TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

Ten-eleven translocation hydroxylases (TET1-3) oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). In neurons, increased 5hmC levels within gene bodies correlate positively with gene expression. The mechanisms controlling TET activity and 5hmC levels are poorly understood. In particula...

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Bibliographic Details
Main Authors: Arshan Perera, David Eisen, Mirko Wagner, Silvia K. Laube, Andrea F. Künzel, Susanne Koch, Jessica Steinbacher, Elisabeth Schulze, Victoria Splith, Nana Mittermeier, Markus Müller, Martin Biel, Thomas Carell, Stylianos Michalakis
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715002739

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