| Summary: | Morphea, also known as localized scleroderma (LoS), comprises a set of autoimmune sclerotic skin diseases. It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved. Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients’ quality of life. Therapy for LoS is often unsatisfactory with numerous treatments that have only limited effectiveness or considerable side effects. Due to the advances in the application of lasers and their possible beneficial effects, the aim of this study is to review the reported usage of laser in morphea. We present a systematic review of available literature, performed with MEDLINE, Cinahl, Central, Scopus, Web of Science, and Google Scholar databases. We identified a total of twenty relevant studies (MEDLINE <i>n</i> = 10, Cinahl <i>n</i> = 1, Central <i>n</i> = 0, Scopus <i>n</i> = 2, Web of Science <i>n</i> = 5, Google Scholar <i>n</i> = 2) using laser therapy for LoS. Eight studies were focused on the use of PDL, six on fractional lasers (CO<sub>2</sub> and Er:YAG), four on excimer, and two on either alexandrite or Nd:YAG.
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