Biomarkers in chronic obstructive pulmonary disease: confusing or useful?
Robert A Stockley Queen Elizabeth Hospital Birmingham, Lung Function and Sleep Department, Birmingham, UK Abstract: The field of biomarker research has almost reached unmanageable proportions in chronic obstructive pulmonary disease (COPD). The developments of new technology platforms have generate...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014-02-01
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| Series: | International Journal of COPD |
| Online Access: | http://www.dovepress.com/biomarkers-in-chronic-obstructive-pulmonary-disease-confusing-or-usefu-a15731 |
| _version_ | 1818807552982384640 |
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| author | Stockley RA |
| author_facet | Stockley RA |
| author_sort | Stockley RA |
| collection | DOAJ |
| description | Robert A Stockley Queen Elizabeth Hospital Birmingham, Lung Function and Sleep Department, Birmingham, UK Abstract: The field of biomarker research has almost reached unmanageable proportions in chronic obstructive pulmonary disease (COPD). The developments of new technology platforms have generated a huge information data base, both cross sectionally and increasingly, longitudinally. The knowledge emerging provides an enormous potential for understanding the disease pathophysiology, for developing markers specific for long-term outcomes, and for developing new therapeutic strategies. However, the excitement must be tempered with an understanding of the limitations of the data collection techniques, and of the variations in disease state, activity, impact, and progression. Nevertheless, the most crucial aspect in interpreting the current literature is the recognition of the relatively superficial characterization of what is a complex group of pathological processes with a common end point of airflow limitation. The current review explores some of these issues together with those areas where real progress appears to have been made, and provides caution on interpretation. Keyword: emphysema, inflammation, secretions, technology platforms |
| first_indexed | 2024-12-18T19:27:29Z |
| format | Article |
| id | doaj.art-efbce727fc4e486eb78464cb694b2c08 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-18T19:27:29Z |
| publishDate | 2014-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-efbce727fc4e486eb78464cb694b2c082022-12-21T20:55:50ZengDove Medical PressInternational Journal of COPD1178-20052014-02-012014default16317715731Biomarkers in chronic obstructive pulmonary disease: confusing or useful?Stockley RARobert A Stockley Queen Elizabeth Hospital Birmingham, Lung Function and Sleep Department, Birmingham, UK Abstract: The field of biomarker research has almost reached unmanageable proportions in chronic obstructive pulmonary disease (COPD). The developments of new technology platforms have generated a huge information data base, both cross sectionally and increasingly, longitudinally. The knowledge emerging provides an enormous potential for understanding the disease pathophysiology, for developing markers specific for long-term outcomes, and for developing new therapeutic strategies. However, the excitement must be tempered with an understanding of the limitations of the data collection techniques, and of the variations in disease state, activity, impact, and progression. Nevertheless, the most crucial aspect in interpreting the current literature is the recognition of the relatively superficial characterization of what is a complex group of pathological processes with a common end point of airflow limitation. The current review explores some of these issues together with those areas where real progress appears to have been made, and provides caution on interpretation. Keyword: emphysema, inflammation, secretions, technology platformshttp://www.dovepress.com/biomarkers-in-chronic-obstructive-pulmonary-disease-confusing-or-usefu-a15731 |
| spellingShingle | Stockley RA Biomarkers in chronic obstructive pulmonary disease: confusing or useful? International Journal of COPD |
| title | Biomarkers in chronic obstructive pulmonary disease: confusing or useful? |
| title_full | Biomarkers in chronic obstructive pulmonary disease: confusing or useful? |
| title_fullStr | Biomarkers in chronic obstructive pulmonary disease: confusing or useful? |
| title_full_unstemmed | Biomarkers in chronic obstructive pulmonary disease: confusing or useful? |
| title_short | Biomarkers in chronic obstructive pulmonary disease: confusing or useful? |
| title_sort | biomarkers in chronic obstructive pulmonary disease confusing or useful |
| url | http://www.dovepress.com/biomarkers-in-chronic-obstructive-pulmonary-disease-confusing-or-usefu-a15731 |
| work_keys_str_mv | AT stockleyra biomarkersinchronicobstructivepulmonarydiseaseconfusingoruseful |