Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors

Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors

The term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell population with a count of less than 5 × 109/L and no symptoms or signs of disease. Based on the B cell count, MBL is further classified into 2 distinct subtypes: ‘low-count’ and ‘high-count’ MBL. High-count MBL...

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Bibliographic Details
Main Authors: Chrysi Galigalidou, Laura Zaragoza-Infante, Anastasia Iatrou, Anastasia Chatzidimitriou, Kostas Stamatopoulos, Andreas Agathangelidis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
monoclonal B cell lymphocytosis (MBL)
chronic Lymphocutic Leukemia (CLL)
genetics
immunogenetics
tumor microenvironment
ontogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.769612/full

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