Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation
Neuroinflammatory and neurodegenerative diseases are a major public health problem worldwide, especially with the increase of life-expectancy observed during the last decades. For many of these diseases, we still lack a full understanding of their etiology and pathophysiology. Nonetheless their asso...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.624919/full |
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| author | Lilian Gomes de Oliveira Lilian Gomes de Oliveira Yan de Souza Angelo Yan de Souza Angelo Antonio H. Iglesias Jean Pierre Schatzmann Peron Jean Pierre Schatzmann Peron Jean Pierre Schatzmann Peron |
| author_facet | Lilian Gomes de Oliveira Lilian Gomes de Oliveira Yan de Souza Angelo Yan de Souza Angelo Antonio H. Iglesias Jean Pierre Schatzmann Peron Jean Pierre Schatzmann Peron Jean Pierre Schatzmann Peron |
| author_sort | Lilian Gomes de Oliveira |
| collection | DOAJ |
| description | Neuroinflammatory and neurodegenerative diseases are a major public health problem worldwide, especially with the increase of life-expectancy observed during the last decades. For many of these diseases, we still lack a full understanding of their etiology and pathophysiology. Nonetheless their association with mitochondrial dysfunction highlights this organelle as an important player during CNS homeostasis and disease. Markers of Parkinson (PD) and Alzheimer (AD) diseases are able to induce innate immune pathways induced by alterations in mitochondrial Ca2+ homeostasis leading to neuroinflammation. Additionally, exacerbated type I IFN responses triggered by mitochondrial DNA (mtDNA), failures in mitophagy, ER-mitochondria communication and mtROS production promote neurodegeneration. On the other hand, regulation of mitochondrial dynamics is essential for CNS health maintenance and leading to the induction of IL-10 and reduction of TNF-α secretion, increased cell viability and diminished cell injury in addition to reduced oxidative stress. Thus, although previously solely seen as power suppliers to organelles and molecular processes, it is now well established that mitochondria have many other important roles, including during immune responses. Here, we discuss the importance of these mitochondrial dynamics during neuroinflammation, and how they correlate either with the amelioration or worsening of CNS disease. |
| first_indexed | 2024-12-13T19:09:36Z |
| format | Article |
| id | doaj.art-ef9355be4e4f49d1a8d4c57b5185f183 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T19:09:36Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ef9355be4e4f49d1a8d4c57b5185f1832022-12-21T23:34:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.624919624919Unraveling the Link Between Mitochondrial Dynamics and NeuroinflammationLilian Gomes de Oliveira0Lilian Gomes de Oliveira1Yan de Souza Angelo2Yan de Souza Angelo3Antonio H. Iglesias4Jean Pierre Schatzmann Peron5Jean Pierre Schatzmann Peron6Jean Pierre Schatzmann Peron7Neuroimmune Interactions Laboratory, Immunology Department – Institute of Biomedical Sciences (ICB) IV, University of São Paulo (USP), São Paulo, BrazilNeuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo (USP), São Paulo, BrazilNeuroimmune Interactions Laboratory, Immunology Department – Institute of Biomedical Sciences (ICB) IV, University of São Paulo (USP), São Paulo, BrazilNeuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo (USP), São Paulo, BrazilLoyola University Medical Center, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, United StatesNeuroimmune Interactions Laboratory, Immunology Department – Institute of Biomedical Sciences (ICB) IV, University of São Paulo (USP), São Paulo, BrazilNeuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo (USP), São Paulo, BrazilLoyola University Medical Center, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, United StatesNeuroinflammatory and neurodegenerative diseases are a major public health problem worldwide, especially with the increase of life-expectancy observed during the last decades. For many of these diseases, we still lack a full understanding of their etiology and pathophysiology. Nonetheless their association with mitochondrial dysfunction highlights this organelle as an important player during CNS homeostasis and disease. Markers of Parkinson (PD) and Alzheimer (AD) diseases are able to induce innate immune pathways induced by alterations in mitochondrial Ca2+ homeostasis leading to neuroinflammation. Additionally, exacerbated type I IFN responses triggered by mitochondrial DNA (mtDNA), failures in mitophagy, ER-mitochondria communication and mtROS production promote neurodegeneration. On the other hand, regulation of mitochondrial dynamics is essential for CNS health maintenance and leading to the induction of IL-10 and reduction of TNF-α secretion, increased cell viability and diminished cell injury in addition to reduced oxidative stress. Thus, although previously solely seen as power suppliers to organelles and molecular processes, it is now well established that mitochondria have many other important roles, including during immune responses. Here, we discuss the importance of these mitochondrial dynamics during neuroinflammation, and how they correlate either with the amelioration or worsening of CNS disease.https://www.frontiersin.org/articles/10.3389/fimmu.2021.624919/fullmitochondrianeuroinflammationneurodegenerative diseasesAlzheimer diseaseParkinson diseasemultiple sclerosis |
| spellingShingle | Lilian Gomes de Oliveira Lilian Gomes de Oliveira Yan de Souza Angelo Yan de Souza Angelo Antonio H. Iglesias Jean Pierre Schatzmann Peron Jean Pierre Schatzmann Peron Jean Pierre Schatzmann Peron Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation Frontiers in Immunology mitochondria neuroinflammation neurodegenerative diseases Alzheimer disease Parkinson disease multiple sclerosis |
| title | Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation |
| title_full | Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation |
| title_fullStr | Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation |
| title_full_unstemmed | Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation |
| title_short | Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation |
| title_sort | unraveling the link between mitochondrial dynamics and neuroinflammation |
| topic | mitochondria neuroinflammation neurodegenerative diseases Alzheimer disease Parkinson disease multiple sclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.624919/full |
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