A new pma1 mutation identified in a chronologically long-lived fission yeast mutant
We isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1+ that encoded for an essential P-type proton ATPase. An Asp-138 to Asn mutation resulted in reduced Pma1 activity, concomitant with an increase in the chronological lifespan of this fission...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211546314000886 |
| _version_ | 1819203509305737216 |
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| author | Chikako Naito Hirokazu Ito Tomoko Oshiro Hokuto Ohtsuka Hiroshi Murakami Hirofumi Aiba |
| author_facet | Chikako Naito Hirokazu Ito Tomoko Oshiro Hokuto Ohtsuka Hiroshi Murakami Hirofumi Aiba |
| author_sort | Chikako Naito |
| collection | DOAJ |
| description | We isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1+ that encoded for an essential P-type proton ATPase. An Asp-138 to Asn mutation resulted in reduced Pma1 activity, concomitant with an increase in the chronological lifespan of this fission yeast. This study corroborates our previous report indicating Pma1 activity is crucial for the determination of life span of fission yeast, and offers information for better understanding of the enzyme, Pma1. |
| first_indexed | 2024-12-23T04:21:03Z |
| format | Article |
| id | doaj.art-efad2aea4be5403b8edd934639aa2c20 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-12-23T04:21:03Z |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-efad2aea4be5403b8edd934639aa2c202022-12-21T18:00:15ZengWileyFEBS Open Bio2211-54632014-01-014C82983310.1016/j.fob.2014.09.006A new pma1 mutation identified in a chronologically long-lived fission yeast mutantChikako Naito0Hirokazu Ito1Tomoko Oshiro2Hokuto Ohtsuka3Hiroshi Murakami4Hirofumi Aiba5Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, JapanLaboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, JapanLaboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, JapanLaboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, JapanDepartment of Biological Science, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, JapanLaboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, JapanWe isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1+ that encoded for an essential P-type proton ATPase. An Asp-138 to Asn mutation resulted in reduced Pma1 activity, concomitant with an increase in the chronological lifespan of this fission yeast. This study corroborates our previous report indicating Pma1 activity is crucial for the determination of life span of fission yeast, and offers information for better understanding of the enzyme, Pma1.http://www.sciencedirect.com/science/article/pii/S2211546314000886Chronological lifespanFission yeastPma1 |
| spellingShingle | Chikako Naito Hirokazu Ito Tomoko Oshiro Hokuto Ohtsuka Hiroshi Murakami Hirofumi Aiba A new pma1 mutation identified in a chronologically long-lived fission yeast mutant FEBS Open Bio Chronological lifespan Fission yeast Pma1 |
| title | A new pma1 mutation identified in a chronologically long-lived fission yeast mutant |
| title_full | A new pma1 mutation identified in a chronologically long-lived fission yeast mutant |
| title_fullStr | A new pma1 mutation identified in a chronologically long-lived fission yeast mutant |
| title_full_unstemmed | A new pma1 mutation identified in a chronologically long-lived fission yeast mutant |
| title_short | A new pma1 mutation identified in a chronologically long-lived fission yeast mutant |
| title_sort | new pma1 mutation identified in a chronologically long lived fission yeast mutant |
| topic | Chronological lifespan Fission yeast Pma1 |
| url | http://www.sciencedirect.com/science/article/pii/S2211546314000886 |
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