Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesions
IntroductionProstate cancer is one of the most common malignant tumors in Chinese men, which is rich in iron metabolic activity and is closely related to all stages of prostate cancer progression. Since the current diagnostic methods are insufficient, we aimed to evaluate the value of quantitative T...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1185057/full |
| _version_ | 1797824138611523584 |
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| author | Wenhao D Guangzheng L Zhen T Xuedong W Yonggang L Xuefeng Z Weijie Z Gang L Yuhua H |
| author_facet | Wenhao D Guangzheng L Zhen T Xuedong W Yonggang L Xuefeng Z Weijie Z Gang L Yuhua H |
| author_sort | Wenhao D |
| collection | DOAJ |
| description | IntroductionProstate cancer is one of the most common malignant tumors in Chinese men, which is rich in iron metabolic activity and is closely related to all stages of prostate cancer progression. Since the current diagnostic methods are insufficient, we aimed to evaluate the value of quantitative T2 star values from the T2* mapping sequences in multiparametric magnetic resonance imaging (mpMRI) in the diagnosis and grading of PI-RADS 3 prostate cancer (PCa).MethodsWe prospectively enrolled patients with PCa or benign prostatic hyperplasia (BPH) admitted to our hospital from January 2021 to November 2022. Imaging indicators, including the T2* value and apparent diffusion coefficient (ADC) value, were collected, and enzyme-linked immunosorbent assays (ELISAs) were used to measure the levels of proteins involved in iron metabolism in the patients. ROC curves were drawn to explore whether the T2* value could be used for the diagnosis and grading of PCa.ResultsWe found that three iron metabolism indexes, ferritin, hepcidin, and the ferric ion (Fe), and the T2* value were significantly different between the PCa group and BPH group and between the low International Society of Urology Pathology (ISUP) group (ISUP ≤ 2) and the high ISUP group (ISUP>2). Additionally, there was a significant correlation between the levels of these three indicators and the T2* value. Further ROC analysis showed that the levels of iron metabolism-related indexes and T2* values performed well in diagnosing and grading PCa.DiscussionThe T2* value has good value in detecting and predicting the grade of prostate cancer and can reflect the iron metabolism of the tumor, which could provide a foundation for the diagnosis and grading of PCa in the future. |
| first_indexed | 2024-03-13T10:34:32Z |
| format | Article |
| id | doaj.art-efbac44f03514efda618f6cadc29b11f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T10:34:32Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-efbac44f03514efda618f6cadc29b11f2023-05-18T07:37:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-05-011310.3389/fonc.2023.11850571185057Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesionsWenhao D0Guangzheng L1Zhen T2Xuedong W3Yonggang L4Xuefeng Z5Weijie Z6Gang L7Yuhua H8Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaIntroductionProstate cancer is one of the most common malignant tumors in Chinese men, which is rich in iron metabolic activity and is closely related to all stages of prostate cancer progression. Since the current diagnostic methods are insufficient, we aimed to evaluate the value of quantitative T2 star values from the T2* mapping sequences in multiparametric magnetic resonance imaging (mpMRI) in the diagnosis and grading of PI-RADS 3 prostate cancer (PCa).MethodsWe prospectively enrolled patients with PCa or benign prostatic hyperplasia (BPH) admitted to our hospital from January 2021 to November 2022. Imaging indicators, including the T2* value and apparent diffusion coefficient (ADC) value, were collected, and enzyme-linked immunosorbent assays (ELISAs) were used to measure the levels of proteins involved in iron metabolism in the patients. ROC curves were drawn to explore whether the T2* value could be used for the diagnosis and grading of PCa.ResultsWe found that three iron metabolism indexes, ferritin, hepcidin, and the ferric ion (Fe), and the T2* value were significantly different between the PCa group and BPH group and between the low International Society of Urology Pathology (ISUP) group (ISUP ≤ 2) and the high ISUP group (ISUP>2). Additionally, there was a significant correlation between the levels of these three indicators and the T2* value. Further ROC analysis showed that the levels of iron metabolism-related indexes and T2* values performed well in diagnosing and grading PCa.DiscussionThe T2* value has good value in detecting and predicting the grade of prostate cancer and can reflect the iron metabolism of the tumor, which could provide a foundation for the diagnosis and grading of PCa in the future.https://www.frontiersin.org/articles/10.3389/fonc.2023.1185057/fullprostate cancerPI-RADSiron mentalismmultiparametric magnetic resonance imagingdiagnosis |
| spellingShingle | Wenhao D Guangzheng L Zhen T Xuedong W Yonggang L Xuefeng Z Weijie Z Gang L Yuhua H Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesions Frontiers in Oncology prostate cancer PI-RADS iron mentalism multiparametric magnetic resonance imaging diagnosis |
| title | Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesions |
| title_full | Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesions |
| title_fullStr | Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesions |
| title_full_unstemmed | Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesions |
| title_short | Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesions |
| title_sort | study of iron metabolism based on t2 mapping sequences in pi rads 3 prostate lesions |
| topic | prostate cancer PI-RADS iron mentalism multiparametric magnetic resonance imaging diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1185057/full |
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