Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants
Using laser speckle flowgraphy (LSFG), we investigated the time course of changes in choroidal circulation hemodynamics after a cold pressor test in healthy eyes. This prospective study included the right eye of 19 young healthy participants. The macular mean blur rate (MBR) was measured with LSFG....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/9/2/64 |
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| author | Sakurako Imabayashi Yuki Hashimoto Yumi Ishimaru Rino Umemoto Miho Chiyozono Toshitaka Yamanokuchi Takeshi Yoshitomi |
| author_facet | Sakurako Imabayashi Yuki Hashimoto Yumi Ishimaru Rino Umemoto Miho Chiyozono Toshitaka Yamanokuchi Takeshi Yoshitomi |
| author_sort | Sakurako Imabayashi |
| collection | DOAJ |
| description | Using laser speckle flowgraphy (LSFG), we investigated the time course of changes in choroidal circulation hemodynamics after a cold pressor test in healthy eyes. This prospective study included the right eye of 19 young healthy participants. The macular mean blur rate (MBR) was measured with LSFG. The MBR, intraocular pressure (IOP), systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), mean blood pressure (MBP), and ocular perfusion pressure (OPP) were evaluated at baseline; immediately after the test and 10, 20, and 30 min later. Immediately after the test (0 min), SBP, DBP, MBP, and OPP were significantly elevated compared with those at baseline. The macular MBR significantly increased by +10.3 ± 7.1% immediately after the test. However, there was no change after 10, 20, and 30 min in the above parameter. A significant positive correlation of the macular MBR with the SBP, MBP, and OPP was observed. In young healthy individuals, increased sympathetic activity induced by a cold pressor test increases choroidal hemodynamics in the macula along with an increase in systemic circulatory dynamics, which normalizes after 10 min. Therefore, LSFG may provide a novel approach for assessing sympathetic activity and intrinsic vascular responsiveness in the eye. |
| first_indexed | 2024-03-11T04:29:34Z |
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| id | doaj.art-ef8cd1930be945808fe0441edaac5aef |
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| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-03-11T04:29:34Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tomography |
| spelling | doaj.art-ef8cd1930be945808fe0441edaac5aef2023-11-17T21:36:40ZengMDPI AGTomography2379-13812379-139X2023-04-019279079710.3390/tomography9020064Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy ParticipantsSakurako Imabayashi0Yuki Hashimoto1Yumi Ishimaru2Rino Umemoto3Miho Chiyozono4Toshitaka Yamanokuchi5Takeshi Yoshitomi6Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Momochihama 3-6-40, Sawara-ku, Fukuoka 814-0001, JapanDepartment of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Momochihama 3-6-40, Sawara-ku, Fukuoka 814-0001, JapanDepartment of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Momochihama 3-6-40, Sawara-ku, Fukuoka 814-0001, JapanDepartment of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Momochihama 3-6-40, Sawara-ku, Fukuoka 814-0001, JapanDepartment of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Momochihama 3-6-40, Sawara-ku, Fukuoka 814-0001, JapanDepartment of Physical Therapy, Faculty of Medicine, Fukuoka International University of Health and Welfare, Momochihama 3-6-40, Sawara-ku, Fukuoka 814-0001, JapanDepartment of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Momochihama 3-6-40, Sawara-ku, Fukuoka 814-0001, JapanUsing laser speckle flowgraphy (LSFG), we investigated the time course of changes in choroidal circulation hemodynamics after a cold pressor test in healthy eyes. This prospective study included the right eye of 19 young healthy participants. The macular mean blur rate (MBR) was measured with LSFG. The MBR, intraocular pressure (IOP), systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), mean blood pressure (MBP), and ocular perfusion pressure (OPP) were evaluated at baseline; immediately after the test and 10, 20, and 30 min later. Immediately after the test (0 min), SBP, DBP, MBP, and OPP were significantly elevated compared with those at baseline. The macular MBR significantly increased by +10.3 ± 7.1% immediately after the test. However, there was no change after 10, 20, and 30 min in the above parameter. A significant positive correlation of the macular MBR with the SBP, MBP, and OPP was observed. In young healthy individuals, increased sympathetic activity induced by a cold pressor test increases choroidal hemodynamics in the macula along with an increase in systemic circulatory dynamics, which normalizes after 10 min. Therefore, LSFG may provide a novel approach for assessing sympathetic activity and intrinsic vascular responsiveness in the eye.https://www.mdpi.com/2379-139X/9/2/64choroidal circulation hemodynamicslaser speckle flowgraphymean blur rate |
| spellingShingle | Sakurako Imabayashi Yuki Hashimoto Yumi Ishimaru Rino Umemoto Miho Chiyozono Toshitaka Yamanokuchi Takeshi Yoshitomi Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants Tomography choroidal circulation hemodynamics laser speckle flowgraphy mean blur rate |
| title | Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants |
| title_full | Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants |
| title_fullStr | Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants |
| title_full_unstemmed | Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants |
| title_short | Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants |
| title_sort | changes in choroidal circulation hemodynamics measured using laser speckle flowgraphy after a cold pressor test in young healthy participants |
| topic | choroidal circulation hemodynamics laser speckle flowgraphy mean blur rate |
| url | https://www.mdpi.com/2379-139X/9/2/64 |
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