Levetirazetam: antiepileptic-induced psychosis
Introduction Levetirazetam is an antiepileptic drug with psychiatric adverse reactions. It includes psychosis, paranoia or hallucinations. The frequency is less than 1%. Objectives To describe a case of Psychosis produced by Levetirazetam Methods Retrospective review of clinical records and compl...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822018909/type/journal_article |
| _version_ | 1827754347502501888 |
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| author | C. Vilella Martín P. García Vázquez Y. Barrera García P. Fernández Perea A. Serrano García M.Á. Alonso De La Torre López R. Gómez Martínez C. Franch Pato |
| author_facet | C. Vilella Martín P. García Vázquez Y. Barrera García P. Fernández Perea A. Serrano García M.Á. Alonso De La Torre López R. Gómez Martínez C. Franch Pato |
| author_sort | C. Vilella Martín |
| collection | DOAJ |
| description |
Introduction
Levetirazetam is an antiepileptic drug with psychiatric adverse reactions. It includes psychosis, paranoia or hallucinations. The frequency is less than 1%.
Objectives
To describe a case of Psychosis produced by Levetirazetam
Methods
Retrospective review of clinical records and complementary test, including psychiatry, electrophysiology and neurology. Diagnosis schales such as Salamanca Questionnaire were used as suport.
Results
A 42-year-old woman diagnosed with tuberous sclerosis and undergoing treatment with levetirazetam acudes to the emergency department for behavioral disorders. She has presented an episode of aggression against a relative threatening him with a kitchen knife. The family reports that since the change in antiepilepticus 1 month ago, the patient has presented strange behaviors. Te Patient is conscious, uncooperative. Barely Approachable. Suspicious of her surroundings, with psychomotor restlessness, self-reference ideas and sparse speech. Auditory hallucinations seem to be present, as well as depressed and irritable mood. Psychic and somatic anxiety is found.
Levetirazetam is discontinued, being replaced by valproic acid. Risperidone is started at a 3 mg dose. Treatment is well tolerated, and clinical stability is achived. Cluster A personality traits are found. Complementary test Blood and Urine simples, Imaging tests (CT and MRI), electroencephalogram and Electrocardiogram show no alterations
Conclusions
Levetirazetam can cause psychiatric adverse effects. it is important to make a proper diagnosis before a first psychotic outbreak in later life. Drugs that can produce psychiatric side effects should be identified and patients should be inform.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:47:45Z |
| format | Article |
| id | doaj.art-ef901a2b59d34e07bfc5c46ac81e6b41 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:47:45Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-ef901a2b59d34e07bfc5c46ac81e6b412023-11-17T05:07:19ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S732S73210.1192/j.eurpsy.2022.1890Levetirazetam: antiepileptic-induced psychosisC. Vilella Martín0P. García Vázquez1Y. Barrera García2P. Fernández Perea3A. Serrano García4M.Á. Alonso De La Torre López5R. Gómez Martínez6C. Franch Pato7Complejo Asistencial Universitario de León, Psychiatry, LEÓN, SpainComplejo Asistencial Universitario de León, Psychiatry, LEÓN, SpainComplejo Asistencial Universitario de León, Psychiatry, LEÓN, SpainComplejo Asistencial Universitario de León, Psychiatry, LEÓN, SpainComplejo Asistencial Universitario de León, Psychiatry, LEÓN, SpainComplejo Asistencial Universitario de León, Psychiatry, LEÓN, SpainComplejo Asistencial Universitario de León, Psychiatry, LEÓN, SpainComplejo Asistencial Universitario de León, Psychiatry, LEÓN, Spain Introduction Levetirazetam is an antiepileptic drug with psychiatric adverse reactions. It includes psychosis, paranoia or hallucinations. The frequency is less than 1%. Objectives To describe a case of Psychosis produced by Levetirazetam Methods Retrospective review of clinical records and complementary test, including psychiatry, electrophysiology and neurology. Diagnosis schales such as Salamanca Questionnaire were used as suport. Results A 42-year-old woman diagnosed with tuberous sclerosis and undergoing treatment with levetirazetam acudes to the emergency department for behavioral disorders. She has presented an episode of aggression against a relative threatening him with a kitchen knife. The family reports that since the change in antiepilepticus 1 month ago, the patient has presented strange behaviors. Te Patient is conscious, uncooperative. Barely Approachable. Suspicious of her surroundings, with psychomotor restlessness, self-reference ideas and sparse speech. Auditory hallucinations seem to be present, as well as depressed and irritable mood. Psychic and somatic anxiety is found. Levetirazetam is discontinued, being replaced by valproic acid. Risperidone is started at a 3 mg dose. Treatment is well tolerated, and clinical stability is achived. Cluster A personality traits are found. Complementary test Blood and Urine simples, Imaging tests (CT and MRI), electroencephalogram and Electrocardiogram show no alterations Conclusions Levetirazetam can cause psychiatric adverse effects. it is important to make a proper diagnosis before a first psychotic outbreak in later life. Drugs that can produce psychiatric side effects should be identified and patients should be inform. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822018909/type/journal_articlePsychosislevetirazetamantiepileptic |
| spellingShingle | C. Vilella Martín P. García Vázquez Y. Barrera García P. Fernández Perea A. Serrano García M.Á. Alonso De La Torre López R. Gómez Martínez C. Franch Pato Levetirazetam: antiepileptic-induced psychosis European Psychiatry Psychosis levetirazetam antiepileptic |
| title | Levetirazetam: antiepileptic-induced psychosis |
| title_full | Levetirazetam: antiepileptic-induced psychosis |
| title_fullStr | Levetirazetam: antiepileptic-induced psychosis |
| title_full_unstemmed | Levetirazetam: antiepileptic-induced psychosis |
| title_short | Levetirazetam: antiepileptic-induced psychosis |
| title_sort | levetirazetam antiepileptic induced psychosis |
| topic | Psychosis levetirazetam antiepileptic |
| url | https://www.cambridge.org/core/product/identifier/S0924933822018909/type/journal_article |
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