Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance
Aims: The aim was to study the effect of family history of type 2 diabetes mellitus (T2DM) on insulin sensitivity and b-cell function in normoglycemic offspring. Material and Methods: Offspring of T2DM patients (cases) and individuals without family history of T2DM (controls) were the subjects for t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=1;spage=105;epage=111;aulast=Praveen |
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| author | Edavan P Praveen Jayaprakash Sahoo Madan L Khurana Bindu Kulshreshtha Rajesh Khadgawat Nandita Gupta Sada Nand Dwivedi Guresh Kumar Dorairaj Prabhakaran Ariachery C Ammini |
| author_facet | Edavan P Praveen Jayaprakash Sahoo Madan L Khurana Bindu Kulshreshtha Rajesh Khadgawat Nandita Gupta Sada Nand Dwivedi Guresh Kumar Dorairaj Prabhakaran Ariachery C Ammini |
| author_sort | Edavan P Praveen |
| collection | DOAJ |
| description | Aims: The aim was to study the effect of family history of type 2 diabetes mellitus (T2DM) on insulin sensitivity and b-cell function in normoglycemic offspring. Material and Methods: Offspring of T2DM patients (cases) and individuals without family history of T2DM (controls) were the subjects for this cross-sectional study. All participants underwent 75 g OGTT and samples were collected for plasma insulin, C-peptide, and proinsulin at 0, 30, 60, and 120 minutes. Results: A total of 271 cases (age 22 ± 10 years; 53% males) and 259 controls (28 ± 10 years, 66% males) were enrolled for the study. BMI, plasma insulin, C-peptide, proinsulin, HOMA-IR, and insulinogenic index (0-120) were significantly higher and whole-body insulin sensitivity (WBISI) and disposition index (0-120) [DI 120] were lower in cases compared to controls. After adjusting for BMI, proinsulin at 120 minutes, area under the curve (AUC) of proinsulin (during OGTT) and AUC proinsulin/AUC C-peptide were significantly higher in cases. Cases were subdivided into four groups according to inheritance pattern; paternal DM (PDM), maternal DM (MDM), grandparental DM (GPDM), and both parents DM (BPDM). The magnitude of differences varied with relationship (greater when both parents and grandparents were affected). Mean HOMA-IR was higher by 127% and 50% and DI 120 was lower by 33% and 18% (adjusted for age and gender) in the BPDM and GPDM groups respectively compared to controls. Conclusions: We observed higher BMI, plasma insulin, C-peptide, and proinsulin and lower insulin sensitivity and b-cell compensation in normoglycemic offspring of T2DM subjects compared to controls. Differences were greater when both parents and grandparents had T2DM. |
| first_indexed | 2024-12-21T12:54:21Z |
| format | Article |
| id | doaj.art-efa060ff9e31466e9c5891ad9789bb14 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-21T12:54:21Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-efa060ff9e31466e9c5891ad9789bb142022-12-21T19:03:23ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002012-01-0116110511110.4103/2230-8210.91204Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritanceEdavan P PraveenJayaprakash SahooMadan L KhuranaBindu KulshreshthaRajesh KhadgawatNandita GuptaSada Nand DwivediGuresh KumarDorairaj PrabhakaranAriachery C AmminiAims: The aim was to study the effect of family history of type 2 diabetes mellitus (T2DM) on insulin sensitivity and b-cell function in normoglycemic offspring. Material and Methods: Offspring of T2DM patients (cases) and individuals without family history of T2DM (controls) were the subjects for this cross-sectional study. All participants underwent 75 g OGTT and samples were collected for plasma insulin, C-peptide, and proinsulin at 0, 30, 60, and 120 minutes. Results: A total of 271 cases (age 22 ± 10 years; 53% males) and 259 controls (28 ± 10 years, 66% males) were enrolled for the study. BMI, plasma insulin, C-peptide, proinsulin, HOMA-IR, and insulinogenic index (0-120) were significantly higher and whole-body insulin sensitivity (WBISI) and disposition index (0-120) [DI 120] were lower in cases compared to controls. After adjusting for BMI, proinsulin at 120 minutes, area under the curve (AUC) of proinsulin (during OGTT) and AUC proinsulin/AUC C-peptide were significantly higher in cases. Cases were subdivided into four groups according to inheritance pattern; paternal DM (PDM), maternal DM (MDM), grandparental DM (GPDM), and both parents DM (BPDM). The magnitude of differences varied with relationship (greater when both parents and grandparents were affected). Mean HOMA-IR was higher by 127% and 50% and DI 120 was lower by 33% and 18% (adjusted for age and gender) in the BPDM and GPDM groups respectively compared to controls. Conclusions: We observed higher BMI, plasma insulin, C-peptide, and proinsulin and lower insulin sensitivity and b-cell compensation in normoglycemic offspring of T2DM subjects compared to controls. Differences were greater when both parents and grandparents had T2DM.http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=1;spage=105;epage=111;aulast=Praveenβ-cell functiongrandparental history of DMinsulin sensitivitynormoglycemicoffspring of individuals with type 2 diabetes |
| spellingShingle | Edavan P Praveen Jayaprakash Sahoo Madan L Khurana Bindu Kulshreshtha Rajesh Khadgawat Nandita Gupta Sada Nand Dwivedi Guresh Kumar Dorairaj Prabhakaran Ariachery C Ammini Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance Indian Journal of Endocrinology and Metabolism β-cell function grandparental history of DM insulin sensitivity normoglycemic offspring of individuals with type 2 diabetes |
| title | Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance |
| title_full | Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance |
| title_fullStr | Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance |
| title_full_unstemmed | Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance |
| title_short | Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance |
| title_sort | insulin sensitivity and β cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus impact of line of inheritance |
| topic | β-cell function grandparental history of DM insulin sensitivity normoglycemic offspring of individuals with type 2 diabetes |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=1;spage=105;epage=111;aulast=Praveen |
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