The New Genetic Landscape of Cushing’s Disease: Deubiquitinases in the Spotlight

The New Genetic Landscape of Cushing’s Disease: Deubiquitinases in the Spotlight

Cushing’s disease (CD) is a rare condition caused by adrenocorticotropic hormone (ACTH)-producing adenomas of the pituitary, which lead to hypercortisolism that is associated with high morbidity and mortality. Treatment options in case of persistent or recurrent disease are limited, but ne...

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Bibliographic Details
Main Authors: Silviu Sbiera, Meik Kunz, Isabel Weigand, Timo Deutschbein, Thomas Dandekar, Martin Fassnacht
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
cushing’s disease
pathogenesis
somatic mutations
deubiquitinases
Online Access:https://www.mdpi.com/2072-6694/11/11/1761

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