Next Generation Fecal Microbiota Transplantation
Fecal microbiota transplantation (FMT) is considered as an effective treatment for Clostridioides difficile infection. However, the precise mechanism of FMT is yet to be determined. Human stool consists of the gut microbiota, bacterial debris, and metabolic products. Of these, the intestinal microbi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Gastrointestinal Endoscopy
2021-03-01
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| Series: | Clinical Endoscopy |
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| Online Access: | http://www.e-ce.org/upload/pdf/ce-2021-053.pdf |
| _version_ | 1797428426107256832 |
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| author | Tae-Geun Gweon Soo-Young Na |
| author_facet | Tae-Geun Gweon Soo-Young Na |
| author_sort | Tae-Geun Gweon |
| collection | DOAJ |
| description | Fecal microbiota transplantation (FMT) is considered as an effective treatment for Clostridioides difficile infection. However, the precise mechanism of FMT is yet to be determined. Human stool consists of the gut microbiota, bacterial debris, and metabolic products. Of these, the intestinal microbiota is the most important factor that exerts therapeutic efficacy in FMT. Fresh donor stool, blended with normal saline, has been employed for traditional FMT. Nevertheless, stool processing is a major impediment in FMT. Frozen stool and capsule formulations have similar efficacy to that of fresh stool. In addition, several novel stool products have been identified. A stool bank that provides stool products with pre-screened donor stool has been established to help physicians and thereby facilitate FMT. Recent next-generation sequencing techniques have been key in facilitating the detailed analysis of the microbiota and gut environment of individual donors and recipients. |
| first_indexed | 2024-03-09T08:57:40Z |
| format | Article |
| id | doaj.art-ef90600f80b7465fa56d9f524342fccc |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-09T08:57:40Z |
| publishDate | 2021-03-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-ef90600f80b7465fa56d9f524342fccc2023-12-02T12:45:10ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432021-03-0154215215610.5946/ce.2021.0537504Next Generation Fecal Microbiota TransplantationTae-Geun Gweon0Soo-Young Na1 Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaFecal microbiota transplantation (FMT) is considered as an effective treatment for Clostridioides difficile infection. However, the precise mechanism of FMT is yet to be determined. Human stool consists of the gut microbiota, bacterial debris, and metabolic products. Of these, the intestinal microbiota is the most important factor that exerts therapeutic efficacy in FMT. Fresh donor stool, blended with normal saline, has been employed for traditional FMT. Nevertheless, stool processing is a major impediment in FMT. Frozen stool and capsule formulations have similar efficacy to that of fresh stool. In addition, several novel stool products have been identified. A stool bank that provides stool products with pre-screened donor stool has been established to help physicians and thereby facilitate FMT. Recent next-generation sequencing techniques have been key in facilitating the detailed analysis of the microbiota and gut environment of individual donors and recipients.http://www.e-ce.org/upload/pdf/ce-2021-053.pdfclostridioides difficile infectionfecal microbiota transplantationmicrobiota |
| spellingShingle | Tae-Geun Gweon Soo-Young Na Next Generation Fecal Microbiota Transplantation Clinical Endoscopy clostridioides difficile infection fecal microbiota transplantation microbiota |
| title | Next Generation Fecal Microbiota Transplantation |
| title_full | Next Generation Fecal Microbiota Transplantation |
| title_fullStr | Next Generation Fecal Microbiota Transplantation |
| title_full_unstemmed | Next Generation Fecal Microbiota Transplantation |
| title_short | Next Generation Fecal Microbiota Transplantation |
| title_sort | next generation fecal microbiota transplantation |
| topic | clostridioides difficile infection fecal microbiota transplantation microbiota |
| url | http://www.e-ce.org/upload/pdf/ce-2021-053.pdf |
| work_keys_str_mv | AT taegeungweon nextgenerationfecalmicrobiotatransplantation AT sooyoungna nextgenerationfecalmicrobiotatransplantation |