Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities
The authors evaluated the isoniazid acetylating phenotype and measured hematocrit, hemoglobin, glucose-6-phosphate dehydrogenase and glutathione reductase activities plus serum sulfadoxin levels in 39 patients with paracoccidioidomycosis (33 males and 6 females) aged 17 to 58 years. Twenty one (53.8...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1991-06-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821991000200008&lng=en&tlng=en |
| _version_ | 1818236793907052544 |
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| author | Benedito Barraviera Paulo Câmara Marques Pereira Jussara Marcondes Machado Maria Julia de Souza Carlos Roberto G. Lima Paulo Roberto Curi Rinaldo Poncio Mendes Domingos Alves Meira |
| author_facet | Benedito Barraviera Paulo Câmara Marques Pereira Jussara Marcondes Machado Maria Julia de Souza Carlos Roberto G. Lima Paulo Roberto Curi Rinaldo Poncio Mendes Domingos Alves Meira |
| author_sort | Benedito Barraviera |
| collection | DOAJ |
| description | The authors evaluated the isoniazid acetylating phenotype and measured hematocrit, hemoglobin, glucose-6-phosphate dehydrogenase and glutathione reductase activities plus serum sulfadoxin levels in 39 patients with paracoccidioidomycosis (33 males and 6 females) aged 17 to 58 years. Twenty one (53.84%) of the patients presented a slow acetylatingphenotype and 18(46.16%) a fast acetylating phenotype. Glucose-6-phosphate- dehydrogenase (G6PD) acti vity was decreased in 5(23.80%) slow acetylators and in 4(22.22%) fast acetylators. Glutathione reductase activity was decreased in 14 (66.66%) slow acetylators and in 12 (66.66%) fast acetylators. Serum levels of free and total sulfadoxin Were higher in slow acetylator (p < 0.02). Analysis of the resultspermitted us to conclude that serum sulfadoxin levels are related to the acetylatorphenotype. Furthermore, sulfadoxin levels were always above 50 µg/ml, a value considered therapeutic. Glutathione reductase deficiency observed in 66% of patients may be related to the intestinal malabsorption of nutrients, among them riboflavin, a FAD precursor vitamin, inpatients with paracoceidioidomycosis. |
| first_indexed | 2024-12-12T12:15:31Z |
| format | Article |
| id | doaj.art-ef8c6bbaa8bc447485956eff5c2ffadd |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T12:15:31Z |
| publishDate | 1991-06-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-ef8c6bbaa8bc447485956eff5c2ffadd2022-12-22T00:24:46ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98491991-06-0124211111410.1590/S0037-86821991000200008S0037-86821991000200008Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activitiesBenedito BarravieraPaulo Câmara Marques PereiraJussara Marcondes MachadoMaria Julia de SouzaCarlos Roberto G. LimaPaulo Roberto CuriRinaldo Poncio MendesDomingos Alves MeiraThe authors evaluated the isoniazid acetylating phenotype and measured hematocrit, hemoglobin, glucose-6-phosphate dehydrogenase and glutathione reductase activities plus serum sulfadoxin levels in 39 patients with paracoccidioidomycosis (33 males and 6 females) aged 17 to 58 years. Twenty one (53.84%) of the patients presented a slow acetylatingphenotype and 18(46.16%) a fast acetylating phenotype. Glucose-6-phosphate- dehydrogenase (G6PD) acti vity was decreased in 5(23.80%) slow acetylators and in 4(22.22%) fast acetylators. Glutathione reductase activity was decreased in 14 (66.66%) slow acetylators and in 12 (66.66%) fast acetylators. Serum levels of free and total sulfadoxin Were higher in slow acetylator (p < 0.02). Analysis of the resultspermitted us to conclude that serum sulfadoxin levels are related to the acetylatorphenotype. Furthermore, sulfadoxin levels were always above 50 µg/ml, a value considered therapeutic. Glutathione reductase deficiency observed in 66% of patients may be related to the intestinal malabsorption of nutrients, among them riboflavin, a FAD precursor vitamin, inpatients with paracoceidioidomycosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821991000200008&lng=en&tlng=enFenótipo acetilador da isoniazidaParacoccidioidomicoseGlicose-6-fosfato desidrogenase (G6PD)Glutationa redutaseSulfadoxina |
| spellingShingle | Benedito Barraviera Paulo Câmara Marques Pereira Jussara Marcondes Machado Maria Julia de Souza Carlos Roberto G. Lima Paulo Roberto Curi Rinaldo Poncio Mendes Domingos Alves Meira Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities Revista da Sociedade Brasileira de Medicina Tropical Fenótipo acetilador da isoniazida Paracoccidioidomicose Glicose-6-fosfato desidrogenase (G6PD) Glutationa redutase Sulfadoxina |
| title | Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities |
| title_full | Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities |
| title_fullStr | Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities |
| title_full_unstemmed | Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities |
| title_short | Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities |
| title_sort | isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels glucose 6 phosphate dehydrogenase and glutathione reductase activities |
| topic | Fenótipo acetilador da isoniazida Paracoccidioidomicose Glicose-6-fosfato desidrogenase (G6PD) Glutationa redutase Sulfadoxina |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821991000200008&lng=en&tlng=en |
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