The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis
Introduction Depression and anxiety share similar symptoms with rheumatoid arthritis (RA) and these conditions are often not diagnosed or overlooked in RA. This study aimed to determine the prevalence of depression/anxiety in RA and their correlation with RA activity. Material and methods Rheumatoi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-02-01
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| Series: | Rheumatology |
| Subjects: | |
| Online Access: | https://reu.termedia.pl/The-prevalence-and-correlation-of-depression-and-anxiety-with-disease-activity-in,154905,0,2.html |
| _version_ | 1797435149503168512 |
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| author | Sousan Moudi Behzad Heidari Behnaz Yousefghahari Reza Gholami Hemmat Gholinia Mansour Babaei |
| author_facet | Sousan Moudi Behzad Heidari Behnaz Yousefghahari Reza Gholami Hemmat Gholinia Mansour Babaei |
| author_sort | Sousan Moudi |
| collection | DOAJ |
| description | Introduction
Depression and anxiety share similar symptoms with rheumatoid arthritis (RA) and these conditions are often not diagnosed or overlooked in RA. This study aimed to determine the prevalence of depression/anxiety in RA and their correlation with RA activity.
Material and methods
Rheumatoid arthritis patients who presented at a rheumatology clinic were selected consecutively. The diagnosis of RA was confirmed by the ACR/EULAR criteria, disease activity was assessed by Dis-ease Activity Score based on the 28-joint count (DAS28) and patients with DAS28 > 2.6 were consid-ered to have active RA. The diagnosis of depression and anxiety was made by the Hospital Anxiety and Depression Scale (HADS). The Pearson test was used to determine the correlation between DAS28 and HADS scores.
Results
Two-hundred patients (female, 82%) with a mean age of 53.5 ±10.1 years and mean disease dura-tion of 6.6 ±6.8 years were studied. Depression was diagnosed in 27 (13.5%) patients and anxiety in 38 (19%) patients. The DAS28 score correlated positively with depression ( r = 0.173, p = 0.014) and anxiety score ( r = 0.229, p = 0.001). In multiple logistic regression analysis after adjustment for all covariates, age < 40 years and female sex were independently associated with RA activity in patients with depression, with OR = 4.21 ( p = 0.002) and OR = 3.56 ( p = 0.028) respectively.
Conclusions
These findings indicate that depression and anxiety are prevalent in RA and correlate positively with active disease in particular in depressive female patients aged < 40 years. |
| first_indexed | 2024-03-09T10:44:03Z |
| format | Article |
| id | doaj.art-ef92432b86ef418098dfa767a5fc95c5 |
| institution | Directory Open Access Journal |
| issn | 0034-6233 2084-9834 |
| language | English |
| last_indexed | 2024-03-09T10:44:03Z |
| publishDate | 2023-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj.art-ef92432b86ef418098dfa767a5fc95c52023-12-01T12:11:15ZengTermedia Publishing HouseRheumatology0034-62332084-98342023-02-01612869110.5114/reum/154905154905The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritisSousan Moudi0https://orcid.org/0000-0002-6573-8861Behzad Heidari1Behnaz Yousefghahari2https://orcid.org/0000-0002-8416-6643Reza Gholami3Hemmat Gholinia4Mansour Babaei5Health Research Center, Master of Biostatist and Epidemiology, Babol University of Medical Science, Babol, Iran.Clinical research development unit of Rouhani, Babol University of Medical Sciences, Babol, IranClinical research development unit of Rouhani, Babol University of Medical Sciences, Babol, IranStudent research ccommittee, Babol University of Medical Sciences, Babol, Iran.Clinical research development unit of Rouhani, Babol University of Medical Sciences, Babol, IranClinical research development unit of Rouhani Hospital,Babol University of Medical Sciences, Babol.Introduction Depression and anxiety share similar symptoms with rheumatoid arthritis (RA) and these conditions are often not diagnosed or overlooked in RA. This study aimed to determine the prevalence of depression/anxiety in RA and their correlation with RA activity. Material and methods Rheumatoid arthritis patients who presented at a rheumatology clinic were selected consecutively. The diagnosis of RA was confirmed by the ACR/EULAR criteria, disease activity was assessed by Dis-ease Activity Score based on the 28-joint count (DAS28) and patients with DAS28 > 2.6 were consid-ered to have active RA. The diagnosis of depression and anxiety was made by the Hospital Anxiety and Depression Scale (HADS). The Pearson test was used to determine the correlation between DAS28 and HADS scores. Results Two-hundred patients (female, 82%) with a mean age of 53.5 ±10.1 years and mean disease dura-tion of 6.6 ±6.8 years were studied. Depression was diagnosed in 27 (13.5%) patients and anxiety in 38 (19%) patients. The DAS28 score correlated positively with depression ( r = 0.173, p = 0.014) and anxiety score ( r = 0.229, p = 0.001). In multiple logistic regression analysis after adjustment for all covariates, age < 40 years and female sex were independently associated with RA activity in patients with depression, with OR = 4.21 ( p = 0.002) and OR = 3.56 ( p = 0.028) respectively. Conclusions These findings indicate that depression and anxiety are prevalent in RA and correlate positively with active disease in particular in depressive female patients aged < 40 years.https://reu.termedia.pl/The-prevalence-and-correlation-of-depression-and-anxiety-with-disease-activity-in,154905,0,2.htmlrheumatoid arthritisdepressionanxietydisease activity score |
| spellingShingle | Sousan Moudi Behzad Heidari Behnaz Yousefghahari Reza Gholami Hemmat Gholinia Mansour Babaei The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis Rheumatology rheumatoid arthritis depression anxiety disease activity score |
| title | The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis |
| title_full | The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis |
| title_fullStr | The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis |
| title_full_unstemmed | The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis |
| title_short | The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis |
| title_sort | prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis |
| topic | rheumatoid arthritis depression anxiety disease activity score |
| url | https://reu.termedia.pl/The-prevalence-and-correlation-of-depression-and-anxiety-with-disease-activity-in,154905,0,2.html |
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