A systematic review and meta-analysis of acupuncture in Parkinson's disease with dysphagia
ObjectiveThe systematic review and meta-analysis aimed to comprehensively evaluate acupuncture's efficacy and safety in treating dysphagia in Parkinson's disease (PD).MethodsWe searched PubMed, Cochrane Library, Embase, Web of Science, China Knowledge Infrastructure (CNKI), China Science J...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1099012/full |
| _version_ | 1827940762851999744 |
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| author | Jing Wu Yi Wang Xueyan Wang Yujia Xie Weihong Li |
| author_facet | Jing Wu Yi Wang Xueyan Wang Yujia Xie Weihong Li |
| author_sort | Jing Wu |
| collection | DOAJ |
| description | ObjectiveThe systematic review and meta-analysis aimed to comprehensively evaluate acupuncture's efficacy and safety in treating dysphagia in Parkinson's disease (PD).MethodsWe searched PubMed, Cochrane Library, Embase, Web of Science, China Knowledge Infrastructure (CNKI), China Science Journal Database (VIP), Wan-fang Database, and the China Biomedical Literature Service System (CBM) for randomized controlled trials (RCTs) comparing the efficacy of acupuncture alone or in combination with control treatment in improving dysphagia by October 2022. The degree of dysphagia was the primary outcome indicator, with secondary outcomes including serum albumin (ALB) and hemoglobin (Hb) levels, the incidence of pneumonia, and adverse events. Two investigators independently extracted information according to the inclusion and exclusion criteria. Data synthesis was calculated by RevMan (V.5.4.1) software.ResultsThis study included ten randomized controlled trials with 724 patients. Most RCTs have a high or uncertain risk of bias due to the lack of a blinded design. Meta-analysis showed that acupuncture combined with control treatment was superior to control treatment alone in improving Videofluoroscopic Swallowing Study (VFSS) scores (MD: 1.48; 95% CI: 1.16, 1.81; P < 0.00001) and reducing Standardized Swallowing Assessment (SSA) scores (MD: −3.08; 95% CI: −4.01, −2.15; P < 0.00001). Acupuncture combined with control therapy has a more significant benefit in improving the clinical efficiency of dysphagia in PD (RR: 1.40; 95%CI: 1.25, 1.58; P < 0.00001). Compared to the control group without acupuncture, acupuncture improved the nutritional status of patients and increased their serum ALB (MD: 3.38, 95%CI: 1.83, 4.92, P < 0.00001) and Hb levels (MD: 7.66; 95%CI: 5.57, 9.75; P < 0.00001). Three RCTs reported that the rate of pulmonary infections in the acupuncture group was lower than without acupuncture intervention (RR: 0.29, 95% CI: 0.14, 0.63; P = 0.001).ConclusionAcupuncture could be recommended as an adjunctive treatment for dysphagia in PD. However, due to the high risk of bias in the included studies, more high-quality evidence is needed to confirm the efficacy and safety of acupuncture for dysphagia in PD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022370221. |
| first_indexed | 2024-03-13T09:15:41Z |
| format | Article |
| id | doaj.art-efa9dcc395284938b0e7f9951acc34cc |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T09:15:41Z |
| publishDate | 2023-05-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-efa9dcc395284938b0e7f9951acc34cc2023-05-26T10:34:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-05-011410.3389/fneur.2023.10990121099012A systematic review and meta-analysis of acupuncture in Parkinson's disease with dysphagiaJing Wu0Yi Wang1Xueyan Wang2Yujia Xie3Weihong Li4Basic Medical School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaBasic Medical School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaClinical Medical School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaBasic Medical School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaBasic Medical School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaObjectiveThe systematic review and meta-analysis aimed to comprehensively evaluate acupuncture's efficacy and safety in treating dysphagia in Parkinson's disease (PD).MethodsWe searched PubMed, Cochrane Library, Embase, Web of Science, China Knowledge Infrastructure (CNKI), China Science Journal Database (VIP), Wan-fang Database, and the China Biomedical Literature Service System (CBM) for randomized controlled trials (RCTs) comparing the efficacy of acupuncture alone or in combination with control treatment in improving dysphagia by October 2022. The degree of dysphagia was the primary outcome indicator, with secondary outcomes including serum albumin (ALB) and hemoglobin (Hb) levels, the incidence of pneumonia, and adverse events. Two investigators independently extracted information according to the inclusion and exclusion criteria. Data synthesis was calculated by RevMan (V.5.4.1) software.ResultsThis study included ten randomized controlled trials with 724 patients. Most RCTs have a high or uncertain risk of bias due to the lack of a blinded design. Meta-analysis showed that acupuncture combined with control treatment was superior to control treatment alone in improving Videofluoroscopic Swallowing Study (VFSS) scores (MD: 1.48; 95% CI: 1.16, 1.81; P < 0.00001) and reducing Standardized Swallowing Assessment (SSA) scores (MD: −3.08; 95% CI: −4.01, −2.15; P < 0.00001). Acupuncture combined with control therapy has a more significant benefit in improving the clinical efficiency of dysphagia in PD (RR: 1.40; 95%CI: 1.25, 1.58; P < 0.00001). Compared to the control group without acupuncture, acupuncture improved the nutritional status of patients and increased their serum ALB (MD: 3.38, 95%CI: 1.83, 4.92, P < 0.00001) and Hb levels (MD: 7.66; 95%CI: 5.57, 9.75; P < 0.00001). Three RCTs reported that the rate of pulmonary infections in the acupuncture group was lower than without acupuncture intervention (RR: 0.29, 95% CI: 0.14, 0.63; P = 0.001).ConclusionAcupuncture could be recommended as an adjunctive treatment for dysphagia in PD. However, due to the high risk of bias in the included studies, more high-quality evidence is needed to confirm the efficacy and safety of acupuncture for dysphagia in PD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022370221.https://www.frontiersin.org/articles/10.3389/fneur.2023.1099012/fullacupunctureParkinson's diseasedysphagiasystematic reviewmeta-analysis |
| spellingShingle | Jing Wu Yi Wang Xueyan Wang Yujia Xie Weihong Li A systematic review and meta-analysis of acupuncture in Parkinson's disease with dysphagia Frontiers in Neurology acupuncture Parkinson's disease dysphagia systematic review meta-analysis |
| title | A systematic review and meta-analysis of acupuncture in Parkinson's disease with dysphagia |
| title_full | A systematic review and meta-analysis of acupuncture in Parkinson's disease with dysphagia |
| title_fullStr | A systematic review and meta-analysis of acupuncture in Parkinson's disease with dysphagia |
| title_full_unstemmed | A systematic review and meta-analysis of acupuncture in Parkinson's disease with dysphagia |
| title_short | A systematic review and meta-analysis of acupuncture in Parkinson's disease with dysphagia |
| title_sort | systematic review and meta analysis of acupuncture in parkinson s disease with dysphagia |
| topic | acupuncture Parkinson's disease dysphagia systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1099012/full |
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