Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients
Background: Hemodialysis (HD) patients are at increased risk of reactivation of latent tuberculosis infection (LTBI) compared with the general population. QuantiFERON-TB Gold (QFT-G) for LTBI detection is more promising than tuberculin skin test (TST) in HD patients. AIM: In our study, we evaluated...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Annals of Thoracic Medicine |
| Subjects: | |
| Online Access: | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2016;volume=11;issue=2;spage=114;epage=120;aulast=Seyhan |
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| author | Ekrem Cengiz Seyhan Gulsah Gunluoglu Mehmet Zeki Gunluoglu Seda Tural Sinem Sokucu |
| author_facet | Ekrem Cengiz Seyhan Gulsah Gunluoglu Mehmet Zeki Gunluoglu Seda Tural Sinem Sokucu |
| author_sort | Ekrem Cengiz Seyhan |
| collection | DOAJ |
| description | Background: Hemodialysis (HD) patients are at increased risk of reactivation of latent tuberculosis infection (LTBI) compared with the general population. QuantiFERON-TB Gold (QFT-G) for LTBI detection is more promising than tuberculin skin test (TST) in HD patients.
AIM: In our study, we evaluated the value of the TST and QFT-G In-Tube (QFG-IT) test in the development of active tuberculosis (TB), in the HD patients, and in healthy controls.
Methods: The study enrolled 95 HD patients and ninety age-matched, healthy controls. The TST and QFG-IT were performed. All the subjects were followed up 5 years for active TB disease.
Results: Compared to the healthy controls, a high prevalence of LTBI was found in the HD patients by QFG-IT (41% vs. 25%). However, no significant difference was detected by TST (32% vs. 31%). Four HD patients and one healthy control progressed to active TB disease within the 5-year follow-up. For active TB discovered subjects, QFG-IT was positive in all, but TST was positive in two (one patient and one healthy control). In HD patients; sensitivity, specificity, positive and negative predictive values of QFG-IT, and TST for active TB was 100% and 25%, 62% and 67%, 10%, and 3%, and 100% and 95%, respectively. Receiver operating curve analysis revealed that the results are significantly different (P = 0.04).
Conclusion: QFG-IT test is a more useful diagnostic method than TST for detecting those who will progress to active TB in HD patients. |
| first_indexed | 2024-12-17T06:53:43Z |
| format | Article |
| id | doaj.art-efb0a7bd5b7e4407a25d7014063bae79 |
| institution | Directory Open Access Journal |
| issn | 1817-1737 1998-3557 |
| language | English |
| last_indexed | 2024-12-17T06:53:43Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Thoracic Medicine |
| spelling | doaj.art-efb0a7bd5b7e4407a25d7014063bae792022-12-21T21:59:30ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572016-01-0111211412010.4103/1817-1737.180023Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patientsEkrem Cengiz SeyhanGulsah GunluogluMehmet Zeki GunluogluSeda TuralSinem SokucuBackground: Hemodialysis (HD) patients are at increased risk of reactivation of latent tuberculosis infection (LTBI) compared with the general population. QuantiFERON-TB Gold (QFT-G) for LTBI detection is more promising than tuberculin skin test (TST) in HD patients. AIM: In our study, we evaluated the value of the TST and QFT-G In-Tube (QFG-IT) test in the development of active tuberculosis (TB), in the HD patients, and in healthy controls. Methods: The study enrolled 95 HD patients and ninety age-matched, healthy controls. The TST and QFG-IT were performed. All the subjects were followed up 5 years for active TB disease. Results: Compared to the healthy controls, a high prevalence of LTBI was found in the HD patients by QFG-IT (41% vs. 25%). However, no significant difference was detected by TST (32% vs. 31%). Four HD patients and one healthy control progressed to active TB disease within the 5-year follow-up. For active TB discovered subjects, QFG-IT was positive in all, but TST was positive in two (one patient and one healthy control). In HD patients; sensitivity, specificity, positive and negative predictive values of QFG-IT, and TST for active TB was 100% and 25%, 62% and 67%, 10%, and 3%, and 100% and 95%, respectively. Receiver operating curve analysis revealed that the results are significantly different (P = 0.04). Conclusion: QFG-IT test is a more useful diagnostic method than TST for detecting those who will progress to active TB in HD patients.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2016;volume=11;issue=2;spage=114;epage=120;aulast=SeyhanActive tuberculosishealthy controlshemodialysis patientsQuantiFERON-tuberculosis Gold In-Tubetuberculin skin test |
| spellingShingle | Ekrem Cengiz Seyhan Gulsah Gunluoglu Mehmet Zeki Gunluoglu Seda Tural Sinem Sokucu Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients Annals of Thoracic Medicine Active tuberculosis healthy controls hemodialysis patients QuantiFERON-tuberculosis Gold In-Tube tuberculin skin test |
| title | Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients |
| title_full | Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients |
| title_fullStr | Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients |
| title_full_unstemmed | Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients |
| title_short | Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients |
| title_sort | predictive value of the tuberculin skin test and quantiferon tuberculosis gold in tube test for development of active tuberculosis in hemodialysis patients |
| topic | Active tuberculosis healthy controls hemodialysis patients QuantiFERON-tuberculosis Gold In-Tube tuberculin skin test |
| url | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2016;volume=11;issue=2;spage=114;epage=120;aulast=Seyhan |
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