Brain Structural and Functional Dissociated Patterns in Degenerative Cervical Myelopathy: A Case-Controlled Retrospective Resting-State fMRI Study
BackgroundPrevious studies have shown the whole-brain global functional connectivity density (gFCD) and gray matter volume (GMV) alterations in patients with degenerative cervical myelopathy (DCM). However, no study aimed to investigate the associations between the spatial patterns of GMV and gFCD a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.895348/full |
| _version_ | 1828327918698233856 |
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| author | Yi Zhou Jiaqi Shi |
| author_facet | Yi Zhou Jiaqi Shi |
| author_sort | Yi Zhou |
| collection | DOAJ |
| description | BackgroundPrevious studies have shown the whole-brain global functional connectivity density (gFCD) and gray matter volume (GMV) alterations in patients with degenerative cervical myelopathy (DCM). However, no study aimed to investigate the associations between the spatial patterns of GMV and gFCD alterations in patients with DCM.MethodsStructural data and resting-state functional MRI data of 35 DCM patients and 35 matched healthy controls were collected to assess their gFCD and GMV and investigate gFCD and GMV alterations in patients with DCM and their spatial pattern associations.ResultsIn our current study, significant gFCD and GMV differences were observed in some regions of the visual system, sensorimotor cortices, and cerebellum between patients with DCM and healthy controls. In our findings, decreased gFCD was found in areas primarily located at the sensorimotor cortices, while increased gFCD was observed primarily within areas located at the visual system and cerebellum. Decreased GMV was seen in the left thalamus, bilateral supplementary motor area (SMA), and left inferior occipital cortices in patients with DCM, while increased GMV was observed in the cerebellum.ConclusionOur findings suggest that structural and functional alterations independently contributed to the neuropathology of DCM. However, longitudinal studies are still needed to further illustrate the associations between structural deficits and functional alterations underlying the onset of brain abnormalities as DCM develops. |
| first_indexed | 2024-04-13T20:02:37Z |
| format | Article |
| id | doaj.art-efad7e1078c34c93aec74bb5b6a42024 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T20:02:37Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-efad7e1078c34c93aec74bb5b6a420242022-12-22T02:32:10ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-06-011310.3389/fneur.2022.895348895348Brain Structural and Functional Dissociated Patterns in Degenerative Cervical Myelopathy: A Case-Controlled Retrospective Resting-State fMRI StudyYi ZhouJiaqi ShiBackgroundPrevious studies have shown the whole-brain global functional connectivity density (gFCD) and gray matter volume (GMV) alterations in patients with degenerative cervical myelopathy (DCM). However, no study aimed to investigate the associations between the spatial patterns of GMV and gFCD alterations in patients with DCM.MethodsStructural data and resting-state functional MRI data of 35 DCM patients and 35 matched healthy controls were collected to assess their gFCD and GMV and investigate gFCD and GMV alterations in patients with DCM and their spatial pattern associations.ResultsIn our current study, significant gFCD and GMV differences were observed in some regions of the visual system, sensorimotor cortices, and cerebellum between patients with DCM and healthy controls. In our findings, decreased gFCD was found in areas primarily located at the sensorimotor cortices, while increased gFCD was observed primarily within areas located at the visual system and cerebellum. Decreased GMV was seen in the left thalamus, bilateral supplementary motor area (SMA), and left inferior occipital cortices in patients with DCM, while increased GMV was observed in the cerebellum.ConclusionOur findings suggest that structural and functional alterations independently contributed to the neuropathology of DCM. However, longitudinal studies are still needed to further illustrate the associations between structural deficits and functional alterations underlying the onset of brain abnormalities as DCM develops.https://www.frontiersin.org/articles/10.3389/fneur.2022.895348/fullfMRIVBMfunctional connectivity densitydegenerative cervical myelopathygray matter atrophies |
| spellingShingle | Yi Zhou Jiaqi Shi Brain Structural and Functional Dissociated Patterns in Degenerative Cervical Myelopathy: A Case-Controlled Retrospective Resting-State fMRI Study Frontiers in Neurology fMRI VBM functional connectivity density degenerative cervical myelopathy gray matter atrophies |
| title | Brain Structural and Functional Dissociated Patterns in Degenerative Cervical Myelopathy: A Case-Controlled Retrospective Resting-State fMRI Study |
| title_full | Brain Structural and Functional Dissociated Patterns in Degenerative Cervical Myelopathy: A Case-Controlled Retrospective Resting-State fMRI Study |
| title_fullStr | Brain Structural and Functional Dissociated Patterns in Degenerative Cervical Myelopathy: A Case-Controlled Retrospective Resting-State fMRI Study |
| title_full_unstemmed | Brain Structural and Functional Dissociated Patterns in Degenerative Cervical Myelopathy: A Case-Controlled Retrospective Resting-State fMRI Study |
| title_short | Brain Structural and Functional Dissociated Patterns in Degenerative Cervical Myelopathy: A Case-Controlled Retrospective Resting-State fMRI Study |
| title_sort | brain structural and functional dissociated patterns in degenerative cervical myelopathy a case controlled retrospective resting state fmri study |
| topic | fMRI VBM functional connectivity density degenerative cervical myelopathy gray matter atrophies |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.895348/full |
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