The Effect of CYP2D6 Phenotypes on the Pharmacokinetics of Propafenone: A Systematic Review and Meta-Analysis

The Effect of CYP2D6 Phenotypes on the Pharmacokinetics of Propafenone: A Systematic Review and Meta-Analysis

Propafenone (PPF) is a class 1C antiarrhythmic agent mainly metabolized by cytochrome (CYP) 2D6, CYP1A2, and CYP3A4. Previous studies have shown that CYP2D6 polymorphism influences the pharmacokinetics (PK) of PPF. However, the small sample sizes of PK studies can lead to less precise estimates of t...

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Bibliographic Details
Main Authors: Quyen Thi Tran, In-hwan Baek, Na-young Han, Hwi-yeol Yun, Jung-woo Chae
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
propafenone
pharmacokinetics
phenotype
CYP2D6
precision medicine
Online Access:https://www.mdpi.com/1999-4923/14/7/1446

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