A Novel Therapeutic Approach of 980 nm Photobiomodulation Delivered with Flattop Beam Profile in Management of Recurrent Aphthous Stomatitis in Paediatrics and Adolescents—A Case Series with 3-Month Follow-Up
<b>Background/Objectives</b>: Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal lesions and a very debilitating lesion, especially in paediatric and adolescent patients. The current pharmacotherapy offers a pain relief but not without side effects, and therefore...
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MDPI AG
2024-03-01
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| Online Access: | https://www.mdpi.com/2077-0383/13/7/2007 |
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| author | Reem Hanna Ioana Cristina Miron Stefano Benedicenti |
| author_facet | Reem Hanna Ioana Cristina Miron Stefano Benedicenti |
| author_sort | Reem Hanna |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal lesions and a very debilitating lesion, especially in paediatric and adolescent patients. The current pharmacotherapy offers a pain relief but not without side effects, and therefore photobiomodulation (PBM) can be an alternative therapy. To the authors’ best knowledge, no published study has explored the efficacy of λ 980 nm laser PBM in the management of all RAS subtypes in paediatric and adolescent patients, and therefore, this prospective observational clinical study was conducted to bridge this gap by evaluating λ 980 nm laser PBM efficacy in symptomatic RAS management in paediatric and adolescent patients. The objectives were to evaluate (1) pain intensity alleviation; (2) wound healing rate; (3) wound size closure; (4) a complete resolution; (5) evidence of recurrence; and (6) patients’ treatment satisfaction. <b>Methods</b>: The study’s variables were assessed at the following timepoints: T0: pre-treatment; T1: immediately after first PBM session; T2: 5 hours (h) post first PBM session (via telephone call); T3: immediately after second PBM session (three days post first PBM session); T4: three-day follow-up (after complete PBM treatments); T5: two-week follow-up; and T6: three-month follow-up. The following PBM dosimetry and treatment protocols were employed: λ 980 nm; 300 mW; 60 s; 18 J; CW; flattop beam profile of 1 cm<sup>2</sup> spot size; 18 J/cm<sup>2</sup>; and twice-a-week irradiation (72 h interval). <b>Results</b>: At T1, significant immediate pain intensity relief was reported. 33.33% recorded “4” and 66.67% reported “5” on the quantitative numeric pain intensity scale (NPIS), and this continued to improve significantly (83.33%) at T2. All the subjects reported “0” on the NPIS at T3, T4, T5 and T6. There was a significant reduction in the lesion surface area (>50% complete healing) at T3 compared to T0. Complete healing (100%) with no evidence of scarring and lesion recurrence observed at T4, T5 and T6. Very good patients’ satisfaction was reported at all timepoints. <b>Conclusions</b>: This is the first report demonstrating λ980 nm efficacy in all RAS subtype management in paediatric and adolescent patients with a 3-month follow-up, whereby its PBM dosimetry and treatment protocols were effective from scientific and practical standpoints, and hence multicentre RCTs with large data are warranted to validate its reproducibility and to enrich the knowledge of PBM application in all RAS subtypes. |
| first_indexed | 2024-04-24T10:41:46Z |
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| spelling | doaj.art-ef8e8910a6e24dc9bd00d3d30639f3c82024-04-12T13:21:17ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01137200710.3390/jcm13072007A Novel Therapeutic Approach of 980 nm Photobiomodulation Delivered with Flattop Beam Profile in Management of Recurrent Aphthous Stomatitis in Paediatrics and Adolescents—A Case Series with 3-Month Follow-UpReem Hanna0Ioana Cristina Miron1Stefano Benedicenti2Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132 Genoa, ItalyDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132 Genoa, ItalyDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132 Genoa, Italy<b>Background/Objectives</b>: Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal lesions and a very debilitating lesion, especially in paediatric and adolescent patients. The current pharmacotherapy offers a pain relief but not without side effects, and therefore photobiomodulation (PBM) can be an alternative therapy. To the authors’ best knowledge, no published study has explored the efficacy of λ 980 nm laser PBM in the management of all RAS subtypes in paediatric and adolescent patients, and therefore, this prospective observational clinical study was conducted to bridge this gap by evaluating λ 980 nm laser PBM efficacy in symptomatic RAS management in paediatric and adolescent patients. The objectives were to evaluate (1) pain intensity alleviation; (2) wound healing rate; (3) wound size closure; (4) a complete resolution; (5) evidence of recurrence; and (6) patients’ treatment satisfaction. <b>Methods</b>: The study’s variables were assessed at the following timepoints: T0: pre-treatment; T1: immediately after first PBM session; T2: 5 hours (h) post first PBM session (via telephone call); T3: immediately after second PBM session (three days post first PBM session); T4: three-day follow-up (after complete PBM treatments); T5: two-week follow-up; and T6: three-month follow-up. The following PBM dosimetry and treatment protocols were employed: λ 980 nm; 300 mW; 60 s; 18 J; CW; flattop beam profile of 1 cm<sup>2</sup> spot size; 18 J/cm<sup>2</sup>; and twice-a-week irradiation (72 h interval). <b>Results</b>: At T1, significant immediate pain intensity relief was reported. 33.33% recorded “4” and 66.67% reported “5” on the quantitative numeric pain intensity scale (NPIS), and this continued to improve significantly (83.33%) at T2. All the subjects reported “0” on the NPIS at T3, T4, T5 and T6. There was a significant reduction in the lesion surface area (>50% complete healing) at T3 compared to T0. Complete healing (100%) with no evidence of scarring and lesion recurrence observed at T4, T5 and T6. Very good patients’ satisfaction was reported at all timepoints. <b>Conclusions</b>: This is the first report demonstrating λ980 nm efficacy in all RAS subtype management in paediatric and adolescent patients with a 3-month follow-up, whereby its PBM dosimetry and treatment protocols were effective from scientific and practical standpoints, and hence multicentre RCTs with large data are warranted to validate its reproducibility and to enrich the knowledge of PBM application in all RAS subtypes.https://www.mdpi.com/2077-0383/13/7/2007980 nmdiode laserfree radicalslesion resolutionLLLToxidative stress |
| spellingShingle | Reem Hanna Ioana Cristina Miron Stefano Benedicenti A Novel Therapeutic Approach of 980 nm Photobiomodulation Delivered with Flattop Beam Profile in Management of Recurrent Aphthous Stomatitis in Paediatrics and Adolescents—A Case Series with 3-Month Follow-Up Journal of Clinical Medicine 980 nm diode laser free radicals lesion resolution LLLT oxidative stress |
| title | A Novel Therapeutic Approach of 980 nm Photobiomodulation Delivered with Flattop Beam Profile in Management of Recurrent Aphthous Stomatitis in Paediatrics and Adolescents—A Case Series with 3-Month Follow-Up |
| title_full | A Novel Therapeutic Approach of 980 nm Photobiomodulation Delivered with Flattop Beam Profile in Management of Recurrent Aphthous Stomatitis in Paediatrics and Adolescents—A Case Series with 3-Month Follow-Up |
| title_fullStr | A Novel Therapeutic Approach of 980 nm Photobiomodulation Delivered with Flattop Beam Profile in Management of Recurrent Aphthous Stomatitis in Paediatrics and Adolescents—A Case Series with 3-Month Follow-Up |
| title_full_unstemmed | A Novel Therapeutic Approach of 980 nm Photobiomodulation Delivered with Flattop Beam Profile in Management of Recurrent Aphthous Stomatitis in Paediatrics and Adolescents—A Case Series with 3-Month Follow-Up |
| title_short | A Novel Therapeutic Approach of 980 nm Photobiomodulation Delivered with Flattop Beam Profile in Management of Recurrent Aphthous Stomatitis in Paediatrics and Adolescents—A Case Series with 3-Month Follow-Up |
| title_sort | novel therapeutic approach of 980 nm photobiomodulation delivered with flattop beam profile in management of recurrent aphthous stomatitis in paediatrics and adolescents a case series with 3 month follow up |
| topic | 980 nm diode laser free radicals lesion resolution LLLT oxidative stress |
| url | https://www.mdpi.com/2077-0383/13/7/2007 |
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