Study on diurnal variation in TSH and freeT4 levels of healthy adults
<p class="Default"><span>Thyroid stimulating hormone (TSH) secretion shows a circadian rhythm, affecting free thyroxine (fT4) secretion in the same manner. Samples are collected randomly throughout the day for serum TSH & fT4 measurement in current practice. This may af...
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| Format: | Article |
| Language: | English |
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Sri Lanka College of Endocrinologists
2018-04-01
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| Series: | Sri Lanka Journal of Diabetes Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | https://sjdem.sljol.info/articles/7346 |
| _version_ | 1818883349871067136 |
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| author | Y.S.H. Liyanage I.D. Siriwardhana M. Dissanayake B.K.P.T. Dayanath |
| author_facet | Y.S.H. Liyanage I.D. Siriwardhana M. Dissanayake B.K.P.T. Dayanath |
| author_sort | Y.S.H. Liyanage |
| collection | DOAJ |
| description | <p class="Default"><span>Thyroid stimulating hormone (TSH) secretion shows a circadian rhythm, affecting free thyroxine (fT4) secretion in the same manner. Samples are collected randomly throughout the day for serum TSH & fT4 measurement in current practice. This may affect interpretation of results if the follow up samples are collected at different times of the day from the same individual. We aimed to assess the diurnal variation in serum TSH and fT4 levels in healthy adults. Healthy adult volunteers with Sinhalese ethnicity aged 21 -50 years were selected for the study. Subjects with thyroid or any other disease, on medications including oral contraceptives and postmenopausal women were excluded. Two blood samples were drawn from each subject at 8-9 am and 3-4 pm on the same day. TSH and fT4 were measured using VITROS ECi Immunodiagnostic system. Paired T test was used to assess whether there was a statistically significant diurnal variation in hormone values. Data were analyzed using IBM SPSS Statistics Version 20 and Microsoft Excel 2013. A total number of 36 subjects with an equal number of males & females participated in the study. There was no variation in hormone levels due to age or gender. Log transformed TSH and fT4, showed a statistically significant difference for both TSH (p=0.013) and freeT4 (p<0.001) values in the morning and afternoon. Standardization of sample collection time may be important for TSH and fT4 hormone assays as this study revealed a statistically significant diurnal variation for both hormones. However further studies are needed in patients withthyroid diseases and individuals of other age groups as well to ascertain the clinical significance.</span></p><p class="Default"> </p> |
| first_indexed | 2024-12-19T15:32:15Z |
| format | Article |
| id | doaj.art-efac83350cbc42599be95078eeca33e8 |
| institution | Directory Open Access Journal |
| issn | 2012-998X |
| language | English |
| last_indexed | 2024-12-19T15:32:15Z |
| publishDate | 2018-04-01 |
| publisher | Sri Lanka College of Endocrinologists |
| record_format | Article |
| series | Sri Lanka Journal of Diabetes Endocrinology and Metabolism |
| spelling | doaj.art-efac83350cbc42599be95078eeca33e82022-12-21T20:15:42ZengSri Lanka College of EndocrinologistsSri Lanka Journal of Diabetes Endocrinology and Metabolism2012-998X2018-04-018181610.4038/sjdem.v8i1.73465586Study on diurnal variation in TSH and freeT4 levels of healthy adultsY.S.H. Liyanage0I.D. Siriwardhana1M. Dissanayake2B.K.P.T. Dayanath3Faculty of Medicine, University of Ruhuna, GalleFaculty of Medicine, University of Ruhuna, GalleTeaching Hospital Karapitiya GalleNorth Colombo Teaching Hospital, Ragama<p class="Default"><span>Thyroid stimulating hormone (TSH) secretion shows a circadian rhythm, affecting free thyroxine (fT4) secretion in the same manner. Samples are collected randomly throughout the day for serum TSH & fT4 measurement in current practice. This may affect interpretation of results if the follow up samples are collected at different times of the day from the same individual. We aimed to assess the diurnal variation in serum TSH and fT4 levels in healthy adults. Healthy adult volunteers with Sinhalese ethnicity aged 21 -50 years were selected for the study. Subjects with thyroid or any other disease, on medications including oral contraceptives and postmenopausal women were excluded. Two blood samples were drawn from each subject at 8-9 am and 3-4 pm on the same day. TSH and fT4 were measured using VITROS ECi Immunodiagnostic system. Paired T test was used to assess whether there was a statistically significant diurnal variation in hormone values. Data were analyzed using IBM SPSS Statistics Version 20 and Microsoft Excel 2013. A total number of 36 subjects with an equal number of males & females participated in the study. There was no variation in hormone levels due to age or gender. Log transformed TSH and fT4, showed a statistically significant difference for both TSH (p=0.013) and freeT4 (p<0.001) values in the morning and afternoon. Standardization of sample collection time may be important for TSH and fT4 hormone assays as this study revealed a statistically significant diurnal variation for both hormones. However further studies are needed in patients withthyroid diseases and individuals of other age groups as well to ascertain the clinical significance.</span></p><p class="Default"> </p>https://sjdem.sljol.info/articles/7346thyroid stimulating hormone (tsh)free thyroxine (ft4)diurnal variationhormone assays |
| spellingShingle | Y.S.H. Liyanage I.D. Siriwardhana M. Dissanayake B.K.P.T. Dayanath Study on diurnal variation in TSH and freeT4 levels of healthy adults Sri Lanka Journal of Diabetes Endocrinology and Metabolism thyroid stimulating hormone (tsh) free thyroxine (ft4) diurnal variation hormone assays |
| title | Study on diurnal variation in TSH and freeT4 levels of healthy adults |
| title_full | Study on diurnal variation in TSH and freeT4 levels of healthy adults |
| title_fullStr | Study on diurnal variation in TSH and freeT4 levels of healthy adults |
| title_full_unstemmed | Study on diurnal variation in TSH and freeT4 levels of healthy adults |
| title_short | Study on diurnal variation in TSH and freeT4 levels of healthy adults |
| title_sort | study on diurnal variation in tsh and freet4 levels of healthy adults |
| topic | thyroid stimulating hormone (tsh) free thyroxine (ft4) diurnal variation hormone assays |
| url | https://sjdem.sljol.info/articles/7346 |
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