Daly3Ahmad Yari Khosroushahi4Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesDepartment of Biophysics, Faculty of Biological Sciences, Tarbiat Modares UniversityDepartment of Biophysics, Faculty of Biological Sciences, Tarbiat Modares UniversityCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook UniversityDepartment of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesAbstract ApInAPDB (Apoptosis-Inducing Anticancer Peptides Database) consists of 818 apoptosis-inducing anticancer peptides which are manually collected from research articles. The database provides scholars with peptide related information such as function, binding target and affinity, IC50 and etc. In addition, GRAVY (grand average of hydropathy), net charge at pH 7, hydrophobicity and other physicochemical properties are calculated and presented. Another category of information are structural information includes 3D modeling, secondary structure prediction and descriptors for QSAR (quantitative structure–activity relationship) modeling. In order to facilitate the browsing process, three types of user-friendly searching tools are provided: top categories browser, simple search and advanced search. Overall ApInAPDB as the first database presenting apoptosis-inducing anticancer peptides can be useful in the field of peptide design and especially cancer therapy. Researchers can freely access the database at http://bioinf.modares.ac.ir/software/ApInAPDB/ .https://doi.org/10.1038/s41598-022-25530-6 |
| spellingShingle | Naser Faraji Seyed Shahriar Arab Alireza Doustmohammadi Norelle L. Daly Ahmad Yari Khosroushahi ApInAPDB: a database of apoptosis-inducing anticancer peptides Scientific Reports |
| title | ApInAPDB: a database of apoptosis-inducing anticancer peptides |
| title_full | ApInAPDB: a database of apoptosis-inducing anticancer peptides |
| title_fullStr | ApInAPDB: a database of apoptosis-inducing anticancer peptides |
| title_full_unstemmed | ApInAPDB: a database of apoptosis-inducing anticancer peptides |
| title_short | ApInAPDB: a database of apoptosis-inducing anticancer peptides |
| title_sort | apinapdb a database of apoptosis inducing anticancer peptides |
| url | https://doi.org/10.1038/s41598-022-25530-6 |
| work_keys_str_mv | AT naserfaraji apinapdbadatabaseofapoptosisinducinganticancerpeptides AT seyedshahriararab apinapdbadatabaseofapoptosisinducinganticancerpeptides AT alirezadoustmohammadi apinapdbadatabaseofapoptosisinducinganticancerpeptides AT norelleldaly apinapdbadatabaseofapoptosisinducinganticancerpeptides AT ahmadyarikhosroushahi apinapdbadatabaseofapoptosisinducinganticancerpeptides |