Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice

Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice

Abstract Background Liver fibrosis is an outcome of restoring process in chronic liver injury. Human amniotic mesenchymal stem cells (hAMSCs) derived from amniotic membrane have multilineage differentiation, immunosuppressive, and anti-inflammatory potential which makes them suitable for treating li...

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Bibliographic Details
Main Authors:	Quan-Wen Liu, Yan-Min Ying, Jia-Xin Zhou, Wen-Jie Zhang, Zhao-xiao Liu, Bing-Bing Jia, Hao-Cheng Gu, Chu-Yu Zhao, Xiao-Hui Guan, Ke-Yu Deng, Hong-Bo Xin
Format:	Article
Language:	English
Published:	BMC 2022-06-01
Series:	Stem Cell Research & Therapy
Subjects:	Liver fibrosis Human amniotic mesenchymal stem cells Hepatic stellate cell Antibody array Wnt/β-catenin signaling pathway
Online Access:	https://doi.org/10.1186/s13287-022-02906-z

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