The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study
Lutein (L), zeaxanthin (Z), and <i>meso</i>-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 8...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/8/767 |
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| author | Marina Green-Gomez Alfonso Prado-Cabrero Rachel Moran Tommy Power Laura G. Gómez-Mascaraque Jim Stack John M. Nolan |
| author_facet | Marina Green-Gomez Alfonso Prado-Cabrero Rachel Moran Tommy Power Laura G. Gómez-Mascaraque Jim Stack John M. Nolan |
| author_sort | Marina Green-Gomez |
| collection | DOAJ |
| description | Lutein (L), zeaxanthin (Z), and <i>meso</i>-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (<i>p</i> < 0.001 to <i>p</i> = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (<i>p</i> = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561). |
| first_indexed | 2024-03-10T17:16:45Z |
| format | Article |
| id | doaj.art-efb41dcdef6a44cb9913e2e599fa7669 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T17:16:45Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-efb41dcdef6a44cb9913e2e599fa76692023-11-20T10:30:10ZengMDPI AGAntioxidants2076-39212020-08-019876710.3390/antiox9080767The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled StudyMarina Green-Gomez0Alfonso Prado-Cabrero1Rachel Moran2Tommy Power3Laura G. Gómez-Mascaraque4Jim Stack5John M. Nolan6Nutrition Research Centre Ireland, School of Health Sciences, Carriganore House, Waterford Institute of Technology West Campus, X91 X236 Waterford, IrelandNutrition Research Centre Ireland, School of Health Sciences, Carriganore House, Waterford Institute of Technology West Campus, X91 X236 Waterford, IrelandNutrition Research Centre Ireland, School of Health Sciences, Carriganore House, Waterford Institute of Technology West Campus, X91 X236 Waterford, IrelandNutrition Research Centre Ireland, School of Health Sciences, Carriganore House, Waterford Institute of Technology West Campus, X91 X236 Waterford, IrelandTeagasc Food Research Centre, Moorepark, Fermoy, P61 C996 Co. Cork, IrelandNutrition Research Centre Ireland, School of Health Sciences, Carriganore House, Waterford Institute of Technology West Campus, X91 X236 Waterford, IrelandNutrition Research Centre Ireland, School of Health Sciences, Carriganore House, Waterford Institute of Technology West Campus, X91 X236 Waterford, IrelandLutein (L), zeaxanthin (Z), and <i>meso</i>-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (<i>p</i> < 0.001 to <i>p</i> = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (<i>p</i> = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561).https://www.mdpi.com/2076-3921/9/8/767<i>meso</i>-zeaxanthinzeaxanthinluteincarotenoid diacetatesbioavailabilitymicromicelles |
| spellingShingle | Marina Green-Gomez Alfonso Prado-Cabrero Rachel Moran Tommy Power Laura G. Gómez-Mascaraque Jim Stack John M. Nolan The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study Antioxidants <i>meso</i>-zeaxanthin zeaxanthin lutein carotenoid diacetates bioavailability micromicelles |
| title | The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study |
| title_full | The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study |
| title_fullStr | The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study |
| title_full_unstemmed | The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study |
| title_short | The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study |
| title_sort | impact of formulation on lutein zeaxanthin and i meso i zeaxanthin bioavailability a randomised double blind placebo controlled study |
| topic | <i>meso</i>-zeaxanthin zeaxanthin lutein carotenoid diacetates bioavailability micromicelles |
| url | https://www.mdpi.com/2076-3921/9/8/767 |
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