Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission
Abstract. In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The p...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2019-01-01
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| Series: | Transplantation Direct |
| Online Access: | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000852 |
| _version_ | 1818548827543568384 |
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| author | Sarah L. White, PhD William Rawlinson, FRACP, FRCPA, PhD Peter Boan, FRACP, FRCPA Vicky Sheppeard, FAFPHM Germaine Wong, FRACP, PhD Karen Waller, MBBS Helen Opdam, FRACP, FCICM John Kaldor, PhD Michael Fink, MD, FRACS Deborah Verran, MD, FRACS Angela Webster, PhD, FRCP, FRACP Kate Wyburn, FRACP, PhD Lindsay Grayson, MD, FRACP, FAFPHM, FRCP, FIDSA Allan Glanville, MD, FRACP Nick Cross, MD, PhD Ashley Irish, FRACP Toby Coates, FRACP, PhD Anthony Griffin, FRACS Greg Snell, MD, FRACP Stephen I. Alexander, MD, FRACP Scott Campbell, FRACP, PhD Steven Chadban, FRACP, PhD Peter Macdonald, MD, FRACP, PhD Paul Manley, FRACP Eva Mehakovic Vidya Ramachandran, MBBS Alicia Mitchell, PhD Michael Ison, MD |
| author_facet | Sarah L. White, PhD William Rawlinson, FRACP, FRCPA, PhD Peter Boan, FRACP, FRCPA Vicky Sheppeard, FAFPHM Germaine Wong, FRACP, PhD Karen Waller, MBBS Helen Opdam, FRACP, FCICM John Kaldor, PhD Michael Fink, MD, FRACS Deborah Verran, MD, FRACS Angela Webster, PhD, FRCP, FRACP Kate Wyburn, FRACP, PhD Lindsay Grayson, MD, FRACP, FAFPHM, FRCP, FIDSA Allan Glanville, MD, FRACP Nick Cross, MD, PhD Ashley Irish, FRACP Toby Coates, FRACP, PhD Anthony Griffin, FRACS Greg Snell, MD, FRACP Stephen I. Alexander, MD, FRACP Scott Campbell, FRACP, PhD Steven Chadban, FRACP, PhD Peter Macdonald, MD, FRACP, PhD Paul Manley, FRACP Eva Mehakovic Vidya Ramachandran, MBBS Alicia Mitchell, PhD Michael Ison, MD |
| author_sort | Sarah L. White, PhD |
| collection | DOAJ |
| description | Abstract. In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management. Of particular interest at the time of writing was how to maximize utilization of donors at increased risk for transmission of human immunodeficiency virus, hepatitis C virus, and hepatitis B virus, given the recent developments, including the availability of direct-acting antivirals for hepatitis C virus and improvements in donor screening technologies. The review also covers emerging risks associated with recent epidemics (eg, Zika virus) and the risk of transmission of nonendemic pathogens related to donor travel history or country of origin. Lastly, the implications for recipient consent of expanded utilization of donors at increased risk of blood-borne viral disease transmission are considered. |
| first_indexed | 2024-12-12T08:25:27Z |
| format | Article |
| id | doaj.art-ef8c065faade40b78960ef114e635c90 |
| institution | Directory Open Access Journal |
| issn | 2373-8731 |
| language | English |
| last_indexed | 2024-12-12T08:25:27Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Transplantation Direct |
| spelling | doaj.art-ef8c065faade40b78960ef114e635c902022-12-22T00:31:17ZengWolters KluwerTransplantation Direct2373-87312019-01-0151e41610.1097/TXD.0000000000000852201901000-0001Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of TransmissionSarah L. White, PhD0William Rawlinson, FRACP, FRCPA, PhD1Peter Boan, FRACP, FRCPA2Vicky Sheppeard, FAFPHM3Germaine Wong, FRACP, PhD4Karen Waller, MBBS5Helen Opdam, FRACP, FCICM6John Kaldor, PhD7Michael Fink, MD, FRACS8Deborah Verran, MD, FRACS9Angela Webster, PhD, FRCP, FRACP10Kate Wyburn, FRACP, PhD11Lindsay Grayson, MD, FRACP, FAFPHM, FRCP, FIDSA12Allan Glanville, MD, FRACP13Nick Cross, MD, PhD14Ashley Irish, FRACP15Toby Coates, FRACP, PhD16Anthony Griffin, FRACS17Greg Snell, MD, FRACP18Stephen I. Alexander, MD, FRACP19Scott Campbell, FRACP, PhD20Steven Chadban, FRACP, PhD21Peter Macdonald, MD, FRACP, PhD22Paul Manley, FRACP23Eva Mehakovic24Vidya Ramachandran, MBBS25Alicia Mitchell, PhD26Michael Ison, MD271 Central Clinical School, Sydney Medical School, The University of Sydney, Sydney, Australia.2 Serology and Virology Division, NSW Health Pathology Prince of Wales Hospital, Sydney, Australia.4 Departments of Infectious Diseases and Microbiology, Fiona Stanley Hospital, Perth, Australia.6 Communicable Diseases Network Australia, New South Wales Health, Sydney, Australia.7 Centre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia.1 Central Clinical School, Sydney Medical School, The University of Sydney, Sydney, Australia.10 Austin Health, Melbourne, Australia.12 Kirby Institute, University of New South Wales, Sydney, Australia.10 Austin Health, Melbourne, Australia.14 Transplantation Services, Royal Prince Alfred Hospital, Sydney, Australia.7 Centre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia.1 Central Clinical School, Sydney Medical School, The University of Sydney, Sydney, Australia.10 Austin Health, Melbourne, Australia.16 Department of Thoracic Medicine and Lung Transplantation, St Vincent's Hospital, Sydney, Australia.17 Department of Nephrology, Canterbury District Health Board, Christchurch Hospital, Christchurch, New Zealand.18 Department of Nephrology, Fiona Stanley Hospital, Perth, Australia.20 Renal and Transplantation, Royal Adelaide Hospital, Adelaide, Australia.22 Renal Transplantation, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.23 Lung Transplant, Alfred Health, Melbourne, Victoria, Australia.8 Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.24 Department of Renal Medicine, University of Queensland at Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.1 Central Clinical School, Sydney Medical School, The University of Sydney, Sydney, Australia.25 Department of Cardiology, St Vincent's Hospital, Sydney, Australia.27 Kidney Disorders, Auckland District Health Board, Auckland City Hospital, Auckland, New Zealand.11 The Organ and Tissue Authority, Australian Government, Canberra, Australia.2 Serology and Virology Division, NSW Health Pathology Prince of Wales Hospital, Sydney, Australia.16 Department of Thoracic Medicine and Lung Transplantation, St Vincent's Hospital, Sydney, Australia.30 Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL.Abstract. In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management. Of particular interest at the time of writing was how to maximize utilization of donors at increased risk for transmission of human immunodeficiency virus, hepatitis C virus, and hepatitis B virus, given the recent developments, including the availability of direct-acting antivirals for hepatitis C virus and improvements in donor screening technologies. The review also covers emerging risks associated with recent epidemics (eg, Zika virus) and the risk of transmission of nonendemic pathogens related to donor travel history or country of origin. Lastly, the implications for recipient consent of expanded utilization of donors at increased risk of blood-borne viral disease transmission are considered.http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000852 |
| spellingShingle | Sarah L. White, PhD William Rawlinson, FRACP, FRCPA, PhD Peter Boan, FRACP, FRCPA Vicky Sheppeard, FAFPHM Germaine Wong, FRACP, PhD Karen Waller, MBBS Helen Opdam, FRACP, FCICM John Kaldor, PhD Michael Fink, MD, FRACS Deborah Verran, MD, FRACS Angela Webster, PhD, FRCP, FRACP Kate Wyburn, FRACP, PhD Lindsay Grayson, MD, FRACP, FAFPHM, FRCP, FIDSA Allan Glanville, MD, FRACP Nick Cross, MD, PhD Ashley Irish, FRACP Toby Coates, FRACP, PhD Anthony Griffin, FRACS Greg Snell, MD, FRACP Stephen I. Alexander, MD, FRACP Scott Campbell, FRACP, PhD Steven Chadban, FRACP, PhD Peter Macdonald, MD, FRACP, PhD Paul Manley, FRACP Eva Mehakovic Vidya Ramachandran, MBBS Alicia Mitchell, PhD Michael Ison, MD Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission Transplantation Direct |
| title | Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission |
| title_full | Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission |
| title_fullStr | Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission |
| title_full_unstemmed | Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission |
| title_short | Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission |
| title_sort | infectious disease transmission in solid organ transplantation donor evaluation recipient risk and outcomes of transmission |
| url | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000852 |
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