The changing understanding of ageing. Part 1: Evaluating ageing theories and studies
This is the first of three discussions on emerging views of ageing, its derivation, and ageing-related diseases. To offer a context for the series, this first report briefly reviews several major early and recent theoretical debates. Arguments for and against several well-known ageing theories are p...
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| Format: | Article |
| Language: | English |
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Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
2011-09-01
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| Series: | Veterinaria Italiana |
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| Online Access: | http://www.izs.it/vet_italiana/2011/47_3/229.pdf |
| _version_ | 1818548965500518400 |
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| author | Dennis F. Lawler |
| author_facet | Dennis F. Lawler |
| author_sort | Dennis F. Lawler |
| collection | DOAJ |
| description | This is the first of three discussions on emerging views of ageing, its derivation, and ageing-related diseases. To offer a context for the series, this first report briefly reviews several major early and recent theoretical debates. Arguments for and against several well-known ageing theories are presented for their veterinary relevance, including mutation, pleiotropy, reproduction-longevity trade-offs, oxygen metabolism and ageing as a genomically programmed product of natural selection. Additionally, the author presents commonly encountered problems when reading to interpret laboratory and population studies of ageing, offering busy clinicians a perspective on evaluating complex papers that analyse ageing-related data. Included among these problems are categorising intrinsic and extrinsic diseases, contrasts between laboratory-based and population-based observations, over-generalising research outcomes, short-term and long-term studies, and theoretical treatises. Central ideas of these discussions include why post-reproductive life span is relatively common among animals, the nature of age-related diseases relative to stochastic or programmed origins and the disease-related implications. |
| first_indexed | 2024-12-12T08:27:17Z |
| format | Article |
| id | doaj.art-efbb878975a0460eadf2cfedbd9de798 |
| institution | Directory Open Access Journal |
| issn | 0505-401X 1828-1427 |
| language | English |
| last_indexed | 2024-12-12T08:27:17Z |
| publishDate | 2011-09-01 |
| publisher | Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale |
| record_format | Article |
| series | Veterinaria Italiana |
| spelling | doaj.art-efbb878975a0460eadf2cfedbd9de7982022-12-22T00:31:13ZengIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. CaporaleVeterinaria Italiana0505-401X1828-14272011-09-01473229240The changing understanding of ageing. Part 1: Evaluating ageing theories and studiesDennis F. LawlerThis is the first of three discussions on emerging views of ageing, its derivation, and ageing-related diseases. To offer a context for the series, this first report briefly reviews several major early and recent theoretical debates. Arguments for and against several well-known ageing theories are presented for their veterinary relevance, including mutation, pleiotropy, reproduction-longevity trade-offs, oxygen metabolism and ageing as a genomically programmed product of natural selection. Additionally, the author presents commonly encountered problems when reading to interpret laboratory and population studies of ageing, offering busy clinicians a perspective on evaluating complex papers that analyse ageing-related data. Included among these problems are categorising intrinsic and extrinsic diseases, contrasts between laboratory-based and population-based observations, over-generalising research outcomes, short-term and long-term studies, and theoretical treatises. Central ideas of these discussions include why post-reproductive life span is relatively common among animals, the nature of age-related diseases relative to stochastic or programmed origins and the disease-related implications.http://www.izs.it/vet_italiana/2011/47_3/229.pdfAgeingDiseaseDietEvolutionProgrammed ageingReproduction. |
| spellingShingle | Dennis F. Lawler The changing understanding of ageing. Part 1: Evaluating ageing theories and studies Veterinaria Italiana Ageing Disease Diet Evolution Programmed ageing Reproduction. |
| title | The changing understanding of ageing. Part 1: Evaluating ageing theories and studies |
| title_full | The changing understanding of ageing. Part 1: Evaluating ageing theories and studies |
| title_fullStr | The changing understanding of ageing. Part 1: Evaluating ageing theories and studies |
| title_full_unstemmed | The changing understanding of ageing. Part 1: Evaluating ageing theories and studies |
| title_short | The changing understanding of ageing. Part 1: Evaluating ageing theories and studies |
| title_sort | changing understanding of ageing part 1 evaluating ageing theories and studies |
| topic | Ageing Disease Diet Evolution Programmed ageing Reproduction. |
| url | http://www.izs.it/vet_italiana/2011/47_3/229.pdf |
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