Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus
The human respiratory syncytial virus (hRSV) is the main etiologic agent of severe lower respiratory tract infections that affect young children throughout the world, associated with significant morbidity and mortality, becoming a serious public health problem globally. Up to date, no licensed vacci...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.00873/full |
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| author | María José Altamirano-Lagos Fabián E. Díaz Miguel Andrés Mansilla Daniela Rivera-Pérez Daniel Soto Jodi L. McGill Abel E. Vasquez Abel E. Vasquez Alexis M. Kalergis Alexis M. Kalergis |
| author_facet | María José Altamirano-Lagos Fabián E. Díaz Miguel Andrés Mansilla Daniela Rivera-Pérez Daniel Soto Jodi L. McGill Abel E. Vasquez Abel E. Vasquez Alexis M. Kalergis Alexis M. Kalergis |
| author_sort | María José Altamirano-Lagos |
| collection | DOAJ |
| description | The human respiratory syncytial virus (hRSV) is the main etiologic agent of severe lower respiratory tract infections that affect young children throughout the world, associated with significant morbidity and mortality, becoming a serious public health problem globally. Up to date, no licensed vaccines are available to prevent severe hRSV-induced disease, and the generation of safe-effective vaccines has been a challenging task, requiring constant biomedical research aimed to overcome this ailment. Among the difficulties presented by the study of this pathogen, it arises the fact that there is no single animal model that resembles all aspects of the human pathology, which is due to the specificity that this pathogen has for the human host. Thus, for the study of hRSV, different animal models might be employed, depending on the goal of the study. Of all the existing models, the murine model has been the most frequent model of choice for biomedical studies worldwide and has been of great importance at contributing to the development and understanding of vaccines and therapies against hRSV. The most notable use of the murine model is that it is very useful as a first approach in the development of vaccines or therapies such as monoclonal antibodies, suggesting in this way the direction that research could have in other preclinical models that have higher maintenance costs and more complex requirements in its management. However, several additional different models for studying hRSV, such as other rodents, mustelids, ruminants, and non-human primates, have been explored, offering advantages over the murine model. In this review, we discuss the various applications of animal models to the study of hRSV-induced disease and the advantages and disadvantages of each model, highlighting the potential of each model to elucidate different features of the pathology caused by the hRSV infection. |
| first_indexed | 2024-12-14T20:51:22Z |
| format | Article |
| id | doaj.art-efb484f2808a4c5988b81ffe676e612a |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-14T20:51:22Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-efb484f2808a4c5988b81ffe676e612a2022-12-21T22:47:49ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-05-011010.3389/fmicb.2019.00873426088Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial VirusMaría José Altamirano-Lagos0Fabián E. Díaz1Miguel Andrés Mansilla2Daniela Rivera-Pérez3Daniel Soto4Jodi L. McGill5Abel E. Vasquez6Abel E. Vasquez7Alexis M. Kalergis8Alexis M. Kalergis9Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, ChileSección Biotecnología, Instituto de Salud Pública de Chile, Santiago, ChileDepartment of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, United StatesSección Biotecnología, Instituto de Salud Pública de Chile, Santiago, ChileFacultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago, ChileDepartamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileThe human respiratory syncytial virus (hRSV) is the main etiologic agent of severe lower respiratory tract infections that affect young children throughout the world, associated with significant morbidity and mortality, becoming a serious public health problem globally. Up to date, no licensed vaccines are available to prevent severe hRSV-induced disease, and the generation of safe-effective vaccines has been a challenging task, requiring constant biomedical research aimed to overcome this ailment. Among the difficulties presented by the study of this pathogen, it arises the fact that there is no single animal model that resembles all aspects of the human pathology, which is due to the specificity that this pathogen has for the human host. Thus, for the study of hRSV, different animal models might be employed, depending on the goal of the study. Of all the existing models, the murine model has been the most frequent model of choice for biomedical studies worldwide and has been of great importance at contributing to the development and understanding of vaccines and therapies against hRSV. The most notable use of the murine model is that it is very useful as a first approach in the development of vaccines or therapies such as monoclonal antibodies, suggesting in this way the direction that research could have in other preclinical models that have higher maintenance costs and more complex requirements in its management. However, several additional different models for studying hRSV, such as other rodents, mustelids, ruminants, and non-human primates, have been explored, offering advantages over the murine model. In this review, we discuss the various applications of animal models to the study of hRSV-induced disease and the advantages and disadvantages of each model, highlighting the potential of each model to elucidate different features of the pathology caused by the hRSV infection.https://www.frontiersin.org/article/10.3389/fmicb.2019.00873/fullhuman respiratory syncytial virusbovine respiratory syncytial viruslower respiratory tract infectionsrodent modelnon-human primate model |
| spellingShingle | María José Altamirano-Lagos Fabián E. Díaz Miguel Andrés Mansilla Daniela Rivera-Pérez Daniel Soto Jodi L. McGill Abel E. Vasquez Abel E. Vasquez Alexis M. Kalergis Alexis M. Kalergis Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus Frontiers in Microbiology human respiratory syncytial virus bovine respiratory syncytial virus lower respiratory tract infections rodent model non-human primate model |
| title | Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus |
| title_full | Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus |
| title_fullStr | Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus |
| title_full_unstemmed | Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus |
| title_short | Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus |
| title_sort | current animal models for understanding the pathology caused by the respiratory syncytial virus |
| topic | human respiratory syncytial virus bovine respiratory syncytial virus lower respiratory tract infections rodent model non-human primate model |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.00873/full |
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