Stratification of patients with unclassified pain in the FabryScan database
Julia Forstenpointner,* Paul Moeller,* Manon Sendel, Maren Reimer, Philipp Hüllemann, Ralf BaronDivision of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Kiel 24105, Germany*These authors contributed equally to this workPurpose: Fab...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-07-01
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| Series: | Journal of Pain Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/stratification-of-patients-with-unclassified-pain-in-the-fabryscan-dat-peer-reviewed-article-JPR |
| _version_ | 1818255042928443392 |
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| author | Forstenpointner J Moeller P Sendel M Reimer M Hüllemann P Baron R |
| author_facet | Forstenpointner J Moeller P Sendel M Reimer M Hüllemann P Baron R |
| author_sort | Forstenpointner J |
| collection | DOAJ |
| description | Julia Forstenpointner,* Paul Moeller,* Manon Sendel, Maren Reimer, Philipp Hüllemann, Ralf BaronDivision of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Kiel 24105, Germany*These authors contributed equally to this workPurpose: Fabry disease belongs to lysosomal storage disorders and can be successfully treated today. On the contrary, the correct diagnostic classification of its symptoms can be challenging and most patients suffer from pain for years, until they are diagnosed correctly. The aim of this project was to characterize patients with unclassified extremity pain and to present a simple algorithm for a retrospective stratification approach.Patients and methods: The FabryScan includes a bedside-test and a questionnaire, consisting of 10 symptom-orientated and anamnestic questions. For the stratification of patients according to the likelihood for Fabry disease two different approaches were conducted. First, a prospective subgrouping based on the previously invented FabryScan evaluation system was conducted. The second retrospective approach consisted of a factor analysis and a subsequent two-way cluster analysis. Further on, 4 patients diagnosed with Fabry disease were stratified according to both approaches.Results: In total, 183 completed datasets were included in the statistical analysis. The first approach prospectively classified patients into 3 subgroups (n=40 [likely], n=96 [possible], n=47 [unlikely]) according to the FabryScan evaluation system. The second approach retrospectively stratified patients into 3 subgroups (n=47 [cluster 1], n=95 [cluster 2], n=41 [cluster 3]). Finally, the Fabry patients were sorted to the subgroups, indicative for the highest possibility of Fabry disease in both stratification approaches A and B.Conclusion: Both stratification approaches sorted patients with confirmed Fabry disease to the subgroups, indicative for the highest likelihood for Fabry. These results indicate validity of the initially selected FabryScan outcome parameters.Keywords: extremity pain, Fabry disease, classification, neuropathic pain |
| first_indexed | 2024-12-12T17:05:35Z |
| format | Article |
| id | doaj.art-efaccf607f354ad98a9a6005d43bb1d3 |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-12T17:05:35Z |
| publishDate | 2019-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-efaccf607f354ad98a9a6005d43bb1d32022-12-22T00:18:01ZengDove Medical PressJournal of Pain Research1178-70902019-07-01Volume 122223223047316Stratification of patients with unclassified pain in the FabryScan databaseForstenpointner JMoeller PSendel MReimer MHüllemann PBaron RJulia Forstenpointner,* Paul Moeller,* Manon Sendel, Maren Reimer, Philipp Hüllemann, Ralf BaronDivision of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Kiel 24105, Germany*These authors contributed equally to this workPurpose: Fabry disease belongs to lysosomal storage disorders and can be successfully treated today. On the contrary, the correct diagnostic classification of its symptoms can be challenging and most patients suffer from pain for years, until they are diagnosed correctly. The aim of this project was to characterize patients with unclassified extremity pain and to present a simple algorithm for a retrospective stratification approach.Patients and methods: The FabryScan includes a bedside-test and a questionnaire, consisting of 10 symptom-orientated and anamnestic questions. For the stratification of patients according to the likelihood for Fabry disease two different approaches were conducted. First, a prospective subgrouping based on the previously invented FabryScan evaluation system was conducted. The second retrospective approach consisted of a factor analysis and a subsequent two-way cluster analysis. Further on, 4 patients diagnosed with Fabry disease were stratified according to both approaches.Results: In total, 183 completed datasets were included in the statistical analysis. The first approach prospectively classified patients into 3 subgroups (n=40 [likely], n=96 [possible], n=47 [unlikely]) according to the FabryScan evaluation system. The second approach retrospectively stratified patients into 3 subgroups (n=47 [cluster 1], n=95 [cluster 2], n=41 [cluster 3]). Finally, the Fabry patients were sorted to the subgroups, indicative for the highest possibility of Fabry disease in both stratification approaches A and B.Conclusion: Both stratification approaches sorted patients with confirmed Fabry disease to the subgroups, indicative for the highest likelihood for Fabry. These results indicate validity of the initially selected FabryScan outcome parameters.Keywords: extremity pain, Fabry disease, classification, neuropathic painhttps://www.dovepress.com/stratification-of-patients-with-unclassified-pain-in-the-fabryscan-dat-peer-reviewed-article-JPRextremity painFabry diseaseclassificationneuropathic pain |
| spellingShingle | Forstenpointner J Moeller P Sendel M Reimer M Hüllemann P Baron R Stratification of patients with unclassified pain in the FabryScan database Journal of Pain Research extremity pain Fabry disease classification neuropathic pain |
| title | Stratification of patients with unclassified pain in the FabryScan database |
| title_full | Stratification of patients with unclassified pain in the FabryScan database |
| title_fullStr | Stratification of patients with unclassified pain in the FabryScan database |
| title_full_unstemmed | Stratification of patients with unclassified pain in the FabryScan database |
| title_short | Stratification of patients with unclassified pain in the FabryScan database |
| title_sort | stratification of patients with unclassified pain in the fabryscan database |
| topic | extremity pain Fabry disease classification neuropathic pain |
| url | https://www.dovepress.com/stratification-of-patients-with-unclassified-pain-in-the-fabryscan-dat-peer-reviewed-article-JPR |
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