ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma.

ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma.

Hypoxia-inducible factor (HIF) is an attractive therapeutic target for renal cell carcinoma (RCC) as its high expression due to the loss of von Hippel-Lindau (VHL) promotes RCC progression. Considering this, we hypothesized that ELR510444, a novel orally available small molecule inhibitor of HIF act...

Full description

Bibliographic Details
Main Authors:	Jennifer S Carew, Juan A Esquivel, Claudia M Espitia, Christoph M Schultes, Marcel Mülbaier, Joe D Lewis, Bernd Janssen, Francis J Giles, Steffan T Nawrocki
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3266297?pdf=render

Similar Items

ELR Interview with Daniela Calisi
by: Daniele Giampà Labirintesto
Published: (2015-07-01)

Contribution of the ELRs to the development of advanced in vitro models
by: María Puertas-Bartolomé, et al.
Published: (2024-04-01)

Genome editing abrogates angiogenesis in vivo
by: Huang, Xionggao, et al.
Published: (2017)

Genome editing abrogates angiogenesis in vivo
by: Xionggao Huang, et al.
Published: (2017-07-01)

PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS‐driven ELR+ CXC chemokine expression
by: Yan Zhao, et al.
Published: (2023-01-01)

PPAR-γ Activation Inhibits Angiogenesis by Blocking ELR+CXC Chemokine Production in Non-small Cell Lung Cancer
by: Venkateshwar G. Keshamouni, et al.
Published: (2005-03-01)

ELR+ CXC chemokine expression in benign and malignant colorectal conditions
by: Brittner Brigitte, et al.
Published: (2008-06-01)

Moving beyond hydroxychloroquine: the novel lysosomal autophagy inhibitor ROC-325 shows significant potential in preclinical studies
by: Trace M. Jones, et al.
Published: (2019-11-01)

Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance
by: Jennifer S Carew, et al.
Published: (2008-06-01)

Targeting JAK/STAT Signaling Antagonizes Resistance to Oncolytic Reovirus Therapy Driven by Prior Infection with HTLV-1 in Models of T-Cell Lymphoma
by: Shariful Islam, et al.
Published: (2021-07-01)

Autophagy: New Insights into Its Roles in Cancer Progression and Drug Resistance
by: Steffan T. Nawrocki, et al.
Published: (2020-10-01)

CXC ELR-Positive Chemokines as Diagnostic and Prognostic Markers for Breast Cancer Patients
by: Joanna Motyka, et al.
Published: (2023-06-01)

Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody
by: Jeffrey S. Boyles, et al.
Published: (2020-01-01)

ELR positive CXCL chemokines are highly expressed in an animal model of ulcerative colitis
by: Boshagh MA, et al.
Published: (2019-06-01)

Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer Models
by: Devalingam Mahalingam, et al.
Published: (2019-06-01)

Therapeutic Targeting of Autophagy for Renal Cell Carcinoma Therapy
by: Trace M. Jones, et al.
Published: (2020-05-01)

Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer.
by: Anne-Marie Baird, et al.
Published: (2011-01-01)

Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism
by: Trace M. Jones, et al.
Published: (2022-04-01)

Regulation of angiogenesis by hypoxia: role of the HIF system.
by: Pugh, C, et al.
Published: (2003)

Disruption of Growth Hormone Receptor Signaling Abrogates Hepatocellular Carcinoma Development
by: Haque A, et al.
Published: (2022-08-01)

Targeting of the ELR+CXCL/CXCR1/2 Pathway Is a Relevant Strategy for the Treatment of Paediatric Medulloblastomas
by: Manon Penco-Campillo, et al.
Published: (2022-12-01)

Evaluation of LAI Estimation of Mangrove Communities Using DLR and ELR Algorithms With UAV, Hyperspectral, and SAR Images
by: Bolin Fu, et al.
Published: (2022-07-01)

Targeting NEDDylation as a Novel Approach to Improve the Treatment of Head and Neck Cancer
by: Trace M. Jones, et al.
Published: (2021-06-01)

Microtubule Disruption Without Learning Impairment in the Unicellular Organism, Paramecium: Implications for Information Processing in Microtubules
by: Abolfazl Alipour, et al.
Published: (2022-01-01)

Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines
by: Adalsteinsson, Viktor A., et al.
Published: (2014)

Loss of microtubule-to-actin linkage disrupts cortical development.
by: Richard Robinson
Published: (2011-10-01)

Microtubule disruption changes endothelial cell mechanics and adhesion
by: Andreas Weber, et al.
Published: (2019-10-01)

HIF-isoforms have divergent roles in the angiogenesis of colorectal cancer
by: Thairu, N, et al.
Published: (2012)

Control of endothelial cell polarity and sprouting angiogenesis by non-centrosomal microtubules
by: Maud Martin, et al.
Published: (2018-03-01)

The frequency of cytomegalovirus non-ELR UL146 genotypes in neonates with congenital CMV disease is comparable to strains in the background population
by: Christian Berg, et al.
Published: (2021-04-01)

The Enterococcus faecalis virulence factor ElrA interacts with the human Four-and-a-Half LIM Domains Protein 2
by: Alexandre Jamet, et al.
Published: (2017-07-01)

A Fairy Chemical Suppresses Retinal Angiogenesis as a HIF Inhibitor
by: Deokho Lee, et al.
Published: (2020-10-01)

DEVELOPMENT OF A METHODOLOGY FOR SPECIFIC DISRUPTION OF MICROTUBULES IN DENDRITIC SPINES
by: Elizabeth Holland, et al.
Published: (2023-10-01)

Microtubule cytoskeleton-disrupting activity of MWCNTs: applications in cancer treatment
by: Lorena García Hevia, et al.
Published: (2020-12-01)

Hexavalent Chromium Disrupts Oocyte Development in Rats by Elevating Oxidative Stress, DNA Double-Strand Breaks, Microtubule Disruption, and Aberrant Segregation of Chromosomes
by: Liga Wuri, et al.
Published: (2023-06-01)

Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro
by: Byungdoo Hwang, et al.
Published: (2022-07-01)

Oncolytic Viruses for Multiple Myeloma Therapy
by: Christine M. Calton, et al.
Published: (2018-06-01)

Targeting HIF-1α abrogates PD-L1–mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues
by: Christopher M. Bailey, et al.
Published: (2022-05-01)

The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression
by: Stengel, C, et al.
Published: (2015)

The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression
by: Stengel, C, et al.
Published: (2015)