Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning
The mechanisms underpinning the variability in methylphenidate’s effects on cognition remain unclear. Here, the authors show that such effects reflect changes in striatal dopamine-related output gating of task-relevant cortical signals, and that these changes depend on baseline dopamine synthesis ca...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32679-1 |
| _version_ | 1828356488963293184 |
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| author | Ruben van den Bosch Britt Lambregts Jessica Määttä Lieke Hofmans Danae Papadopetraki Andrew Westbrook Robbert-Jan Verkes Jan Booij Roshan Cools |
| author_facet | Ruben van den Bosch Britt Lambregts Jessica Määttä Lieke Hofmans Danae Papadopetraki Andrew Westbrook Robbert-Jan Verkes Jan Booij Roshan Cools |
| author_sort | Ruben van den Bosch |
| collection | DOAJ |
| description | The mechanisms underpinning the variability in methylphenidate’s effects on cognition remain unclear. Here, the authors show that such effects reflect changes in striatal dopamine-related output gating of task-relevant cortical signals, and that these changes depend on baseline dopamine synthesis capacity. |
| first_indexed | 2024-04-14T03:00:55Z |
| format | Article |
| id | doaj.art-ef9fb96be66e426799482229f2ee9645 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T03:00:55Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ef9fb96be66e426799482229f2ee96452022-12-22T02:15:56ZengNature PortfolioNature Communications2041-17232022-08-0113111510.1038/s41467-022-32679-1Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learningRuben van den Bosch0Britt Lambregts1Jessica Määttä2Lieke Hofmans3Danae Papadopetraki4Andrew Westbrook5Robbert-Jan Verkes6Jan Booij7Roshan Cools8Radboud University, Donders Institute for Brain, Cognition and BehaviourRadboud University Medical Center, Department of Psychiatry, Donders Institute for Brain, Cognition and BehaviourDepartment of Clinical Neuroscience, Karolinska InstitutetDepartment of Developmental Psychology, University of AmsterdamRadboud University Medical Center, Department of Psychiatry, Donders Institute for Brain, Cognition and BehaviourCognitive, Linguistic & Psychological Sciences Department, Brown UniversityRadboud University Medical Center, Department of Psychiatry, Donders Institute for Brain, Cognition and BehaviourDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location Academic Medical CenterRadboud University Medical Center, Department of Psychiatry, Donders Institute for Brain, Cognition and BehaviourThe mechanisms underpinning the variability in methylphenidate’s effects on cognition remain unclear. Here, the authors show that such effects reflect changes in striatal dopamine-related output gating of task-relevant cortical signals, and that these changes depend on baseline dopamine synthesis capacity.https://doi.org/10.1038/s41467-022-32679-1 |
| spellingShingle | Ruben van den Bosch Britt Lambregts Jessica Määttä Lieke Hofmans Danae Papadopetraki Andrew Westbrook Robbert-Jan Verkes Jan Booij Roshan Cools Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning Nature Communications |
| title | Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning |
| title_full | Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning |
| title_fullStr | Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning |
| title_full_unstemmed | Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning |
| title_short | Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning |
| title_sort | striatal dopamine dissociates methylphenidate effects on value based versus surprise based reversal learning |
| url | https://doi.org/10.1038/s41467-022-32679-1 |
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