Relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease
Objective To analyze relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease (PD). Methods A total of 130 elderly patients with PD admitted to The Affiliated Brain Hospital of Nanjing Medical University from January 2020 to December 20...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tianjin Huanhu Hospital
2024-03-01
|
| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2837 |
| _version_ | 1797232560045031424 |
|---|---|
| author | JI Li YANG Ning LIU Wei‑guo JI Li |
| author_facet | JI Li YANG Ning LIU Wei‑guo JI Li |
| author_sort | JI Li |
| collection | DOAJ |
| description | Objective To analyze relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease (PD). Methods A total of 130 elderly patients with PD admitted to The Affiliated Brain Hospital of Nanjing Medical University from January 2020 to December 2022 were included. Hoehn‑Yahr staging was used to evaluate stage of the disease, Unified Parkinson's Disease Rating Scale Ⅲ (UPDRS Ⅲ) was used to evaluate the severity of motor disorders, Scales for Outcomes in Parkinson's Disease ‑ Autonomic (SCOPA ‑ AUT) was used to evaluate autonomic nervous function, Mini‑Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to evaluate cognitive function, Non‑Μotor Symptoms Scale (NMSS) was used to evaluate the severity of nonmotor symptoms. Results According to whether the patients were accompanied by Alzheimer's disease (AD), they were divided into a group with AD (n = 82) and a group without AD (n = 48). The proportion of Hoehn‑Yahr staging 3 to 5 (χ2 = 5.689, P = 0.017), UPDRSⅢ score (t = 21.490, P = 0.000), SCOPA‑AUT score (t = 21.330, P = 0.000), dysregulation of body temperature (χ2 = 8.512, P = 0.004), urinary dysfunction (χ2 = 17.270, P = 0.000), gastrointestinal dysfunction (χ2 = 24.471, P = 0.000), dysregulation of pupil (χ2 = 5.299, P = 0.021), cardiovascular dysfunction (χ2 = 15.355, P = 0.000) and NMSS score (t = 32.309, P = 0.000) in the group with AD were higher than those in the group without AD, the MMSE (t = 4.730, P = 0.000) and MoCA (t = 6.840, P = 0.000) total scores and subtype scores (P = 0.000, for all) in the group with AD were lower than those in the group without AD. Correlation analysis showed that the SCOPA‑AUT score of PD patients with AD was negatively correlated with MMSE and MoCA total scores and subtype scores (P = 0.000, for all). Conclusions The autonomic dysfunction of elderly PD patients with AD is more serious, and the autonomic nervous function is closely related to cognitive function. |
| first_indexed | 2024-04-24T16:02:13Z |
| format | Article |
| id | doaj.art-efb83b51be1847c49f6e3bd035142b73 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-04-24T16:02:13Z |
| publishDate | 2024-03-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-efb83b51be1847c49f6e3bd035142b732024-04-01T07:14:30ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312024-03-0124317117610.3969/j.issn.1672‑6731.2024.03.0102791Relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's diseaseJI Li0YANG Ning1LIU Wei‑guo2JI Li3Department of Critical Care Medicine,The Affiliated Brain Hospital of Nanjing Medical University; Nanjing Brain Hospital, Nanjing 210029, Jiangsu, ChinaDepartment of Traditional Chinese Medicine,The Affiliated Brain Hospital of Nanjing Medical University; Nanjing Brain Hospital, Nanjing 210029, Jiangsu, ChinaDepartment of Neurology,The Affiliated Brain Hospital of Nanjing Medical University; Nanjing Brain Hospital, Nanjing 210029, Jiangsu, ChinaDepartment of Critical Care Medicine,The Affiliated Brain Hospital of Nanjing Medical University; Nanjing Brain Hospital, Nanjing 210029, Jiangsu, ChinaObjective To analyze relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease (PD). Methods A total of 130 elderly patients with PD admitted to The Affiliated Brain Hospital of Nanjing Medical University from January 2020 to December 2022 were included. Hoehn‑Yahr staging was used to evaluate stage of the disease, Unified Parkinson's Disease Rating Scale Ⅲ (UPDRS Ⅲ) was used to evaluate the severity of motor disorders, Scales for Outcomes in Parkinson's Disease ‑ Autonomic (SCOPA ‑ AUT) was used to evaluate autonomic nervous function, Mini‑Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to evaluate cognitive function, Non‑Μotor Symptoms Scale (NMSS) was used to evaluate the severity of nonmotor symptoms. Results According to whether the patients were accompanied by Alzheimer's disease (AD), they were divided into a group with AD (n = 82) and a group without AD (n = 48). The proportion of Hoehn‑Yahr staging 3 to 5 (χ2 = 5.689, P = 0.017), UPDRSⅢ score (t = 21.490, P = 0.000), SCOPA‑AUT score (t = 21.330, P = 0.000), dysregulation of body temperature (χ2 = 8.512, P = 0.004), urinary dysfunction (χ2 = 17.270, P = 0.000), gastrointestinal dysfunction (χ2 = 24.471, P = 0.000), dysregulation of pupil (χ2 = 5.299, P = 0.021), cardiovascular dysfunction (χ2 = 15.355, P = 0.000) and NMSS score (t = 32.309, P = 0.000) in the group with AD were higher than those in the group without AD, the MMSE (t = 4.730, P = 0.000) and MoCA (t = 6.840, P = 0.000) total scores and subtype scores (P = 0.000, for all) in the group with AD were lower than those in the group without AD. Correlation analysis showed that the SCOPA‑AUT score of PD patients with AD was negatively correlated with MMSE and MoCA total scores and subtype scores (P = 0.000, for all). Conclusions The autonomic dysfunction of elderly PD patients with AD is more serious, and the autonomic nervous function is closely related to cognitive function.http://www.cjcnn.org/index.php/cjcnn/article/view/2837parkinson diseasealzheimer diseaseautonomic nervous systemcognition disorders |
| spellingShingle | JI Li YANG Ning LIU Wei‑guo JI Li Relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease Chinese Journal of Contemporary Neurology and Neurosurgery parkinson disease alzheimer disease autonomic nervous system cognition disorders |
| title | Relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease |
| title_full | Relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease |
| title_fullStr | Relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease |
| title_full_unstemmed | Relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease |
| title_short | Relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease |
| title_sort | relationship between autonomic nervous function and cognitive function in elderly patients with parkinson s disease |
| topic | parkinson disease alzheimer disease autonomic nervous system cognition disorders |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2837 |
| work_keys_str_mv | AT jili relationshipbetweenautonomicnervousfunctionandcognitivefunctioninelderlypatientswithparkinsonsdisease AT yangning relationshipbetweenautonomicnervousfunctionandcognitivefunctioninelderlypatientswithparkinsonsdisease AT liuweiguo relationshipbetweenautonomicnervousfunctionandcognitivefunctioninelderlypatientswithparkinsonsdisease AT jili relationshipbetweenautonomicnervousfunctionandcognitivefunctioninelderlypatientswithparkinsonsdisease |