NMDA receptor antagonist ketamine impairs feature integration in visual perception.
Recurrent interactions between neurons in the visual cortex are crucial for the integration of image elements into coherent objects, such as in figure-ground segregation of textured images. Blocking N-methyl-D-aspartate (NMDA) receptors in monkeys can abolish neural signals related to figure-ground...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3815103?pdf=render |
| _version_ | 1819090478346272768 |
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| author | Julia D I Meuwese Anouk M van Loon H Steven Scholte Philipp B Lirk Nienke C C Vulink Markus W Hollmann Victor A F Lamme |
| author_facet | Julia D I Meuwese Anouk M van Loon H Steven Scholte Philipp B Lirk Nienke C C Vulink Markus W Hollmann Victor A F Lamme |
| author_sort | Julia D I Meuwese |
| collection | DOAJ |
| description | Recurrent interactions between neurons in the visual cortex are crucial for the integration of image elements into coherent objects, such as in figure-ground segregation of textured images. Blocking N-methyl-D-aspartate (NMDA) receptors in monkeys can abolish neural signals related to figure-ground segregation and feature integration. However, it is unknown whether this also affects perceptual integration itself. Therefore, we tested whether ketamine, a non-competitive NMDA receptor antagonist, reduces feature integration in humans. We administered a subanesthetic dose of ketamine to healthy subjects who performed a texture discrimination task in a placebo-controlled double blind within-subject design. We found that ketamine significantly impaired performance on the texture discrimination task compared to the placebo condition, while performance on a control fixation task was much less impaired. This effect is not merely due to task difficulty or a difference in sedation levels. We are the first to show a behavioral effect on feature integration by manipulating the NMDA receptor in humans. |
| first_indexed | 2024-12-21T22:24:28Z |
| format | Article |
| id | doaj.art-efc0228c422347759e5ed0b31d230a62 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T22:24:28Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-efc0228c422347759e5ed0b31d230a622022-12-21T18:48:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7932610.1371/journal.pone.0079326NMDA receptor antagonist ketamine impairs feature integration in visual perception.Julia D I MeuweseAnouk M van LoonH Steven ScholtePhilipp B LirkNienke C C VulinkMarkus W HollmannVictor A F LammeRecurrent interactions between neurons in the visual cortex are crucial for the integration of image elements into coherent objects, such as in figure-ground segregation of textured images. Blocking N-methyl-D-aspartate (NMDA) receptors in monkeys can abolish neural signals related to figure-ground segregation and feature integration. However, it is unknown whether this also affects perceptual integration itself. Therefore, we tested whether ketamine, a non-competitive NMDA receptor antagonist, reduces feature integration in humans. We administered a subanesthetic dose of ketamine to healthy subjects who performed a texture discrimination task in a placebo-controlled double blind within-subject design. We found that ketamine significantly impaired performance on the texture discrimination task compared to the placebo condition, while performance on a control fixation task was much less impaired. This effect is not merely due to task difficulty or a difference in sedation levels. We are the first to show a behavioral effect on feature integration by manipulating the NMDA receptor in humans.http://europepmc.org/articles/PMC3815103?pdf=render |
| spellingShingle | Julia D I Meuwese Anouk M van Loon H Steven Scholte Philipp B Lirk Nienke C C Vulink Markus W Hollmann Victor A F Lamme NMDA receptor antagonist ketamine impairs feature integration in visual perception. PLoS ONE |
| title | NMDA receptor antagonist ketamine impairs feature integration in visual perception. |
| title_full | NMDA receptor antagonist ketamine impairs feature integration in visual perception. |
| title_fullStr | NMDA receptor antagonist ketamine impairs feature integration in visual perception. |
| title_full_unstemmed | NMDA receptor antagonist ketamine impairs feature integration in visual perception. |
| title_short | NMDA receptor antagonist ketamine impairs feature integration in visual perception. |
| title_sort | nmda receptor antagonist ketamine impairs feature integration in visual perception |
| url | http://europepmc.org/articles/PMC3815103?pdf=render |
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