Comparison of antimicrobial properties of inorganic peroxide polymer composites
Abstract Wound healing and prevention of bacterial infections are critical aspects of modern medical care. In this work, antibacterial films were produced by creating composites of polycaprolactone with inorganic peroxides. Calcium, magnesium, and zinc peroxide were incorporated in a biocompatible p...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
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| Series: | MedComm – Biomaterials and Applications |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mba2.75 |
| _version_ | 1827314651157757952 |
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| author | Dario Job Justin Matta Cat‐Thy Dang Yara Raphael Joshua Vorstenbosch Bentolhoda Helli Geraldine Merle Jake Barralet |
| author_facet | Dario Job Justin Matta Cat‐Thy Dang Yara Raphael Joshua Vorstenbosch Bentolhoda Helli Geraldine Merle Jake Barralet |
| author_sort | Dario Job |
| collection | DOAJ |
| description | Abstract Wound healing and prevention of bacterial infections are critical aspects of modern medical care. In this work, antibacterial films were produced by creating composites of polycaprolactone with inorganic peroxides. Calcium, magnesium, and zinc peroxide were incorporated in a biocompatible polymeric film. Iron oxide, sodium bicarbonate, and calcium phosphate were added to reduce hydrogen peroxide and to maintain pH in a less alkaline range, allowing for optimization of the material's antibacterial efficacy while minimizing cytotoxicity toward human fibroblasts. Experiments with common wound pathogens, Staphylococcus aureus and Pseudomonas aerugonisa, confirmed significant and prolonged antibacterial effects of peroxide‐doped films. Findings showed that the addition of CaO2 and MgO2 within the film increased cytotoxicity toward human fibroblasts after 48 h (30%–40% decrease compared to control), whereas ZnO2‐based films exhibited a minimal cytotoxicity consistently maintaining over 70% cell viability throughout the course of the experiment. We examined the materials’ sustained release of reactive oxygen species and oxygen, and pH variation correlated with antibacterial activity. Given the unique combination of antibacterial efficacy and mammalian biocompatibility, these peroxides have value as components to sustain hydrogen peroxide release when appropriately compounded to reduce pH variation and avoid excessive hydrogen peroxide levels. |
| first_indexed | 2024-04-24T22:41:01Z |
| format | Article |
| id | doaj.art-ef9964dad3484547a31e4ff0ef3eb2c2 |
| institution | Directory Open Access Journal |
| issn | 2769-643X |
| language | English |
| last_indexed | 2024-04-24T22:41:01Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Biomaterials and Applications |
| spelling | doaj.art-ef9964dad3484547a31e4ff0ef3eb2c22024-03-19T05:24:26ZengWileyMedComm – Biomaterials and Applications2769-643X2024-03-0131n/an/a10.1002/mba2.75Comparison of antimicrobial properties of inorganic peroxide polymer compositesDario Job0Justin Matta1Cat‐Thy Dang2Yara Raphael3Joshua Vorstenbosch4Bentolhoda Helli5Geraldine Merle6Jake Barralet7Chemical Engineering Department Polytechnique Montreal Québec CanadaDepartment of Surgery, Division of Surgical and Interventional Sciences McGill University Montreal Québec CanadaChemical Engineering Department Polytechnique Montreal Québec CanadaChemical Engineering Department Polytechnique Montreal Québec CanadaDepartment of Surgery, Division of Surgical and Interventional Sciences McGill University Montreal Québec CanadaChemical Engineering Department Polytechnique Montreal Québec CanadaChemical Engineering Department Polytechnique Montreal Québec CanadaDepartment of Surgery, Division of Surgical and Interventional Sciences McGill University Montreal Québec CanadaAbstract Wound healing and prevention of bacterial infections are critical aspects of modern medical care. In this work, antibacterial films were produced by creating composites of polycaprolactone with inorganic peroxides. Calcium, magnesium, and zinc peroxide were incorporated in a biocompatible polymeric film. Iron oxide, sodium bicarbonate, and calcium phosphate were added to reduce hydrogen peroxide and to maintain pH in a less alkaline range, allowing for optimization of the material's antibacterial efficacy while minimizing cytotoxicity toward human fibroblasts. Experiments with common wound pathogens, Staphylococcus aureus and Pseudomonas aerugonisa, confirmed significant and prolonged antibacterial effects of peroxide‐doped films. Findings showed that the addition of CaO2 and MgO2 within the film increased cytotoxicity toward human fibroblasts after 48 h (30%–40% decrease compared to control), whereas ZnO2‐based films exhibited a minimal cytotoxicity consistently maintaining over 70% cell viability throughout the course of the experiment. We examined the materials’ sustained release of reactive oxygen species and oxygen, and pH variation correlated with antibacterial activity. Given the unique combination of antibacterial efficacy and mammalian biocompatibility, these peroxides have value as components to sustain hydrogen peroxide release when appropriately compounded to reduce pH variation and avoid excessive hydrogen peroxide levels.https://doi.org/10.1002/mba2.75bacteriahydrogen peroxideinorganicoxygenperoxidewound |
| spellingShingle | Dario Job Justin Matta Cat‐Thy Dang Yara Raphael Joshua Vorstenbosch Bentolhoda Helli Geraldine Merle Jake Barralet Comparison of antimicrobial properties of inorganic peroxide polymer composites MedComm – Biomaterials and Applications bacteria hydrogen peroxide inorganic oxygen peroxide wound |
| title | Comparison of antimicrobial properties of inorganic peroxide polymer composites |
| title_full | Comparison of antimicrobial properties of inorganic peroxide polymer composites |
| title_fullStr | Comparison of antimicrobial properties of inorganic peroxide polymer composites |
| title_full_unstemmed | Comparison of antimicrobial properties of inorganic peroxide polymer composites |
| title_short | Comparison of antimicrobial properties of inorganic peroxide polymer composites |
| title_sort | comparison of antimicrobial properties of inorganic peroxide polymer composites |
| topic | bacteria hydrogen peroxide inorganic oxygen peroxide wound |
| url | https://doi.org/10.1002/mba2.75 |
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