Effect of Penetration Enhancers and Safety on the Transdermal Delivery of Apremilast in Skin

Effect of Penetration Enhancers and Safety on the Transdermal Delivery of Apremilast in Skin

The poor water solubility of apremilast (APR) is the main impediment to the penetration of the drug through the skin barrier. The objective of this study was to evaluate the permeability of APR in different solutions enriched with penetration promoters in ex vivo samples of human skin, and additiona...

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Bibliographic Details
Main Authors: Paulo Sarango-Granda, Lupe Carolina Espinoza, Natalia Díaz-Garrido, Helen Alvarado, María J. Rodríguez-Lagunas, Laura Baldomá, Ana Calpena
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
apremilast
squalene
skin
promoter
Online Access:https://www.mdpi.com/1999-4923/14/5/1011

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