Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer
Abstract Objective To investigate the diagnostic value of diffusion kurtosis magnetic resonance imaging (DKI) and conventional diffusion-weighted imaging (DWI) for evaluating the response to first-line chemotherapy in unresectable pancreatic cancer. Materials and methods We retrospectively analyzed...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Cancer Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40644-024-00674-y |
| _version_ | 1827326416097640448 |
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| author | Zehua Zhang Yuqin Zhang Feixiang Hu Tiansong Xie Wei Liu Huijing Xiang Xiangxiang Li Lei Chen Zhengrong Zhou |
| author_facet | Zehua Zhang Yuqin Zhang Feixiang Hu Tiansong Xie Wei Liu Huijing Xiang Xiangxiang Li Lei Chen Zhengrong Zhou |
| author_sort | Zehua Zhang |
| collection | DOAJ |
| description | Abstract Objective To investigate the diagnostic value of diffusion kurtosis magnetic resonance imaging (DKI) and conventional diffusion-weighted imaging (DWI) for evaluating the response to first-line chemotherapy in unresectable pancreatic cancer. Materials and methods We retrospectively analyzed 21 patients with clinically and pathologically confirmed unresected pancreatic cancer who received palliative chemotherapy. Three-tesla MRI examinations containing DWI sequences with b values of 0, 100, 700, 1400, and 2100 s/mm2 were performed before and after chemotherapy. Parameters included the apparent diffusion coefficient (ADC), mean diffusion coefficient (MD), and mean diffusional kurtosis (MK). The performances of the DWI and DKI parameters in distinguishing the response to chemotherapy were evaluated by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Overall survival (OS) was calculated from the date of first treatment to the date of death or the latest follow-up date. Results The ADCchange and MDchange were significantly higher in the responding group (PR group) than in the nonresponding group (non-PR group) (ADCchange: 0.21 ± 0.05 vs. 0.11 ± 0.09, P = 0.02; MDchange: 0.37 ± 0.24 vs. 0.10 ± 0.12, P = 0.002). No statistical significance was shown when comparing ADCpre, ADCpost, MKpre, MKpost, MKchange, MDpre, and MDpost between the PR and non-PR groups. The ROC curve analysis indicated that MDchange (AUC = 0.898, cutoff value = 0.7143) performed better than ADCchange (AUC = 0.806, cutoff value = 0.1369) in predicting the response to chemotherapy. Conclusion The ADCchange and MDchange demonstrated strong potential for evaluating the response to chemotherapy in unresectable pancreatic cancer. The MDchange showed higher specificity in the classification of PR and non-PR than the ADCchange. Other parameters, including ADCpre, ADCpost, MKpre, MKpost, MKchange, MDpre, and MDpost, are not suitable for response evaluation. The combined model SUMchange demonstrated superior performance compared to the individual DWI and DKI models. Further experiments are needed to evaluate the potential of DWI and DKI parameters in predicting the prognosis of patients with unresectable pancreatic cancer. |
| first_indexed | 2024-03-07T14:44:10Z |
| format | Article |
| id | doaj.art-efa77f4dec4b4dab8c1f5587433f5c29 |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-03-07T14:44:10Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-efa77f4dec4b4dab8c1f5587433f5c292024-03-05T20:08:16ZengBMCCancer Imaging1470-73302024-02-012411910.1186/s40644-024-00674-yValue of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancerZehua Zhang0Yuqin Zhang1Feixiang Hu2Tiansong Xie3Wei Liu4Huijing Xiang5Xiangxiang Li6Lei Chen7Zhengrong Zhou8Department of Radiology, Minhang Branch, Fudan University Shanghai Cancer CenterDepartment of Colorectal Surgery, Minhang Branch, Fudan University Shanghai Cancer CenterDepartment of Radiology, Fudan University Shanghai Cancer CenterDepartment of Radiology, Fudan University Shanghai Cancer CenterDepartment of Radiology, Fudan University Shanghai Cancer CenterDepartment of Radiology, Minhang Branch, Fudan University Shanghai Cancer CenterNursing department, Minhang Branch, Fudan University Shanghai Cancer CenterDepartment of Radiology, Minhang Branch, Fudan University Shanghai Cancer CenterDepartment of Radiology, Minhang Branch, Fudan University Shanghai Cancer CenterAbstract Objective To investigate the diagnostic value of diffusion kurtosis magnetic resonance imaging (DKI) and conventional diffusion-weighted imaging (DWI) for evaluating the response to first-line chemotherapy in unresectable pancreatic cancer. Materials and methods We retrospectively analyzed 21 patients with clinically and pathologically confirmed unresected pancreatic cancer who received palliative chemotherapy. Three-tesla MRI examinations containing DWI sequences with b values of 0, 100, 700, 1400, and 2100 s/mm2 were performed before and after chemotherapy. Parameters included the apparent diffusion coefficient (ADC), mean diffusion coefficient (MD), and mean diffusional kurtosis (MK). The performances of the DWI and DKI parameters in distinguishing the response to chemotherapy were evaluated by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Overall survival (OS) was calculated from the date of first treatment to the date of death or the latest follow-up date. Results The ADCchange and MDchange were significantly higher in the responding group (PR group) than in the nonresponding group (non-PR group) (ADCchange: 0.21 ± 0.05 vs. 0.11 ± 0.09, P = 0.02; MDchange: 0.37 ± 0.24 vs. 0.10 ± 0.12, P = 0.002). No statistical significance was shown when comparing ADCpre, ADCpost, MKpre, MKpost, MKchange, MDpre, and MDpost between the PR and non-PR groups. The ROC curve analysis indicated that MDchange (AUC = 0.898, cutoff value = 0.7143) performed better than ADCchange (AUC = 0.806, cutoff value = 0.1369) in predicting the response to chemotherapy. Conclusion The ADCchange and MDchange demonstrated strong potential for evaluating the response to chemotherapy in unresectable pancreatic cancer. The MDchange showed higher specificity in the classification of PR and non-PR than the ADCchange. Other parameters, including ADCpre, ADCpost, MKpre, MKpost, MKchange, MDpre, and MDpost, are not suitable for response evaluation. The combined model SUMchange demonstrated superior performance compared to the individual DWI and DKI models. Further experiments are needed to evaluate the potential of DWI and DKI parameters in predicting the prognosis of patients with unresectable pancreatic cancer.https://doi.org/10.1186/s40644-024-00674-yDiffusion kurtosis imagingApparent diffusion coefficientUnresectable pancreatic cancerFirst-line chemotherapy |
| spellingShingle | Zehua Zhang Yuqin Zhang Feixiang Hu Tiansong Xie Wei Liu Huijing Xiang Xiangxiang Li Lei Chen Zhengrong Zhou Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer Cancer Imaging Diffusion kurtosis imaging Apparent diffusion coefficient Unresectable pancreatic cancer First-line chemotherapy |
| title | Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer |
| title_full | Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer |
| title_fullStr | Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer |
| title_full_unstemmed | Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer |
| title_short | Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer |
| title_sort | value of diffusion kurtosis mr imaging and conventional diffusion weighed imaging for evaluating response to first line chemotherapy in unresectable pancreatic cancer |
| topic | Diffusion kurtosis imaging Apparent diffusion coefficient Unresectable pancreatic cancer First-line chemotherapy |
| url | https://doi.org/10.1186/s40644-024-00674-y |
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