Fabrication of Chitosan-Based Network Polysaccharide Nanogels
In this study, we developed a method to fabricate chitosan-based network polysaccharides via the condensation between amino groups in water-soluble chitosan (WSCS) and a carboxylate-terminated maltooligosaccharide crosslinker. We previously reported on the fabrication of network-polysaccharide-based...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/23/8384 |
| _version_ | 1797462687383289856 |
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| author | Aina Nakamichi Jun-ichi Kadokawa |
| author_facet | Aina Nakamichi Jun-ichi Kadokawa |
| author_sort | Aina Nakamichi |
| collection | DOAJ |
| description | In this study, we developed a method to fabricate chitosan-based network polysaccharides via the condensation between amino groups in water-soluble chitosan (WSCS) and a carboxylate-terminated maltooligosaccharide crosslinker. We previously reported on the fabrication of network-polysaccharide-based macroscopic hydrogels via the chemical crosslinking of water-soluble chitin (WSCh) with the crosslinker. Because the molecular weight of the WSCS was much smaller than that of the WSCh, in the present investigation, the chemical crosslinking of the WSCS with the crosslinker was observed at the nanoscale upon the condensation between amino and carboxylate groups in the presence of a condensing agent, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, and <i>N</i>-hydroxysuccinimide, affording nano-sized chitosan-based network polysaccharides. The occurrence of the crosslinking via the formation of amido linkages was supported by the IR analysis and <sup>1</sup>H NMR measurements after the dissolution via acid hydrolysis in DCl/D<sub>2</sub>O. The products formed nanogels, whose sizes depended on the amino/carboxylate feed ratio. The nanoscale morphology and size of the products were evaluated via scanning electron microscopy, dynamic light scattering analyses, and transition electron microscopy. In the present study, we successfully developed the method to fabricate nanogel materials based on network polysaccharide structures, which can practically be applied as new polysaccharide-based 3D bionanomaterials. |
| first_indexed | 2024-03-09T17:40:11Z |
| format | Article |
| id | doaj.art-ef8c4ef4704a4dab9ba7bdd001e8a6be |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T17:40:11Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ef8c4ef4704a4dab9ba7bdd001e8a6be2023-11-24T11:41:21ZengMDPI AGMolecules1420-30492022-12-012723838410.3390/molecules27238384Fabrication of Chitosan-Based Network Polysaccharide NanogelsAina Nakamichi0Jun-ichi Kadokawa1Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, JapanGraduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, JapanIn this study, we developed a method to fabricate chitosan-based network polysaccharides via the condensation between amino groups in water-soluble chitosan (WSCS) and a carboxylate-terminated maltooligosaccharide crosslinker. We previously reported on the fabrication of network-polysaccharide-based macroscopic hydrogels via the chemical crosslinking of water-soluble chitin (WSCh) with the crosslinker. Because the molecular weight of the WSCS was much smaller than that of the WSCh, in the present investigation, the chemical crosslinking of the WSCS with the crosslinker was observed at the nanoscale upon the condensation between amino and carboxylate groups in the presence of a condensing agent, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, and <i>N</i>-hydroxysuccinimide, affording nano-sized chitosan-based network polysaccharides. The occurrence of the crosslinking via the formation of amido linkages was supported by the IR analysis and <sup>1</sup>H NMR measurements after the dissolution via acid hydrolysis in DCl/D<sub>2</sub>O. The products formed nanogels, whose sizes depended on the amino/carboxylate feed ratio. The nanoscale morphology and size of the products were evaluated via scanning electron microscopy, dynamic light scattering analyses, and transition electron microscopy. In the present study, we successfully developed the method to fabricate nanogel materials based on network polysaccharide structures, which can practically be applied as new polysaccharide-based 3D bionanomaterials.https://www.mdpi.com/1420-3049/27/23/8384chemical crosslinkingfunctional maltooligosaccharidenanogelnetwork polysaccharidewater-soluble chitosan |
| spellingShingle | Aina Nakamichi Jun-ichi Kadokawa Fabrication of Chitosan-Based Network Polysaccharide Nanogels Molecules chemical crosslinking functional maltooligosaccharide nanogel network polysaccharide water-soluble chitosan |
| title | Fabrication of Chitosan-Based Network Polysaccharide Nanogels |
| title_full | Fabrication of Chitosan-Based Network Polysaccharide Nanogels |
| title_fullStr | Fabrication of Chitosan-Based Network Polysaccharide Nanogels |
| title_full_unstemmed | Fabrication of Chitosan-Based Network Polysaccharide Nanogels |
| title_short | Fabrication of Chitosan-Based Network Polysaccharide Nanogels |
| title_sort | fabrication of chitosan based network polysaccharide nanogels |
| topic | chemical crosslinking functional maltooligosaccharide nanogel network polysaccharide water-soluble chitosan |
| url | https://www.mdpi.com/1420-3049/27/23/8384 |
| work_keys_str_mv | AT ainanakamichi fabricationofchitosanbasednetworkpolysaccharidenanogels AT junichikadokawa fabricationofchitosanbasednetworkpolysaccharidenanogels |