<i>HOXA</i> Amplification Defines a Genetically Distinct Subset of Angiosarcomas
Angiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48 angiosarcomas and noticed recurrent amplifications of <i>HOXA</i>-cluster genes in 33% of patients. <i>HOXA</i> genes are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/8/1124 |
| _version_ | 1797439243838029824 |
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| author | Hongbo M. Xie Kathrin M. Bernt |
| author_facet | Hongbo M. Xie Kathrin M. Bernt |
| author_sort | Hongbo M. Xie |
| collection | DOAJ |
| description | Angiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48 angiosarcomas and noticed recurrent amplifications of <i>HOXA</i>-cluster genes in 33% of patients. <i>HOXA</i> genes are master regulators of embryonic vascular development and adult neovascularization, which provides a molecular rationale to suspect that amplified <i>HOXA</i> genes act as oncogenes in angiosarcoma. <i>HOXA</i> amplifications typically affected multiple pro-angiogenic <i>HOXA</i> genes and co-occurred with amplifications of <i>CD36</i> and <i>KDR,</i> whereas the overall mutation rate in these tumors was relatively low. <i>HOXA</i> amplifications were found most commonly in angiosarcomas located in the breast and were rare in angiosarcomas arising in sun-exposed areas on the head, neck, face and scalp. Our data suggest that <i>HOXA</i>-amplified angiosarcoma is a distinct molecular subgroup. Efforts to develop therapies targeting oncogenic <i>HOX</i> gene expression in AML and other sarcomas may have relevance for <i>HOXA</i>-amplified angiosarcoma. |
| first_indexed | 2024-03-09T11:49:57Z |
| format | Article |
| id | doaj.art-efb4fb125fff41fe9e4c433ddc2416e2 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T11:49:57Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-efb4fb125fff41fe9e4c433ddc2416e22023-11-30T23:16:28ZengMDPI AGBiomolecules2218-273X2022-08-01128112410.3390/biom12081124<i>HOXA</i> Amplification Defines a Genetically Distinct Subset of AngiosarcomasHongbo M. Xie0Kathrin M. Bernt1Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, 3501 Civic Center Boulevard, CTRB 3064, Philadelphia, PA 19104, USADivision of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, 3501 Civic Center Boulevard, CTRB 3064, Philadelphia, PA 19104, USAAngiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48 angiosarcomas and noticed recurrent amplifications of <i>HOXA</i>-cluster genes in 33% of patients. <i>HOXA</i> genes are master regulators of embryonic vascular development and adult neovascularization, which provides a molecular rationale to suspect that amplified <i>HOXA</i> genes act as oncogenes in angiosarcoma. <i>HOXA</i> amplifications typically affected multiple pro-angiogenic <i>HOXA</i> genes and co-occurred with amplifications of <i>CD36</i> and <i>KDR,</i> whereas the overall mutation rate in these tumors was relatively low. <i>HOXA</i> amplifications were found most commonly in angiosarcomas located in the breast and were rare in angiosarcomas arising in sun-exposed areas on the head, neck, face and scalp. Our data suggest that <i>HOXA</i>-amplified angiosarcoma is a distinct molecular subgroup. Efforts to develop therapies targeting oncogenic <i>HOX</i> gene expression in AML and other sarcomas may have relevance for <i>HOXA</i>-amplified angiosarcoma.https://www.mdpi.com/2218-273X/12/8/1124<i>HOXA</i>homeoboxangiosarcomagenomic |
| spellingShingle | Hongbo M. Xie Kathrin M. Bernt <i>HOXA</i> Amplification Defines a Genetically Distinct Subset of Angiosarcomas Biomolecules <i>HOXA</i> homeobox angiosarcoma genomic |
| title | <i>HOXA</i> Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
| title_full | <i>HOXA</i> Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
| title_fullStr | <i>HOXA</i> Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
| title_full_unstemmed | <i>HOXA</i> Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
| title_short | <i>HOXA</i> Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
| title_sort | i hoxa i amplification defines a genetically distinct subset of angiosarcomas |
| topic | <i>HOXA</i> homeobox angiosarcoma genomic |
| url | https://www.mdpi.com/2218-273X/12/8/1124 |
| work_keys_str_mv | AT hongbomxie ihoxaiamplificationdefinesageneticallydistinctsubsetofangiosarcomas AT kathrinmbernt ihoxaiamplificationdefinesageneticallydistinctsubsetofangiosarcomas |