AGTR1rs5186 Polymorphism Is Associated with the Risk of Restenosis after Percutaneous Coronary Intervention: A Meta-Analysis
Background: Progress has been made in genetic investigations on restenosis for the past 20 years, many studies regarding <i>AGTR1</i> rs5186 polymorphism and restenosis after percutaneous coronary intervention (PCI) have been published, but the result remains controversial. The study aim...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/9/11/406 |
| _version_ | 1797465000638414848 |
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| author | Feng Lv Yufeng Jiang Yebao Wang Ting Zhang Yafeng Zhou |
| author_facet | Feng Lv Yufeng Jiang Yebao Wang Ting Zhang Yafeng Zhou |
| author_sort | Feng Lv |
| collection | DOAJ |
| description | Background: Progress has been made in genetic investigations on restenosis for the past 20 years, many studies regarding <i>AGTR1</i> rs5186 polymorphism and restenosis after percutaneous coronary intervention (PCI) have been published, but the result remains controversial. The study aimed to explore the relationship between rs5186 polymorphism and the risk of restenosis after PCI. Methods: We performed a systematic search on PubMed, Web of Science, Embase, CNKI, and Wan Fang databases up to December 2021. Two authors individually extracted all useful data of each study involved in this meta-analysis and assessed the study quality using the Newcastle-Ottawa scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined in different genetic models for evaluation using a random-effects model or fixed-effect model. Results: There were eventually 8 studies of 1111 cases and 4097 controls eligible for this meta-analysis. Significant associations were found between rs5186 polymorphism and restenosis after PCI.allelic (OR: 1.31, 95% CI: 1.17–1.47, <i>p</i> < 0.001), homozygous (OR: 1.90, 95% CI: 1.50–2.44, <i>p</i> < 0.001), heterozygous (OR: 1.10, 95% CI: 0.93–1.29, <i>p</i> = 0.27), recessive (OR: 1.80, 95% CI: 1.37–2.36, <i>p</i> < 0.001), dominant genetic model (OR: 1.24, 95% CI: 1.06–1.44, <i>p</i> = 0.006). Subgroup analyses indicated a significant association in Asians. Conclusions: The rs5186 polymorphism in the <i>AGTR1</i> gene increases the risk of restenosis after PCI in Asians significantly. |
| first_indexed | 2024-03-09T18:15:14Z |
| format | Article |
| id | doaj.art-ef90f37de30542519ef71d93897bddfc |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-09T18:15:14Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-ef90f37de30542519ef71d93897bddfc2023-11-24T08:46:59ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252022-11-0191140610.3390/jcdd9110406AGTR1rs5186 Polymorphism Is Associated with the Risk of Restenosis after Percutaneous Coronary Intervention: A Meta-AnalysisFeng Lv0Yufeng Jiang1Yebao Wang2Ting Zhang3Yafeng Zhou4Department of Cardiology, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou 215125, ChinaDepartment of Cardiology, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou 215125, ChinaDepartment of Cardiology, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou 215125, ChinaDepartment of Cardiology, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou 215125, ChinaDepartment of Cardiology, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou 215125, ChinaBackground: Progress has been made in genetic investigations on restenosis for the past 20 years, many studies regarding <i>AGTR1</i> rs5186 polymorphism and restenosis after percutaneous coronary intervention (PCI) have been published, but the result remains controversial. The study aimed to explore the relationship between rs5186 polymorphism and the risk of restenosis after PCI. Methods: We performed a systematic search on PubMed, Web of Science, Embase, CNKI, and Wan Fang databases up to December 2021. Two authors individually extracted all useful data of each study involved in this meta-analysis and assessed the study quality using the Newcastle-Ottawa scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined in different genetic models for evaluation using a random-effects model or fixed-effect model. Results: There were eventually 8 studies of 1111 cases and 4097 controls eligible for this meta-analysis. Significant associations were found between rs5186 polymorphism and restenosis after PCI.allelic (OR: 1.31, 95% CI: 1.17–1.47, <i>p</i> < 0.001), homozygous (OR: 1.90, 95% CI: 1.50–2.44, <i>p</i> < 0.001), heterozygous (OR: 1.10, 95% CI: 0.93–1.29, <i>p</i> = 0.27), recessive (OR: 1.80, 95% CI: 1.37–2.36, <i>p</i> < 0.001), dominant genetic model (OR: 1.24, 95% CI: 1.06–1.44, <i>p</i> = 0.006). Subgroup analyses indicated a significant association in Asians. Conclusions: The rs5186 polymorphism in the <i>AGTR1</i> gene increases the risk of restenosis after PCI in Asians significantly.https://www.mdpi.com/2308-3425/9/11/406cardiovascular diseasers5186percutaneous coronary interventionpolymorphism |
| spellingShingle | Feng Lv Yufeng Jiang Yebao Wang Ting Zhang Yafeng Zhou AGTR1rs5186 Polymorphism Is Associated with the Risk of Restenosis after Percutaneous Coronary Intervention: A Meta-Analysis Journal of Cardiovascular Development and Disease cardiovascular disease rs5186 percutaneous coronary intervention polymorphism |
| title | AGTR1rs5186 Polymorphism Is Associated with the Risk of Restenosis after Percutaneous Coronary Intervention: A Meta-Analysis |
| title_full | AGTR1rs5186 Polymorphism Is Associated with the Risk of Restenosis after Percutaneous Coronary Intervention: A Meta-Analysis |
| title_fullStr | AGTR1rs5186 Polymorphism Is Associated with the Risk of Restenosis after Percutaneous Coronary Intervention: A Meta-Analysis |
| title_full_unstemmed | AGTR1rs5186 Polymorphism Is Associated with the Risk of Restenosis after Percutaneous Coronary Intervention: A Meta-Analysis |
| title_short | AGTR1rs5186 Polymorphism Is Associated with the Risk of Restenosis after Percutaneous Coronary Intervention: A Meta-Analysis |
| title_sort | agtr1rs5186 polymorphism is associated with the risk of restenosis after percutaneous coronary intervention a meta analysis |
| topic | cardiovascular disease rs5186 percutaneous coronary intervention polymorphism |
| url | https://www.mdpi.com/2308-3425/9/11/406 |
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