Motility of the Zoonotic Spirochete <i>Leptospira</i>: Insight into Association with Pathogenicity
If a bacterium has motility, it will use the ability to survive and thrive. For many pathogenic species, their motilities are a crucial virulence factor. The form of motility varies among the species. Some use flagella for swimming in liquid, and others use the cell-surface machinery to move over so...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1859 |
| _version_ | 1797487138047000576 |
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| author | Shuichi Nakamura |
| author_facet | Shuichi Nakamura |
| author_sort | Shuichi Nakamura |
| collection | DOAJ |
| description | If a bacterium has motility, it will use the ability to survive and thrive. For many pathogenic species, their motilities are a crucial virulence factor. The form of motility varies among the species. Some use flagella for swimming in liquid, and others use the cell-surface machinery to move over solid surfaces. Spirochetes are distinguished from other bacterial species by their helical or flat wave morphology and periplasmic flagella (PFs). It is believed that the rotation of PFs beneath the outer membrane causes transformation or rolling of the cell body, propelling the spirochetes. Interestingly, some spirochetal species exhibit motility both in liquid and over surfaces, but it is not fully unveiled how the spirochete pathogenicity involves such amphibious motility. This review focuses on the causative agent of zoonosis leptospirosis and discusses the significance of their motility in liquid and on surfaces, called crawling, as a virulence factor. |
| first_indexed | 2024-03-09T23:44:19Z |
| format | Article |
| id | doaj.art-efa6477426cd4cacaf560996639d6e0c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:44:19Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-efa6477426cd4cacaf560996639d6e0c2023-11-23T16:47:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01233185910.3390/ijms23031859Motility of the Zoonotic Spirochete <i>Leptospira</i>: Insight into Association with PathogenicityShuichi Nakamura0Department of Applied Physics, Graduate School of Engineering, Tohoku University, 6-6-05 Aoba, Aoba-ku, Sendai 980-8579, JapanIf a bacterium has motility, it will use the ability to survive and thrive. For many pathogenic species, their motilities are a crucial virulence factor. The form of motility varies among the species. Some use flagella for swimming in liquid, and others use the cell-surface machinery to move over solid surfaces. Spirochetes are distinguished from other bacterial species by their helical or flat wave morphology and periplasmic flagella (PFs). It is believed that the rotation of PFs beneath the outer membrane causes transformation or rolling of the cell body, propelling the spirochetes. Interestingly, some spirochetal species exhibit motility both in liquid and over surfaces, but it is not fully unveiled how the spirochete pathogenicity involves such amphibious motility. This review focuses on the causative agent of zoonosis leptospirosis and discusses the significance of their motility in liquid and on surfaces, called crawling, as a virulence factor.https://www.mdpi.com/1422-0067/23/3/1859bacteriamotilityspirochete<i>Leptospira</i>leptospirosisvirulence factor |
| spellingShingle | Shuichi Nakamura Motility of the Zoonotic Spirochete <i>Leptospira</i>: Insight into Association with Pathogenicity International Journal of Molecular Sciences bacteria motility spirochete <i>Leptospira</i> leptospirosis virulence factor |
| title | Motility of the Zoonotic Spirochete <i>Leptospira</i>: Insight into Association with Pathogenicity |
| title_full | Motility of the Zoonotic Spirochete <i>Leptospira</i>: Insight into Association with Pathogenicity |
| title_fullStr | Motility of the Zoonotic Spirochete <i>Leptospira</i>: Insight into Association with Pathogenicity |
| title_full_unstemmed | Motility of the Zoonotic Spirochete <i>Leptospira</i>: Insight into Association with Pathogenicity |
| title_short | Motility of the Zoonotic Spirochete <i>Leptospira</i>: Insight into Association with Pathogenicity |
| title_sort | motility of the zoonotic spirochete i leptospira i insight into association with pathogenicity |
| topic | bacteria motility spirochete <i>Leptospira</i> leptospirosis virulence factor |
| url | https://www.mdpi.com/1422-0067/23/3/1859 |
| work_keys_str_mv | AT shuichinakamura motilityofthezoonoticspirocheteileptospiraiinsightintoassociationwithpathogenicity |