Improving Co-Amorphous Drug Formulations by the Addition of the Highly Water Soluble Amino Acid, Proline

Improving Co-Amorphous Drug Formulations by the Addition of the Highly Water Soluble Amino Acid, Proline

Co-amorphous drug amino acid mixtures were previously shown to be a promising approach to create physically stable amorphous systems with the improved dissolution properties of poorly water-soluble drugs. The aim of this work was to expand the co-amorphous drug amino acid mixture approach by combin...

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Bibliographic Details
Main Authors: Katrine Tarp Jensen, Korbinian Löbmann, Thomas Rades, Holger Grohganz
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Pharmaceutics
Subjects:
amino acid
co-amorphous
dissolution rate
DSC
FTIR
salt formation
solid state analysis
stability
XRPD
Online Access:http://www.mdpi.com/1999-4923/6/3/416

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