Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O‐GlcNAcylation
Abstract O‐GlcNAcylation is a post‐translational modification belonging to the large group of glycosylations. It consists of the modification of cytoplasmic, nuclear, and mitochondrial proteins with a single N‐acetylglucosamine residue by O‐GlcNAc transferase (OGT). Despite its structural simplicity...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-04-01
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| Series: | Natural Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ntls.20220006 |
| _version_ | 1827967001754075136 |
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| author | Céline Schulz Quentin Lemaire Alexandre Berthier Amandine Descat Mostafa Kouach Anne‐Sophie Vercoutter‐Edouart Ikram El Yazidi‐Belkoura Stéphan Hardivillé Jean‐François Goossens Philippe Lefebvre Tony Lefebvre |
| author_facet | Céline Schulz Quentin Lemaire Alexandre Berthier Amandine Descat Mostafa Kouach Anne‐Sophie Vercoutter‐Edouart Ikram El Yazidi‐Belkoura Stéphan Hardivillé Jean‐François Goossens Philippe Lefebvre Tony Lefebvre |
| author_sort | Céline Schulz |
| collection | DOAJ |
| description | Abstract O‐GlcNAcylation is a post‐translational modification belonging to the large group of glycosylations. It consists of the modification of cytoplasmic, nuclear, and mitochondrial proteins with a single N‐acetylglucosamine residue by O‐GlcNAc transferase (OGT). Despite its structural simplicity, O‐GlcNAcylation orchestrates many functions inside the cell. This modification regulates fatty acids synthesis, fat storage, and utilization. The generation of white and brown adipocyte‐OGT knock‐out mice has highlighted the marked interference of O‐GlcNAcylation in adiposity and, as a consequence, in metabolic pathologies. OGT is more especially involved in the regulation of lipolysis, and thermogenesis in brown adipose tissue. In addition, O‐GlcNAcylation directly regulates fatty acid synthase, the main enzyme responsible for fatty acids synthesis, and other lipogenic enzymes and transcription factors. Nevertheless, only a few studies reported connections between O‐GlcNAcylation and homeostasis of cholesterol or its derivatives. This knowledge gap is surprising due to the crucial importance of cholesterol in structuring animal biological membranes and as a precursor of a wide variety of biological compounds. Here, we review the current literature about this topic and discuss future prospects in the field. Key points As a PTM, O‐GlcNAcylation exponentially expands protein functions. O‐GlcNAcylation orchestrates many biological functions in living beings including metabolic fluxes. O‐GlcNAcylation is crucial for fat storage and mobilization, and for fatty acid synthesis but its function in the metabolism of other lipid compounds is less documented. |
| first_indexed | 2024-04-09T17:58:30Z |
| format | Article |
| id | doaj.art-ef8c5d8469834b5285cbfe60fe031f8c |
| institution | Directory Open Access Journal |
| issn | 2698-6248 |
| language | English |
| last_indexed | 2024-04-09T17:58:30Z |
| publishDate | 2023-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Natural Sciences |
| spelling | doaj.art-ef8c5d8469834b5285cbfe60fe031f8c2023-04-14T11:02:09ZengWiley-VCHNatural Sciences2698-62482023-04-0132n/an/a10.1002/ntls.20220006Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O‐GlcNAcylationCéline Schulz0Quentin Lemaire1Alexandre Berthier2Amandine Descat3Mostafa Kouach4Anne‐Sophie Vercoutter‐Edouart5Ikram El Yazidi‐Belkoura6Stéphan Hardivillé7Jean‐François Goossens8Philippe Lefebvre9Tony Lefebvre10CNRS UMR 8576 ‐ UGSF ‐ Unité de Glycobiologie Structurale et Fonctionnelle Université de Lille Lille FranceCNRS UMR 8576 ‐ UGSF ‐ Unité de Glycobiologie Structurale et Fonctionnelle Université de Lille Lille FranceInserm CHU Lille, Institut Pasteur de Lille U1011‐EGID Université de Lille Lille FranceCHU Lille ULR 7365‐GRITA‐Groupe de Recherche sur les Formes Injectables et les Technologies Associées Université de Lille Lille FranceCHU Lille ULR 7365‐GRITA‐Groupe de Recherche sur les Formes Injectables et les Technologies Associées Université de Lille Lille FranceCNRS UMR 8576 ‐ UGSF ‐ Unité de Glycobiologie Structurale et Fonctionnelle Université de Lille Lille FranceCNRS UMR 8576 ‐ UGSF ‐ Unité de Glycobiologie Structurale et Fonctionnelle Université de Lille Lille FranceCNRS UMR 8576 ‐ UGSF ‐ Unité de Glycobiologie Structurale et Fonctionnelle Université de Lille Lille FranceCHU Lille ULR 7365‐GRITA‐Groupe de Recherche sur les Formes Injectables et les Technologies Associées Université de Lille Lille FranceInserm CHU Lille, Institut Pasteur de Lille U1011‐EGID Université de Lille Lille FranceCNRS UMR 8576 ‐ UGSF ‐ Unité de Glycobiologie Structurale et Fonctionnelle Université de Lille Lille FranceAbstract O‐GlcNAcylation is a post‐translational modification belonging to the large group of glycosylations. It consists of the modification of cytoplasmic, nuclear, and mitochondrial proteins with a single N‐acetylglucosamine residue by O‐GlcNAc transferase (OGT). Despite its structural simplicity, O‐GlcNAcylation orchestrates many functions inside the cell. This modification regulates fatty acids synthesis, fat storage, and utilization. The generation of white and brown adipocyte‐OGT knock‐out mice has highlighted the marked interference of O‐GlcNAcylation in adiposity and, as a consequence, in metabolic pathologies. OGT is more especially involved in the regulation of lipolysis, and thermogenesis in brown adipose tissue. In addition, O‐GlcNAcylation directly regulates fatty acid synthase, the main enzyme responsible for fatty acids synthesis, and other lipogenic enzymes and transcription factors. Nevertheless, only a few studies reported connections between O‐GlcNAcylation and homeostasis of cholesterol or its derivatives. This knowledge gap is surprising due to the crucial importance of cholesterol in structuring animal biological membranes and as a precursor of a wide variety of biological compounds. Here, we review the current literature about this topic and discuss future prospects in the field. Key points As a PTM, O‐GlcNAcylation exponentially expands protein functions. O‐GlcNAcylation orchestrates many biological functions in living beings including metabolic fluxes. O‐GlcNAcylation is crucial for fat storage and mobilization, and for fatty acid synthesis but its function in the metabolism of other lipid compounds is less documented.https://doi.org/10.1002/ntls.20220006lipidsmetabolismO‐GlcNAcylation |
| spellingShingle | Céline Schulz Quentin Lemaire Alexandre Berthier Amandine Descat Mostafa Kouach Anne‐Sophie Vercoutter‐Edouart Ikram El Yazidi‐Belkoura Stéphan Hardivillé Jean‐François Goossens Philippe Lefebvre Tony Lefebvre Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O‐GlcNAcylation Natural Sciences lipids metabolism O‐GlcNAcylation |
| title | Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O‐GlcNAcylation |
| title_full | Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O‐GlcNAcylation |
| title_fullStr | Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O‐GlcNAcylation |
| title_full_unstemmed | Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O‐GlcNAcylation |
| title_short | Control of lipid metabolism by the dynamic and nutrient‐dependent post‐translational modification O‐GlcNAcylation |
| title_sort | control of lipid metabolism by the dynamic and nutrient dependent post translational modification o glcnacylation |
| topic | lipids metabolism O‐GlcNAcylation |
| url | https://doi.org/10.1002/ntls.20220006 |
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