Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker
The most common cause of heart failure in the canine population is myxomatous mitral valve disease, sometimes complicated by chronic kidney disease. Many studies have been done on the use of symmetric dimethylarginine as biomarker of renal impairment in dogs affected by chronic kidney disease, few s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Tripoli University
2018-08-01
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| Series: | Open Veterinary Journal |
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| Online Access: | https://www.openveterinaryjournal.com/OVJ-2018-02-047%20A.%20Savarese%20et%20al.pdf |
| _version_ | 1819134882467545088 |
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| author | Alice Savarese Monica Probo Chiara Locatelli Sergio Aurelio Zanzani Alessia Libera Gazzonis Melissa Papa Paola Giuseppina Brambilla |
| author_facet | Alice Savarese Monica Probo Chiara Locatelli Sergio Aurelio Zanzani Alessia Libera Gazzonis Melissa Papa Paola Giuseppina Brambilla |
| author_sort | Alice Savarese |
| collection | DOAJ |
| description | The most common cause of heart failure in the canine population is myxomatous mitral valve disease, sometimes complicated by chronic kidney disease. Many studies have been done on the use of symmetric dimethylarginine as biomarker of renal impairment in dogs affected by chronic kidney disease, few studies have examined his reliability as biomarker in dogs affected by heart diseases. Aim of this study was to evaluate symmetric dimethylarginine in dogs affected by mitral valve disease in order to assess his reliability in heart diseases. This was a retrospective case-control study on a clinical population of dogs affected by mitral valve disease (cases) vs healthy dogs (controls). Both groups underwent a complete physical evaluation, echocardiographic examination, complete blood count, biochemical panel, including serum creatinine and urea and urine analysis with protein-to-creatinine ratio. Serum was frozen and sent to IDEXX laboratories for symmetric dimethylarginine determination. General linear model was applied to data. A total number of 24 cases and 7 controls were included. Symmetric dimethylarginine value was in the reference value in the 75% (n=18) of cases, and in the 43% (n=3) of controls. Once set symmetric dimethylarginine as dependent variable, no statistical significant differences were found for each variable considered (breed, age, sex, weight, class of cardiomyopathy, presence/absence of valvular disease, presence/absence of congestive heart failure, pharmacological therapy, creatinine and urea concentration). Blood concentration of SDMA resulted not influenced by the variables mentioned above, so it could be considered a reliable marker of early renal impairment in dogs affected by mitral valve disease. |
| first_indexed | 2024-12-22T10:10:15Z |
| format | Article |
| id | doaj.art-efac5d3842c74aeb942d9895b9f48cae |
| institution | Directory Open Access Journal |
| issn | 2218-6050 2218-6050 |
| language | English |
| last_indexed | 2024-12-22T10:10:15Z |
| publishDate | 2018-08-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-efac5d3842c74aeb942d9895b9f48cae2022-12-21T18:29:54ZengTripoli UniversityOpen Veterinary Journal2218-60502218-60502018-08-0183318324http://dx.doi.org/10.4314/ovj.v8i3.11Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarkerAlice SavareseMonica ProboChiara LocatelliSergio Aurelio ZanzaniAlessia Libera GazzonisMelissa PapaPaola Giuseppina BrambillaThe most common cause of heart failure in the canine population is myxomatous mitral valve disease, sometimes complicated by chronic kidney disease. Many studies have been done on the use of symmetric dimethylarginine as biomarker of renal impairment in dogs affected by chronic kidney disease, few studies have examined his reliability as biomarker in dogs affected by heart diseases. Aim of this study was to evaluate symmetric dimethylarginine in dogs affected by mitral valve disease in order to assess his reliability in heart diseases. This was a retrospective case-control study on a clinical population of dogs affected by mitral valve disease (cases) vs healthy dogs (controls). Both groups underwent a complete physical evaluation, echocardiographic examination, complete blood count, biochemical panel, including serum creatinine and urea and urine analysis with protein-to-creatinine ratio. Serum was frozen and sent to IDEXX laboratories for symmetric dimethylarginine determination. General linear model was applied to data. A total number of 24 cases and 7 controls were included. Symmetric dimethylarginine value was in the reference value in the 75% (n=18) of cases, and in the 43% (n=3) of controls. Once set symmetric dimethylarginine as dependent variable, no statistical significant differences were found for each variable considered (breed, age, sex, weight, class of cardiomyopathy, presence/absence of valvular disease, presence/absence of congestive heart failure, pharmacological therapy, creatinine and urea concentration). Blood concentration of SDMA resulted not influenced by the variables mentioned above, so it could be considered a reliable marker of early renal impairment in dogs affected by mitral valve disease.https://www.openveterinaryjournal.com/OVJ-2018-02-047%20A.%20Savarese%20et%20al.pdfBiomarkerCardiovascular-renal disorderDogMyxomatous mitral valve diseaseSymmetric dimethylarginine |
| spellingShingle | Alice Savarese Monica Probo Chiara Locatelli Sergio Aurelio Zanzani Alessia Libera Gazzonis Melissa Papa Paola Giuseppina Brambilla Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker Open Veterinary Journal Biomarker Cardiovascular-renal disorder Dog Myxomatous mitral valve disease Symmetric dimethylarginine |
| title | Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker |
| title_full | Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker |
| title_fullStr | Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker |
| title_full_unstemmed | Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker |
| title_short | Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker |
| title_sort | reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker |
| topic | Biomarker Cardiovascular-renal disorder Dog Myxomatous mitral valve disease Symmetric dimethylarginine |
| url | https://www.openveterinaryjournal.com/OVJ-2018-02-047%20A.%20Savarese%20et%20al.pdf |
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