Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review
Many clinical diseases are accompanied by the symptoms of pain, and the degree of pain is closely related to the patients’ suffering. Therefore, effectively relieving pain has become one of the vital concerns of clinical treatment and analgesic drug research. Non-opioid drugs are mainly used for the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-11-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/30212 |
| _version_ | 1797765371495710720 |
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| author | Ruizhou Wang Lu Han Qixia Gao Dan Chen Yun Wang Xia Zhang Xin Yu Yueming Zhang Zhiyong Li Changcai Bai |
| author_facet | Ruizhou Wang Lu Han Qixia Gao Dan Chen Yun Wang Xia Zhang Xin Yu Yueming Zhang Zhiyong Li Changcai Bai |
| author_sort | Ruizhou Wang |
| collection | DOAJ |
| description | Many clinical diseases are accompanied by the symptoms of pain, and the degree of pain is closely related to the patients’ suffering. Therefore, effectively relieving pain has become one of the vital concerns of clinical treatment and analgesic drug research. Non-opioid drugs are mainly used for the clinical treatment of mild to moderate pain, whereas opioid drugs are mainly used for treating moderate to severe pain. However, opioid drugs easily elicit adverse reactions, such as gastrointestinal discomfort, addiction, dependence, and so on. Traditional Chinese medicine and its active ingredients have unique advantages in the treatment of pain for quite a long time, and many analgesic drugs directly or indirectly were isolatiedfrom Chinese medicine or natural products, such as Liu Suan Yan Hu Suo Yi Su Pian and aspirin. With the development and modernization of research on herbal medicine more and more studies have been conducted on the active ingredients and mechanisms of traditional Chinese medicine analgesics. However, no review has been done on analgesic active components and their mechanisms. In this paper, 81 active components with clear chemical structure and definite analgesic effects in vivo and in vitro of traditional Chinese medicine and mechanisms of action reported in recent literatures are reviewed and summarized to provide reference for clinical analgesia and analgesics research. |
| first_indexed | 2024-03-12T20:09:12Z |
| format | Article |
| id | doaj.art-ef9a6373ed0847a38f19b3aa06075b56 |
| institution | Directory Open Access Journal |
| issn | 1482-1826 |
| language | English |
| last_indexed | 2024-03-12T20:09:12Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmaceutical Sciences |
| spelling | doaj.art-ef9a6373ed0847a38f19b3aa06075b562023-08-02T01:52:46ZengFrontiers Media S.A.Journal of Pharmacy & Pharmaceutical Sciences1482-18262018-11-0121110.18433/jpps30212Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive ReviewRuizhou Wang0Lu Han1Qixia Gao2Dan Chen3Yun Wang4Xia Zhang5Xin Yu6Yueming Zhang7Zhiyong Li8Changcai Bai9Key Laboratory of Hui Medicine Modernization, Ningxia Medical University Pharmacy College, Yinchuan, P. R. China.Key Laboratory of Hui Medicine Modernization, Ningxia Medical University Pharmacy College, Yinchuan, P. R. China.College of Pharmacy, Minzu University of China, Beijing, P. R. China.General Hospital of Ningxia Medical University, Yinchuan, P. R. China.Institute of Chinese Materia Medica, China academy of Chinese medical sciences, Beijing, P. R. China.Key Laboratory of Hui Medicine Modernization, Ningxia Medical University Pharmacy College, Yinchuan, P. R. China.Key Laboratory of Hui Medicine Modernization, Ningxia Medical University Pharmacy College, Yinchuan, P. R. China.Key Laboratory of Hui Medicine Modernization, Ningxia Medical University Pharmacy College, Yinchuan, P. R. China.College of Pharmacy, Minzu University of China, Beijing, P. R. China.Key Laboratory of Hui Medicine Modernization, Ningxia Medical University Pharmacy College, Yinchuan, P. R. China.Many clinical diseases are accompanied by the symptoms of pain, and the degree of pain is closely related to the patients’ suffering. Therefore, effectively relieving pain has become one of the vital concerns of clinical treatment and analgesic drug research. Non-opioid drugs are mainly used for the clinical treatment of mild to moderate pain, whereas opioid drugs are mainly used for treating moderate to severe pain. However, opioid drugs easily elicit adverse reactions, such as gastrointestinal discomfort, addiction, dependence, and so on. Traditional Chinese medicine and its active ingredients have unique advantages in the treatment of pain for quite a long time, and many analgesic drugs directly or indirectly were isolatiedfrom Chinese medicine or natural products, such as Liu Suan Yan Hu Suo Yi Su Pian and aspirin. With the development and modernization of research on herbal medicine more and more studies have been conducted on the active ingredients and mechanisms of traditional Chinese medicine analgesics. However, no review has been done on analgesic active components and their mechanisms. In this paper, 81 active components with clear chemical structure and definite analgesic effects in vivo and in vitro of traditional Chinese medicine and mechanisms of action reported in recent literatures are reviewed and summarized to provide reference for clinical analgesia and analgesics research.https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/30212 |
| spellingShingle | Ruizhou Wang Lu Han Qixia Gao Dan Chen Yun Wang Xia Zhang Xin Yu Yueming Zhang Zhiyong Li Changcai Bai Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review Journal of Pharmacy & Pharmaceutical Sciences |
| title | Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review |
| title_full | Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review |
| title_fullStr | Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review |
| title_full_unstemmed | Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review |
| title_short | Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review |
| title_sort | progress on active analgesic components and mechanisms of commonly used traditional chinese medicines a comprehensive review |
| url | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/30212 |
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