Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study
Abstract Background Some studies have shown that gut microbiota may be associated with dementia. However, the causal effects between gut microbiota and different types of dementia and whether cytokines act as a mediator remain unclear. Methods Gut microbiota, cytokines, and five dementia types, incl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-023-02999-0 |
| _version_ | 1827388303823863808 |
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| author | Dong Ji Wen-Zhu Chen Lei Zhang Zhi-Hua Zhang Li-Jian Chen |
| author_facet | Dong Ji Wen-Zhu Chen Lei Zhang Zhi-Hua Zhang Li-Jian Chen |
| author_sort | Dong Ji |
| collection | DOAJ |
| description | Abstract Background Some studies have shown that gut microbiota may be associated with dementia. However, the causal effects between gut microbiota and different types of dementia and whether cytokines act as a mediator remain unclear. Methods Gut microbiota, cytokines, and five dementia types, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), dementia with Lewy body (DLB), vascular dementia (VD), and Parkinson’s disease dementia (PDD) were identified from large-scale genome-wide association studies (GWAS) summary data. We used Mendelian randomization (MR) to investigate the causal relationships between gut microbiota, cytokines, and five types of dementia. Inverse variance weighting (IVW) was used as the main statistical method. In addition, we explored whether cytokines act as a mediating factor in the pathway from gut microbiota to dementia. Results There were 20 positive and 16 negative causal effects between genetic liability in the gut microbiota and dementia. Also, there were five positive and four negative causal effects between cytokines and dementias. Cytokines did not act as mediating factors. Conclusions Gut microbiota and cytokines were causally associated with five types of dementia, and cytokines seemed not to be the mediating factors in the pathway from gut microbiota to dementia. |
| first_indexed | 2024-03-08T16:15:48Z |
| format | Article |
| id | doaj.art-efa73d73231e427e93072ec686d32336 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-03-08T16:15:48Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-efa73d73231e427e93072ec686d323362024-01-07T12:37:20ZengBMCJournal of Neuroinflammation1742-20942024-01-0121111010.1186/s12974-023-02999-0Gut microbiota, circulating cytokines and dementia: a Mendelian randomization studyDong Ji0Wen-Zhu Chen1Lei Zhang2Zhi-Hua Zhang3Li-Jian Chen4Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical UniversityAbstract Background Some studies have shown that gut microbiota may be associated with dementia. However, the causal effects between gut microbiota and different types of dementia and whether cytokines act as a mediator remain unclear. Methods Gut microbiota, cytokines, and five dementia types, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), dementia with Lewy body (DLB), vascular dementia (VD), and Parkinson’s disease dementia (PDD) were identified from large-scale genome-wide association studies (GWAS) summary data. We used Mendelian randomization (MR) to investigate the causal relationships between gut microbiota, cytokines, and five types of dementia. Inverse variance weighting (IVW) was used as the main statistical method. In addition, we explored whether cytokines act as a mediating factor in the pathway from gut microbiota to dementia. Results There were 20 positive and 16 negative causal effects between genetic liability in the gut microbiota and dementia. Also, there were five positive and four negative causal effects between cytokines and dementias. Cytokines did not act as mediating factors. Conclusions Gut microbiota and cytokines were causally associated with five types of dementia, and cytokines seemed not to be the mediating factors in the pathway from gut microbiota to dementia.https://doi.org/10.1186/s12974-023-02999-0Gut microbiotaDementiaCytokinesMendelian randomization |
| spellingShingle | Dong Ji Wen-Zhu Chen Lei Zhang Zhi-Hua Zhang Li-Jian Chen Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study Journal of Neuroinflammation Gut microbiota Dementia Cytokines Mendelian randomization |
| title | Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study |
| title_full | Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study |
| title_fullStr | Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study |
| title_full_unstemmed | Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study |
| title_short | Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study |
| title_sort | gut microbiota circulating cytokines and dementia a mendelian randomization study |
| topic | Gut microbiota Dementia Cytokines Mendelian randomization |
| url | https://doi.org/10.1186/s12974-023-02999-0 |
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