Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery
AIM: To evaluate the effectuality and safety of cataract surgery combined with either ab interno trabeculotomy by the microhook (μLOT) or a single iStent® trabecular bypass implantation (iStent) in eyes with cataract and mild-to-moderate glaucoma. METHODS: This study enrolled subjects with mild-to-m...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2022-07-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2022/7/20220707.pdf |
| _version_ | 1811227680089047040 |
|---|---|
| author | Naoto Tokuda Yasushi Kitaoka Ayaka Tsukamoto Yasuhiro Toyoda Yusuke Yamada Kana Sase Hitoshi Takagi |
| author_facet | Naoto Tokuda Yasushi Kitaoka Ayaka Tsukamoto Yasuhiro Toyoda Yusuke Yamada Kana Sase Hitoshi Takagi |
| author_sort | Naoto Tokuda |
| collection | DOAJ |
| description | AIM: To evaluate the effectuality and safety of cataract surgery combined with either ab interno trabeculotomy by the microhook (μLOT) or a single iStent® trabecular bypass implantation (iStent) in eyes with cataract and mild-to-moderate glaucoma. METHODS: This study enrolled subjects with mild-to-moderate open angle glaucoma with visually significant cataract who used two or more ophthalmic antiglaucoma agents between 60 and 90y of age. Patients underwent cataract surgery cooperated with either implantation of an iStent (iStent-phaco) or excisional goniotomy with the μLOT (μLOT-phaco). Patients underwent μLOT-phaco in the eye with lower the mean deviation, according to the Humphrey field analyzer, while iStent-phaco was carried out on the other eye. Intraocular pressure (IOP) pre- and post-surgery, alterations in anterior chamber flare (ACF), and corneal endothelial cell density (ECD) were estimated. RESULTS: Twenty subjects were enrolled (mean age: 73.6±7.3y). The mean medicated preoperative IOP was 16.7 mm Hg in the μLOT and 16.2 mm Hg in the iStent eyes. The mean final IOP at 12mo was 13.6 mm Hg in the μLOT eyes and 13.6 mm Hg in the iStent eyes, representing a 17.8% and 17.2% reduction, respectively. The preoperative ACF in the μLOT eyes was 9.5 pc/ms and it returned to normal in 30d postoperatively, with a value of 11.4 pc/ms. In the iStent eyes, ACF was 9.6 pc/ms preoperatively and it returned to normal by 7d postoperatively (11.2 pc/ms at day 7), demonstrating that postoperative inflammation was less in the iStent eyes. The corneal ECD in both groups was not significantly decreased. CONCLUSION: In this study, iStent and μLOT are both effective through 12mo of follow-up. Safety is more favorable in the iStent eyes, based on early anterior chamber inflammation. |
| first_indexed | 2024-04-12T09:45:59Z |
| format | Article |
| id | doaj.art-ef8d218e7bed4563ade1473a3f8f7dd6 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-12T09:45:59Z |
| publishDate | 2022-07-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-ef8d218e7bed4563ade1473a3f8f7dd62022-12-22T03:37:57ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982022-07-011571082108810.18240/ijo.2022.07.0720220707Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgeryNaoto Tokuda0Yasushi Kitaoka1Ayaka Tsukamoto2Yasuhiro Toyoda3Yusuke Yamada4Kana Sase5Hitoshi Takagi6Naoto Tokuda. Department of Ophthalmology, St Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku Kawasaki-shi, Kanagawa 216-8851, Japan. tokunao@nifty.comDepartment of Ophthalmology, St Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku Kawasaki-shi, Kanagawa 216-8851, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku Kawasaki-shi, Kanagawa 216-8851, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku Kawasaki-shi, Kanagawa 216-8851, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku Kawasaki-shi, Kanagawa 216-8851, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku Kawasaki-shi, Kanagawa 216-8851, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku Kawasaki-shi, Kanagawa 216-8851, JapanAIM: To evaluate the effectuality and safety of cataract surgery combined with either ab interno trabeculotomy by the microhook (μLOT) or a single iStent® trabecular bypass implantation (iStent) in eyes with cataract and mild-to-moderate glaucoma. METHODS: This study enrolled subjects with mild-to-moderate open angle glaucoma with visually significant cataract who used two or more ophthalmic antiglaucoma agents between 60 and 90y of age. Patients underwent cataract surgery cooperated with either implantation of an iStent (iStent-phaco) or excisional goniotomy with the μLOT (μLOT-phaco). Patients underwent μLOT-phaco in the eye with lower the mean deviation, according to the Humphrey field analyzer, while iStent-phaco was carried out on the other eye. Intraocular pressure (IOP) pre- and post-surgery, alterations in anterior chamber flare (ACF), and corneal endothelial cell density (ECD) were estimated. RESULTS: Twenty subjects were enrolled (mean age: 73.6±7.3y). The mean medicated preoperative IOP was 16.7 mm Hg in the μLOT and 16.2 mm Hg in the iStent eyes. The mean final IOP at 12mo was 13.6 mm Hg in the μLOT eyes and 13.6 mm Hg in the iStent eyes, representing a 17.8% and 17.2% reduction, respectively. The preoperative ACF in the μLOT eyes was 9.5 pc/ms and it returned to normal in 30d postoperatively, with a value of 11.4 pc/ms. In the iStent eyes, ACF was 9.6 pc/ms preoperatively and it returned to normal by 7d postoperatively (11.2 pc/ms at day 7), demonstrating that postoperative inflammation was less in the iStent eyes. The corneal ECD in both groups was not significantly decreased. CONCLUSION: In this study, iStent and μLOT are both effective through 12mo of follow-up. Safety is more favorable in the iStent eyes, based on early anterior chamber inflammation.http://ies.ijo.cn/en_publish/2022/7/20220707.pdfminimally invasive glaucoma surgeryistentab interno trabeculotomy |
| spellingShingle | Naoto Tokuda Yasushi Kitaoka Ayaka Tsukamoto Yasuhiro Toyoda Yusuke Yamada Kana Sase Hitoshi Takagi Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery International Journal of Ophthalmology minimally invasive glaucoma surgery istent ab interno trabeculotomy |
| title | Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery |
| title_full | Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery |
| title_fullStr | Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery |
| title_full_unstemmed | Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery |
| title_short | Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery |
| title_sort | comparison of minimally invasive glaucoma surgery with trabecular micro bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery |
| topic | minimally invasive glaucoma surgery istent ab interno trabeculotomy |
| url | http://ies.ijo.cn/en_publish/2022/7/20220707.pdf |
| work_keys_str_mv | AT naototokuda comparisonofminimallyinvasiveglaucomasurgerywithtrabecularmicrobypassstentandmicrohookabinternotrabeculotomyperformedinconjunctionwithcataractsurgery AT yasushikitaoka comparisonofminimallyinvasiveglaucomasurgerywithtrabecularmicrobypassstentandmicrohookabinternotrabeculotomyperformedinconjunctionwithcataractsurgery AT ayakatsukamoto comparisonofminimallyinvasiveglaucomasurgerywithtrabecularmicrobypassstentandmicrohookabinternotrabeculotomyperformedinconjunctionwithcataractsurgery AT yasuhirotoyoda comparisonofminimallyinvasiveglaucomasurgerywithtrabecularmicrobypassstentandmicrohookabinternotrabeculotomyperformedinconjunctionwithcataractsurgery AT yusukeyamada comparisonofminimallyinvasiveglaucomasurgerywithtrabecularmicrobypassstentandmicrohookabinternotrabeculotomyperformedinconjunctionwithcataractsurgery AT kanasase comparisonofminimallyinvasiveglaucomasurgerywithtrabecularmicrobypassstentandmicrohookabinternotrabeculotomyperformedinconjunctionwithcataractsurgery AT hitoshitakagi comparisonofminimallyinvasiveglaucomasurgerywithtrabecularmicrobypassstentandmicrohookabinternotrabeculotomyperformedinconjunctionwithcataractsurgery |