The Combination of Iron and Copper Increases Pathogenicity and Induces Proteins Related to the Main Virulence Factors in Clinical Isolates of <i>Cryptococcus neoformans</i> var. <i>grubii</i>

The Combination of Iron and Copper Increases Pathogenicity and Induces Proteins Related to the Main Virulence Factors in Clinical Isolates of <i>Cryptococcus neoformans</i> var. <i>grubii</i>

In fungi, metals are associated with the expression of virulence factors. However, it is unclear whether the uptake of metals affects their pathogenicity. This study aimed to evaluate the effect of iron/copper in modulating pathogenicity and proteomic response in two clinical isolates of <i>C....

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Main Authors: Nórida Vélez, Lucía Monteoliva, Zilpa-Adriana Sánchez-Quitian, Ahinara Amador-García, Rocío García-Rodas, Andrés Ceballos-Garzón, Concha Gil, Patricia Escandón, Óscar Zaragoza, Claudia-Marcela Parra-Giraldo
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Journal of Fungi
Subjects:
<i>Cryptococcus neoformans</i>
metals
iron
copper
pathogenicity
virulence
Online Access:https://www.mdpi.com/2309-608X/8/1/57

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