Fibromuscular dysplasia of aortic aneurysm vasa vasorum (a rare case report)
Aim. To describe a rare occurrence of fibromuscular vasa vasorum dysplasia of the aortic aneurysm wall.Materials and methods. Surgical material from the ascending aortic aneurysm wall was examined. Longitudinal strips of the aortic wall were excised for histological examination with subsequent 24-h fi...
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2020-08-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/2297 |
| _version_ | 1797295443407798272 |
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| author | S. S. Todorov V. Yu. Deribas A. S. Kaz’min S. S. Todorov |
| author_facet | S. S. Todorov V. Yu. Deribas A. S. Kaz’min S. S. Todorov |
| author_sort | S. S. Todorov |
| collection | DOAJ |
| description | Aim. To describe a rare occurrence of fibromuscular vasa vasorum dysplasia of the aortic aneurysm wall.Materials and methods. Surgical material from the ascending aortic aneurysm wall was examined. Longitudinal strips of the aortic wall were excised for histological examination with subsequent 24-h fixation in 10% buffered formalin. A histological isopropanol assay was performed with an automated Logos microwave tissue processor (Milestone, Italy) with subsequent sample embedding into paraffin. Sections were obtained with a rotary microtome (Leica, Germany). Staining was performed with haematoxylin-eosin, van Gieson’s picrofuchsin, orcein for elastic fibres, Hotchkiss’ PAS reaction with alcian blue for glycosaminoglycans. Histological and histochemical properties of the aortic wall were studied and imaged with a Leica DM 1000 microscope (Germany) equipped with a camera ICC50 E at magnifications 40x, 100x, 200x, 400x.Results. The conducted histological examination of the aortic aneurysm wall revealed most pronounced changes in media and adventitia layers. Elastic fibres in media were swollen, homogeneous, crimped, with pronounced dystrophic and necrobiotic changes in smooth myocytes. Regions of compromised cells and elastic fibres in media contained pockets of alcian-positive glycosaminoglycans. Specific changes were revealed in adventitia vasa vasorum in the form of a pronounced wall thickening and lumen narrowing due to dysplastic fibromuscular tissues.Conclusion. A rare form of fibromuscular dysplasia of the vasa vasorum of the ascending aortic aneurysm wall observed in a 43 years-old woman demonstrated the morbid morphology of smooth myocytes, as well as fibrous collagenous and elastic structures. The described features were likely associated with the aortic wall trophic structure and aneurysm morphogenesis. |
| first_indexed | 2024-03-07T21:48:00Z |
| format | Article |
| id | doaj.art-efa6cb03317d4ac48f7236e18b737418 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2024-03-07T21:48:00Z |
| publishDate | 2020-08-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-efa6cb03317d4ac48f7236e18b7374182024-02-25T10:57:25ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442020-08-0127416917810.25207/1608-6228-2020-27-4-169-1781204Fibromuscular dysplasia of aortic aneurysm vasa vasorum (a rare case report)S. S. Todorov0V. Yu. Deribas1A. S. Kaz’min2S. S. Todorov3Rostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityAim. To describe a rare occurrence of fibromuscular vasa vasorum dysplasia of the aortic aneurysm wall.Materials and methods. Surgical material from the ascending aortic aneurysm wall was examined. Longitudinal strips of the aortic wall were excised for histological examination with subsequent 24-h fixation in 10% buffered formalin. A histological isopropanol assay was performed with an automated Logos microwave tissue processor (Milestone, Italy) with subsequent sample embedding into paraffin. Sections were obtained with a rotary microtome (Leica, Germany). Staining was performed with haematoxylin-eosin, van Gieson’s picrofuchsin, orcein for elastic fibres, Hotchkiss’ PAS reaction with alcian blue for glycosaminoglycans. Histological and histochemical properties of the aortic wall were studied and imaged with a Leica DM 1000 microscope (Germany) equipped with a camera ICC50 E at magnifications 40x, 100x, 200x, 400x.Results. The conducted histological examination of the aortic aneurysm wall revealed most pronounced changes in media and adventitia layers. Elastic fibres in media were swollen, homogeneous, crimped, with pronounced dystrophic and necrobiotic changes in smooth myocytes. Regions of compromised cells and elastic fibres in media contained pockets of alcian-positive glycosaminoglycans. Specific changes were revealed in adventitia vasa vasorum in the form of a pronounced wall thickening and lumen narrowing due to dysplastic fibromuscular tissues.Conclusion. A rare form of fibromuscular dysplasia of the vasa vasorum of the ascending aortic aneurysm wall observed in a 43 years-old woman demonstrated the morbid morphology of smooth myocytes, as well as fibrous collagenous and elastic structures. The described features were likely associated with the aortic wall trophic structure and aneurysm morphogenesis.https://ksma.elpub.ru/jour/article/view/2297aortic aneurysmfibromuscular dysplasiamorphologyadventitia vasa vasorum |
| spellingShingle | S. S. Todorov V. Yu. Deribas A. S. Kaz’min S. S. Todorov Fibromuscular dysplasia of aortic aneurysm vasa vasorum (a rare case report) Кубанский научный медицинский вестник aortic aneurysm fibromuscular dysplasia morphology adventitia vasa vasorum |
| title | Fibromuscular dysplasia of aortic aneurysm vasa vasorum (a rare case report) |
| title_full | Fibromuscular dysplasia of aortic aneurysm vasa vasorum (a rare case report) |
| title_fullStr | Fibromuscular dysplasia of aortic aneurysm vasa vasorum (a rare case report) |
| title_full_unstemmed | Fibromuscular dysplasia of aortic aneurysm vasa vasorum (a rare case report) |
| title_short | Fibromuscular dysplasia of aortic aneurysm vasa vasorum (a rare case report) |
| title_sort | fibromuscular dysplasia of aortic aneurysm vasa vasorum a rare case report |
| topic | aortic aneurysm fibromuscular dysplasia morphology adventitia vasa vasorum |
| url | https://ksma.elpub.ru/jour/article/view/2297 |
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