Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012
Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A–C (3–5), isolated from the fermentation super...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/5/1524 |
| _version_ | 1828347544841748480 |
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| author | Ying Huang Lijun Xi Fei Shang Ning Liu |
| author_facet | Ying Huang Lijun Xi Fei Shang Ning Liu |
| author_sort | Ying Huang |
| collection | DOAJ |
| description | Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A–C (3–5), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn2+ complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae. |
| first_indexed | 2024-04-14T00:41:00Z |
| format | Article |
| id | doaj.art-ef9baf31302745229326ccfd60d5b08e |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T00:41:00Z |
| publishDate | 2013-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ef9baf31302745229326ccfd60d5b08e2022-12-22T02:22:11ZengMDPI AGMarine Drugs1660-33972013-05-011151524153310.3390/md11051524Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012Ying HuangLijun XiFei ShangNing LiuTwo new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A–C (3–5), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn2+ complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae.http://www.mdpi.com/1660-3397/11/5/1524deep-sea waterStreptomyces olivaceustetroazolemycinsiderophore |
| spellingShingle | Ying Huang Lijun Xi Fei Shang Ning Liu Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012 Marine Drugs deep-sea water Streptomyces olivaceus tetroazolemycin siderophore |
| title | Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012 |
| title_full | Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012 |
| title_fullStr | Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012 |
| title_full_unstemmed | Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012 |
| title_short | Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012 |
| title_sort | tetroazolemycins a and b two new oxazole thiazole siderophores from deep sea streptomyces olivaceus fxj8 012 |
| topic | deep-sea water Streptomyces olivaceus tetroazolemycin siderophore |
| url | http://www.mdpi.com/1660-3397/11/5/1524 |
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