Risk of decreased ovarian reserve in women with HPV infection and cervical lesions
Abstract Background Human papillomavirus (HPV) infection has been considered an important involved factor for infertility. Since one of the causes of decreased ovarian reserve is oophoritis due to viral infections, this study aimed to evaluated the association between HPV infection and ovarian reser...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.1343 |
| _version_ | 1797770642819383296 |
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| author | Fereshteh Fakor Nasrin G. Gashti Amirhossein H. Fallah Roya Kabodmehri Zahra Rafiei Sorouri Aida Hasanzadi Zahra Pourhabibi |
| author_facet | Fereshteh Fakor Nasrin G. Gashti Amirhossein H. Fallah Roya Kabodmehri Zahra Rafiei Sorouri Aida Hasanzadi Zahra Pourhabibi |
| author_sort | Fereshteh Fakor |
| collection | DOAJ |
| description | Abstract Background Human papillomavirus (HPV) infection has been considered an important involved factor for infertility. Since one of the causes of decreased ovarian reserve is oophoritis due to viral infections, this study aimed to evaluated the association between HPV infection and ovarian reserve. Methods This case‐control study was performed on 219 women aged 25–35 years who were referred to the gynecologic oncology clinic during 2019–2020. The positive or negative HPV infection was confirmed by cervical biopsy and polymerase chain reaction (PCR) test. Cervical lesions or abnormalities in the cervix were assessed by colposcopy and histopathological analysis. Serum anti‐Mullerian hormone (AMH) levels were measured for all participants to assess ovarian reserve. Results The results of this study showed that in patients who were HPV positive, decreased ovarian reserve was more common than in the HPV negative group (p = 0.0001). Also, there was a significant difference between Cervical intraepithelial neoplasia (CIN) I and CIN III sub‐groups in AMH level (p = 0.0001). Conclusions Traces of HPV have been observed in various aspects of infertility, but no study has been performed on its association with ovarian reserve. According to the results of this study, decreased ovarian reserve was more common in patients who were HPV positive. |
| first_indexed | 2024-03-12T21:26:10Z |
| format | Article |
| id | doaj.art-efb80cff229a4bf4906f43f96b46167d |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-12T21:26:10Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-efb80cff229a4bf4906f43f96b46167d2023-07-28T08:52:33ZengWileyHealth Science Reports2398-88352023-07-0167n/an/a10.1002/hsr2.1343Risk of decreased ovarian reserve in women with HPV infection and cervical lesionsFereshteh Fakor0Nasrin G. Gashti1Amirhossein H. Fallah2Roya Kabodmehri3Zahra Rafiei Sorouri4Aida Hasanzadi5Zahra Pourhabibi6Department of Obstetrics & Gynecology, Reproductive Health Research Center, Al‐zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht IranDepartment of Obstetrics & Gynecology, Reproductive Health Research Center, Al‐zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht IranGuilan University of Medical Sciences Rasht IranDepartment of Obstetrics & Gynecology, Reproductive Health Research Center, Al‐zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht IranDepartment of Gynecology, Reproductive Health Research Center, School of Medicine, Al‐zahra Hospital Guilan University of Medical Sciences Rasht IranDepartment of Gynecology, Reproductive Health Research Center, School of Medicine, Al‐zahra Hospital Guilan University of Medical Sciences Rasht IranVice‐Chancellorship of Research and Technology Guilan University of Medical Science Rasht IranAbstract Background Human papillomavirus (HPV) infection has been considered an important involved factor for infertility. Since one of the causes of decreased ovarian reserve is oophoritis due to viral infections, this study aimed to evaluated the association between HPV infection and ovarian reserve. Methods This case‐control study was performed on 219 women aged 25–35 years who were referred to the gynecologic oncology clinic during 2019–2020. The positive or negative HPV infection was confirmed by cervical biopsy and polymerase chain reaction (PCR) test. Cervical lesions or abnormalities in the cervix were assessed by colposcopy and histopathological analysis. Serum anti‐Mullerian hormone (AMH) levels were measured for all participants to assess ovarian reserve. Results The results of this study showed that in patients who were HPV positive, decreased ovarian reserve was more common than in the HPV negative group (p = 0.0001). Also, there was a significant difference between Cervical intraepithelial neoplasia (CIN) I and CIN III sub‐groups in AMH level (p = 0.0001). Conclusions Traces of HPV have been observed in various aspects of infertility, but no study has been performed on its association with ovarian reserve. According to the results of this study, decreased ovarian reserve was more common in patients who were HPV positive.https://doi.org/10.1002/hsr2.1343AMHcervical lesionsdecreased ovarian reserveHPV infectioninfertility |
| spellingShingle | Fereshteh Fakor Nasrin G. Gashti Amirhossein H. Fallah Roya Kabodmehri Zahra Rafiei Sorouri Aida Hasanzadi Zahra Pourhabibi Risk of decreased ovarian reserve in women with HPV infection and cervical lesions Health Science Reports AMH cervical lesions decreased ovarian reserve HPV infection infertility |
| title | Risk of decreased ovarian reserve in women with HPV infection and cervical lesions |
| title_full | Risk of decreased ovarian reserve in women with HPV infection and cervical lesions |
| title_fullStr | Risk of decreased ovarian reserve in women with HPV infection and cervical lesions |
| title_full_unstemmed | Risk of decreased ovarian reserve in women with HPV infection and cervical lesions |
| title_short | Risk of decreased ovarian reserve in women with HPV infection and cervical lesions |
| title_sort | risk of decreased ovarian reserve in women with hpv infection and cervical lesions |
| topic | AMH cervical lesions decreased ovarian reserve HPV infection infertility |
| url | https://doi.org/10.1002/hsr2.1343 |
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