Salmonella typhimurium TA100 and TA1535 and E. coli WP2 uvrA are highly sensitive to detect the mutagenicity of short Alkyl-N-Nitrosamines in the Bacterial Reverse Mutation Test

Salmonella typhimurium TA100 and TA1535 and E. coli WP2 uvrA are highly sensitive to detect the mutagenicity of short Alkyl-N-Nitrosamines in the Bacterial Reverse Mutation Test

Humans are exposed to low levels of N-nitrosamines via different sources. N-Nitrosamines have recently been detected as impurities in various marketed drugs and they are known mutagenic carcinogens belonging to the cohort of concern as referred to in the ICH M7 guideline. Despite their well-known mu...

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Bibliographic Details
Main Authors: Frank Bringezu, Stephanie Simon
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Toxicology Reports
Subjects:
N-Nitrosamines
Bacterial reverse mutation assay
Rat liver S9
TA100
TA1535
WP2 uvrA
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750022000191

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http://www.sciencedirect.com/science/article/pii/S2214750022000191

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