The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control
Aims: To study the metabolic effects of fructose, glucose and saccharose in a moderate dose by analyzing changes of blood indicators, pancreas inflammation, liver fat accumulation and intestinal microbiota in normal Sprague-Dawley (SD) rats. Subjects and methods: Six-week-old rats were assigned to f...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Swedish Nutrition Foundation
2021-05-01
|
| Series: | Food & Nutrition Research |
| Subjects: | |
| Online Access: | https://foodandnutritionresearch.net/index.php/fnr/article/view/5589/13351 |
| _version_ | 1819003784172404736 |
|---|---|
| author | Ge Song Wentao Qi Yong Wang Shaojie Pang Yong Li |
| author_facet | Ge Song Wentao Qi Yong Wang Shaojie Pang Yong Li |
| author_sort | Ge Song |
| collection | DOAJ |
| description | Aims: To study the metabolic effects of fructose, glucose and saccharose in a moderate dose by analyzing changes of blood indicators, pancreas inflammation, liver fat accumulation and intestinal microbiota in normal Sprague-Dawley (SD) rats. Subjects and methods: Six-week-old rats were assigned to four groups (n = 10), which were gavaged with normalsaline (Con), glucose dissolved in normal saline (Glu), saccharose-glucose dissolved in normal saline (Sac), and fructose dissolved in normal saline (Fru) for 20 weeks. Results: No significant differences in body weight and blood parameters including total cholesterol (TC), total triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), lipase (LPS) and free fatty acid (FFA) among the Con, Glu, Sac and the Fru group. The fructose can significantly (P < 0.05) decrease fasting and postprandial blood glucose increase compared to glucose, and the risk of pancreas inflammation and liver fat accumulation induced by fructose is lower than glucose in rats. We found there were no significant differences in intestinal microbial diversity. At the family level, rats in the Glu group had a relatively higher abundance of Peptostreptococcaceae and rats in the Fru group had a relatively higher abundance of Bacteroidaceae. Moreover, the proportions of Peptostreptococcaceae romboutsia and Staphylococcus lentus in the Glu group were significantly higher than in the Fru group, while the proportions of Lachnospira; Lachnospiraceae blautia, Bacteroides and Cellulosilyticus in the Fru group were significantly higher than in the Glu group. The concentration of isobutyric acid was relatively lower in all the sugar treated groups than in the Con. A significant decrease in isobutyric acid was found on comparing the Fru group to the Con group (P < 0.05). Conclusion: Fructose, glucose and sucrose made no significant changes on rats in body weight, blood indicators, organ index and bacterial diversity. Moreover, fructose can potentially attenuate fasting and postprandial blood-glucose increase, pancreas inflammation and liver-fat accumulation when compared to glucose in mild doses. The relative abundance of six kinds of bacterial genera was found significantly different between rats fed on fructose and glucose. |
| first_indexed | 2024-12-20T23:26:30Z |
| format | Article |
| id | doaj.art-efaa170a258b4625b9c754e98f64363a |
| institution | Directory Open Access Journal |
| issn | 1654-661X |
| language | English |
| last_indexed | 2024-12-20T23:26:30Z |
| publishDate | 2021-05-01 |
| publisher | Swedish Nutrition Foundation |
| record_format | Article |
| series | Food & Nutrition Research |
| spelling | doaj.art-efaa170a258b4625b9c754e98f64363a2022-12-21T19:23:24ZengSwedish Nutrition FoundationFood & Nutrition Research1654-661X2021-05-016511410.29219/fnr.v65.5589FNR-65-5589The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as controlGe Song0Wentao Qi1Yong Wang2Shaojie Pang3Yong Li4Institute of Grain Quality and Nutrition Research, Academy of National Food and Strategic Reserves Administration, Beijing, People’s Republic of ChinaInstitute of Grain Quality and Nutrition Research, Academy of National Food and Strategic Reserves Administration, Beijing, People’s Republic of ChinaInstitute of Grain Quality and Nutrition Research, Academy of National Food and Strategic Reserves Administration, Beijing, People’s Republic of ChinaInstitute of Grain Quality and Nutrition Research, Academy of National Food and Strategic Reserves Administration, Beijing, People’s Republic of ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, People’s Republic of ChinaAims: To study the metabolic effects of fructose, glucose and saccharose in a moderate dose by analyzing changes of blood indicators, pancreas inflammation, liver fat accumulation and intestinal microbiota in normal Sprague-Dawley (SD) rats. Subjects and methods: Six-week-old rats were assigned to four groups (n = 10), which were gavaged with normalsaline (Con), glucose dissolved in normal saline (Glu), saccharose-glucose dissolved in normal saline (Sac), and fructose dissolved in normal saline (Fru) for 20 weeks. Results: No significant differences in body weight and blood parameters including total cholesterol (TC), total triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), lipase (LPS) and free fatty acid (FFA) among the Con, Glu, Sac and the Fru group. The fructose can significantly (P < 0.05) decrease fasting and postprandial blood glucose increase compared to glucose, and the risk of pancreas inflammation and liver fat accumulation induced by fructose is lower than glucose in rats. We found there were no significant differences in intestinal microbial diversity. At the family level, rats in the Glu group had a relatively higher abundance of Peptostreptococcaceae and rats in the Fru group had a relatively higher abundance of Bacteroidaceae. Moreover, the proportions of Peptostreptococcaceae romboutsia and Staphylococcus lentus in the Glu group were significantly higher than in the Fru group, while the proportions of Lachnospira; Lachnospiraceae blautia, Bacteroides and Cellulosilyticus in the Fru group were significantly higher than in the Glu group. The concentration of isobutyric acid was relatively lower in all the sugar treated groups than in the Con. A significant decrease in isobutyric acid was found on comparing the Fru group to the Con group (P < 0.05). Conclusion: Fructose, glucose and sucrose made no significant changes on rats in body weight, blood indicators, organ index and bacterial diversity. Moreover, fructose can potentially attenuate fasting and postprandial blood-glucose increase, pancreas inflammation and liver-fat accumulation when compared to glucose in mild doses. The relative abundance of six kinds of bacterial genera was found significantly different between rats fed on fructose and glucose.https://foodandnutritionresearch.net/index.php/fnr/article/view/5589/13351fructoseglucosesaccharosemild dosemetabolic effectintestinal micro biota |
| spellingShingle | Ge Song Wentao Qi Yong Wang Shaojie Pang Yong Li The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control Food & Nutrition Research fructose glucose saccharose mild dose metabolic effect intestinal micro biota |
| title | The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control |
| title_full | The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control |
| title_fullStr | The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control |
| title_full_unstemmed | The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control |
| title_short | The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control |
| title_sort | metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control |
| topic | fructose glucose saccharose mild dose metabolic effect intestinal micro biota |
| url | https://foodandnutritionresearch.net/index.php/fnr/article/view/5589/13351 |
| work_keys_str_mv | AT gesong themetaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol AT wentaoqi themetaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol AT yongwang themetaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol AT shaojiepang themetaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol AT yongli themetaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol AT gesong metaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol AT wentaoqi metaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol AT yongwang metaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol AT shaojiepang metaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol AT yongli metaboliceffectoffructoseonnormalratsinamilddosewithglucoseandsaccharoseascontrol |